Click here to switch to the map view.

The map label for this gene is hemZ

Identifier: 16081159

GI number: 16081159

Start: 1057680

End: 1059185

Strand: Direct

Name: hemZ

Synonym: BSU09840

Alternate gene names: 16081159

Gene position: 1057680-1059185 (Clockwise)

Preceding gene: 50812207

Following gene: 255767227

Centisome position: 25.09

GC content: 44.95

Gene sequence:

>1506_bases
TTGCAAATTAAAATAGAAGGCATACATGATGACCGCCTGCATCGGCCTCTGCAAAATATTGCAAATTTGTTTTATGAAGA
GTGCGAGCTTGCGTATGGCGGAGAGGAGCCCGCAGATTTTGTCATTTCTTTAGCGTTGTCACAAACGGATGAGCATGTGA
CGGTTTCTGGAGAAGTGAAGGGTACTGGCATAAAGGAACAGCATACAAAATTCTTTTCTCCAGACATGACTGAAAAAGAA
GCTTTTAAGCAAGTGAAAAACACAATTTCTTATGTGTATCTCAATCTTCTTCAGGCGCATACGGGCATTACGCAGAAGTG
GGGAATCCTCACAGGAATCCGGCCCACAAAGCTGCTTCATAAAAAACTGCAAAGCGGAATGTCCAAGGAGCAAGCGCATG
CTGAGTTGAAAAAAGACTATTTAATTCATGATGAAAAAATCATGCTAATGCAGGAAATTGTTGACCGTCAGCTGGCGGCA
GTGCCGGATTTGTACCGAGTAAAGGATGAAGTCAGCATTTATATCGGCATTCCGTTCTGCCCGACAAAATGCGCGTATTG
CACATTCCCTGCGTACGCTATCCAAGGACAGGCGGGCAGAGTCGGCTCATTCCTATGGGGACTGCATTACGAAATGCAGA
AAATCGGTGAATGGCTGAAGGAGCATGATGTTAAGGTTACAACCATTTACTTTGGCGGCGGGACGCCGACAAGCATTACA
GCGGAGGAGATGGATCTGCTGTATGAAGAAATGGTCCGCTCCTTCCCGGATGTGAAAAACATTCGTGAGATTACGGTGGA
GGCCGGTCGTCCTGACACGATTACAGAAGAAAAACTCGCCGTTTTAAACAAATATGACATTGATCGGATCAGCATCAATC
CGCAATCCTACGAAAACGAAACGCTAAAGGCGATCGGGCGGCACCATACGGTTGAAGAGACCATTGAGAAATATCATCTG
TCACGCCAGCACGGCATGAATAATATTAACATGGACTTGATTATTGGTTTGCCTGGGGAAGGCGTGAAGGAGTTCAGGCA
CAGTCTTTCAGAAACAGAAAAACTGATGCCGGAATCCCTTACCGTTCATACTCTTTCATTTAAACGGGCGTCAGAAATGA
CGAGAAACAAGCATAAGTACAAAGTTGCCGGCAGGGAAGAGGTTTCTCAAATGATGGAAGACGCGGTAGCCTGGACGAAA
GAGCATGGGTACGTGCCTTATTATTTATACCGCCAGAAAAACATTCTTGGAAACCTTGAAAACGTCGGATACTCTTTGCC
GGGACAAGAAAGCATCTACAACATTATGATTATGGAAGAGGTGCAGACGATTATTGGCATCGGCTGCGGCGCTGCTAGTA
AATTTATTGATCGGGATACAGGGAAAATTACGCATTTTGCGAATCCGAAAGATCCGAAATCGTACAATGAGCGCTTCGAG
CACTACACGGACGAAAAAATCAAATATTTAGAGCAGATTTTTGAAAAAACGACAAAGCAGCACTGA

Upstream 100 bases:

>100_bases
GCGCCCTGACAGGTGCGGCGGCTTTTTTGCCGGATTGATTTTAGCAGTTTATTTCTGTACACTAAAGAAAGTTTTGAATC
TGATAAATTAGGTGATGAAG

Downstream 100 bases:

>100_bases
TTACAGTGCTGCTTTTTTTATCCCTGTTTTTTTGCGGGCTGAACCTCAGGCTTCCATTTAAATACCTTGTTCAGCAAGCG
GTAAATTCGTTTTGATTCCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKE
AFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA
VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSIT
AEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTK
EHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFE
HYTDEKIKYLEQIFEKTTKQH

Sequences:

>Translated_501_residues
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKE
AFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA
VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSIT
AEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTK
EHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFE
HYTDEKIKYLEQIFEKTTKQH
>Mature_501_residues
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKE
AFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA
VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSIT
AEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHL
SRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTK
EHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFE
HYTDEKIKYLEQIFEKTTKQH

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Escherichia coli, GI1789325, Length=308, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082341, Length=238, Percent_Identity=23.9495798319328, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMZ_BACSU (Q796V8)

Other databases:

- EMBL:   Y14080
- EMBL:   Y14080
- EMBL:   AL009126
- PIR:   A69820
- PIR:   H69819
- RefSeq:   NP_388865.1
- ProteinModelPortal:   Q796V8
- EnsemblBacteria:   EBBACT00000002529
- GeneID:   937935
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09840
- NMPDR:   fig|224308.1.peg.984
- GenoList:   BSU09840
- GeneTree:   EBGT00050000002687
- HOGENOM:   HBG313783
- OMA:   NINMDII
- ProtClustDB:   PRK08207
- BioCyc:   BSUB:BSU09840-MONOMER
- BRENDA:   1.3.99.22
- InterPro:   IPR006638
- InterPro:   IPR007197
- SMART:   SM00729

Pfam domain/function: PF04055 Radical_SAM

EC number: =1.3.99.22

Molecular weight: Translated: 57527; Mature: 57527

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: BINDING 174-174 BINDING 186-186 BINDING 233-233 BINDING 267-267 BINDING 295-295 BINDING 307-307 BINDING 332-332

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVK
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLH
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHCCCCHHHHHH
KKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAAVPDLYRVKDEVSIYIGIPFC
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCC
PTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSIT
CCCCCCEECCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENE
HHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
TLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTKEHGYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCCHH
NVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFE
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECCCCCCCHHHHHHHH
HYTDEKIKYLEQIFEKTTKQH
HCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVK
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCC
GTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLH
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHCCCCHHHHHH
KKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAAVPDLYRVKDEVSIYIGIPFC
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCC
PTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSIT
CCCCCCEECCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENE
HHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
TLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTKEHGYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCCHH
NVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFE
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECCCCCCCHHHHHHHH
HYTDEKIKYLEQIFEKTTKQH
HCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751