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The map label for this gene is gntR

Identifier: 16081057

GI number: 16081057

Start: 4113417

End: 4114148

Strand: Direct

Name: gntR

Synonym: BSU40050

Alternate gene names: 16081057

Gene position: 4113417-4114148 (Clockwise)

Preceding gene: 255767863

Following gene: 16081058

Centisome position: 97.58

GC content: 40.98

Gene sequence:

>732_bases
ATGCTAGACTCCAAAGACCTGTTGTATCCCGCAAAATGGCTCTCAAAAGCGTCAACCGGAGTTCGTGTCGCATACGAGCT
GAGAATGCGGATCGTTTCAGGTCTGATTGAAAGCGGTACCATTTTATCAGAAAATACAATCGCCGCCGAGTTTTCAGTAA
GCCGTTCGCCGGTTCGCGAAGCGCTAAAAATACTCGCATCCGAAAAAATCATCCGCTTAGAACGAATGGGAGCGGTCGTA
ATTGGTTTAACTGAGAAGAAAATCGCGGAAATTTATGATGTGCGGTTACTATTAGAAACATTTGTCTTTGAACGGCTTGT
CAAAATAGACATTGAGCCTTTAGTTAAGGATCTCAGCAAAATTCTTGAAATGATGAAAGTCTCAATCAAATATGAGGATG
CTGACGAATTTTCATTTCAAGATGTGCTGTTCCATGAAACGATTATCCGAGCGATTGATCATTCATACATTCAGATGATC
TGGAACAATCTAAAACCCGTCATGGAAAGCTTTATTCTTTTATCGATGCGGGTACGGTTAAAGGAAAAGTATGAAGACTT
CACAAGGATTTTAGATAACCACGAGCTTTATATTCAAGCCATCAAAACAAAGGATAGGGCGCTGATGATTCAGTCTCTTC
ACCAAAACTTTGATGATGTGCAGGATAAGGTAGAAGACCTATGGCTCTCACAACAAATGCTGGCAAAAGGAGCTGAATAC
AACAATGACTAG

Upstream 100 bases:

>100_bases
ATTTAAATAAAAATTAGAAATGAAAGTGTTTGCATAAAAGAAATATTCACGTTATCATACTTGTATACAAGTATACTCCT
TGAGTGAGGAAGGTGAGTGT

Downstream 100 bases:

>100_bases
TTATATGTTAGGAATCGATATCGGCACGACAAGCACAAAAGCTGTGCTGTTCAGTGAAAACGGAGATGTGGTACAGAAAG
AAAGCATCGGCTACCCGCTC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: P28 protein

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSENTIAAEFSVSRSPVREALKILASEKIIRLERMGAVV
IGLTEKKIAEIYDVRLLLETFVFERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI
WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFDDVQDKVEDLWLSQQMLAKGAEY
NND

Sequences:

>Translated_243_residues
MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSENTIAAEFSVSRSPVREALKILASEKIIRLERMGAVV
IGLTEKKIAEIYDVRLLLETFVFERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI
WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFDDVQDKVEDLWLSQQMLAKGAEY
NND
>Mature_243_residues
MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSENTIAAEFSVSRSPVREALKILASEKIIRLERMGAVV
IGLTEKKIAEIYDVRLLLETFVFERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI
WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFDDVQDKVEDLWLSQQMLAKGAEY
NND

Specific function: Transcriptional repressor of the gluconate operon (gntRKPZ), which encodes the proteins for gluconate utilization. Represses mRNA synthesis by binding to the gnt operator; the binding is suppressed by gluconate or glucono-delta-lactone

COG id: COG1802

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): GNTR_BACSU (P10585)

Other databases:

- EMBL:   J02584
- EMBL:   AB005554
- EMBL:   X03510
- EMBL:   AL009126
- PIR:   C26190
- RefSeq:   NP_391885.1
- ProteinModelPortal:   P10585
- SMR:   P10585
- EnsemblBacteria:   EBBACT00000004045
- GeneID:   937710
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40050
- NMPDR:   fig|224308.1.peg.4011
- GenoList:   BSU40050
- GeneTree:   EBGT00050000000782
- HOGENOM:   HBG339552
- OMA:   VLFHETI
- ProtClustDB:   CLSK886028
- BioCyc:   BSUB:BSU40050-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 28279; Mature: 28279

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSENTIAAEFSVSRSPVRE
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCHHHHHH
ALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFVFERLVKIDIEPLVKDLSK
HHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMIWNNLKPVMESFILLSMRVRL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFDDVQDKVEDLWLSQQMLAKGAEY
HHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
NND
CCC
>Mature Secondary Structure
MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSENTIAAEFSVSRSPVRE
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCHHHHHH
ALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFVFERLVKIDIEPLVKDLSK
HHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMIWNNLKPVMESFILLSMRVRL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFDDVQDKVEDLWLSQQMLAKGAEY
HHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
NND
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377; 2419835; 8510140