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The map label for this gene is dltA

Identifier: 16080901

GI number: 16080901

Start: 3952275

End: 3953786

Strand: Direct

Name: dltA

Synonym: BSU38500

Alternate gene names: 16080901

Gene position: 3952275-3953786 (Clockwise)

Preceding gene: 255767815

Following gene: 16080902

Centisome position: 93.75

GC content: 47.95

Gene sequence:

>1512_bases
ATGAAACTTTTACATGCTATTCAAACACATGCGGAAACTTATCCGCAAACCGATGCCTTCCGCTCTCAAGGCCAGTCGCT
CACGTATCAGGAATTATGGGAGCAGTCTGACCGCGCGGCTGCCGCGATCCAAAAACGCATTTCTGGGGAAAAGAAATCTC
CTATCCTTGTGTACGGCCACATGGAGCCGCACATGATCGTTTCCTTCTTGGGAAGTGTCAAAGCGGGACATCCTTATATT
CCGGTTGACCTGTCTATTCCGTCCGAACGGATTGCGAAAATTATCGAAAGCTCTGGAGCAGAATTGCTGATCCATGCAGC
AGGACTCTCAATTGATGCAGTCGGCCAGCAGATTCAGACAGTTTCTGCGGAAGAACTGCTGGAAAACGAAGGCGGCTCTG
TCAGCCAAGATCAATGGGTCAAAGAACACGAAACGTTTTATATCATTTACACTTCCGGGAGCACAGGAAATCCGAAAGGC
GTGCAGATTTCCGCTGCGAACCTTCAAAGCTTCACAGACTGGATTTGTGCAGACTTTCCAGTCAGCGGAGGAAAAATATT
TTTAAACCAAGCGCCGTTCTCATTTGATTTGTCTGTCATGGACCTATATCCGTGCCTTCAATCAGGCGGGACTTTACATT
GCGTGACAAAGGATGCTGTGAATAAGCCGAAAGTCTTATTTGAAGAGCTGAAGAAGTCCGGGCTGAATGTGTGGACATCA
ACACCTTCCTTTGTGCAAATGTGCCTGATGGATCCGGGTTTTTCACAGGATCTGCTGCCTCATGCGGACACATTTATGTT
TTGCGGAGAGGTTCTTCCGGTTTCTGTGGCCAAAGCGCTGCTTGAGCGTTTTCCGAAAGCGAAGATTTTTAATACGTACG
GCCCGACTGAAGCGACAGTGGCTGTCACATCGGTTGAAATTACGAATGACGTCATCAGCCGCAGCGAATCGCTTCCAGTG
GGCTTCGCCAAACCAGATATGAACATTTTCATTATGGATGAAGAGGGACAGCCGCTTCCTGAGGGAGAAAAAGGAGAAAT
CGTCATTGCAGGGCCGAGTGTAAGCCGAGGCTACCTTGGTGAGCCAGAGCTGACGGAAAAAGCGTTTTTCTCTCATGAAG
GCCAGTGGGCATACCGAACTGGCGATGCCGGCTTTATTCAAGACGGTCAGATTTTCTGCCAAGGACGTTTGGATTTTCAG
ATTAAACTTCACGGCTATCGAATGGAGCTGGAGGAAATCGAGTTCCATGTCAGACAGTCACAGTACGTTCGTTCTGCTGT
CGTGATTCCTTATCAGCCAAACGGAACAGTTGAGTATCTGATCGCTGCTATTGTGCCTGAGGAGCATGAGTTCGAGAAGG
AATTCCAGCTGACAAGCGCTATTAAAAAAGAGCTTGCCGCTTCTCTTCCGGCATATATGATCCCGAGAAAATTTATCTAT
CAGGATCACATTCAAATGACGGCTAACGGCAAAATTGACCGAAAACGCATTGGCGAAGAGGTTCTTGTATGA

Upstream 100 bases:

>100_bases
ATTTGATGATACTGCTTGTTTTGTTTTTTATGTATGGTTTTCACACCGCGAATACCGGTTCATATATTTATAACGATTTC
TAATTGGAGAGAGAATAACT

Downstream 100 bases:

>100_bases
CGCCTTACAGCTCGTTTTTATTCTTTATACTGCTTGGCATTCTTCTTCTGCCGACGATCATTCTCGGCTTAAACGGAAAA
AGATTTCAAGCATACAACAT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYI
PVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG
VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTS
TPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPV
GFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQ
IKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIY
QDHIQMTANGKIDRKRIGEEVLV

Sequences:

>Translated_503_residues
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYI
PVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG
VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTS
TPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPV
GFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQ
IKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIY
QDHIQMTANGKIDRKRIGEEVLV
>Mature_503_residues
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYI
PVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG
VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTS
TPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPV
GFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQ
IKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIY
QDHIQMTANGKIDRKRIGEEVLV

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI45580730, Length=379, Percent_Identity=25.3298153034301, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI187761345, Length=448, Percent_Identity=25.4464285714286, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI187761343, Length=448, Percent_Identity=25.4464285714286, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI156151445, Length=387, Percent_Identity=26.6149870801034, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI38505220, Length=499, Percent_Identity=22.0440881763527, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786801, Length=518, Percent_Identity=27.6061776061776, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=24.703557312253, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693145, Length=375, Percent_Identity=24.8, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788107, Length=551, Percent_Identity=22.3230490018149, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786810, Length=510, Percent_Identity=20.9803921568627, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=491, Percent_Identity=23.6252545824847, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17556356, Length=483, Percent_Identity=25.4658385093168, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=410, Percent_Identity=24.6341463414634, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=369, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985884, Length=313, Percent_Identity=24.6006389776358, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=588, Percent_Identity=24.6598639455782, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319699, Length=378, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648676, Length=499, Percent_Identity=28.0561122244489, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI18859661, Length=509, Percent_Identity=24.5579567779961, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355181, Length=395, Percent_Identity=25.3164556962025, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_BACSU (P39581)

Other databases:

- EMBL:   X73124
- EMBL:   AL009126
- PIR:   S39660
- RefSeq:   NP_391729.1
- PDB:   3E7W
- PDB:   3E7X
- PDBsum:   3E7W
- PDBsum:   3E7X
- ProteinModelPortal:   P39581
- SMR:   P39581
- EnsemblBacteria:   EBBACT00000001115
- GeneID:   937358
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU38500
- NMPDR:   fig|224308.1.peg.3855
- GenoList:   BSU38500
- GeneTree:   EBGT00070000032008
- HOGENOM:   HBG320748
- OMA:   HIQMTAN
- ProtClustDB:   PRK04813
- BioCyc:   BSUB:BSU38500-MONOMER
- BRENDA:   6.1.1.13
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01733
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 55809; Mature: 55809

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGH
CHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEC
MEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQT
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
VSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKGVQISAANLQSFTDWICADFP
CCHHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCC
VSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTS
CCCCEEEEECCCCEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEC
TPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATV
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
AVTSVEITNDVISRSESLPVGFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLG
EEEEEEEHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCC
EPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQIKLHGYRMELEEIEFHVRQS
CCCHHHHHHHCCCCCEEEECCCCCEEECCEEEEEECEEEEEEEECEEEEHHHHHHHHHHH
QYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIY
HHHHEEEEEEECCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHH
QDHIQMTANGKIDRKRIGEEVLV
HCCEEEEECCCCCHHHCCHHHCC
>Mature Secondary Structure
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGH
CHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEC
MEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQT
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
VSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKGVQISAANLQSFTDWICADFP
CCHHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCC
VSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTS
CCCCEEEEECCCCEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEC
TPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATV
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
AVTSVEITNDVISRSESLPVGFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLG
EEEEEEEHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCC
EPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQIKLHGYRMELEEIEFHVRQS
CCCHHHHHHHCCCCCEEEECCCCCEEECCEEEEEECEEEEEEEECEEEEHHHHHHHHHHH
QYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIY
HHHHEEEEEEECCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHH
QDHIQMTANGKIDRKRIGEEVLV
HCCEEEEECCCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557