Click here to switch to the map view.

The map label for this gene is glyA

Identifier: 16080743

GI number: 16080743

Start: 3789190

End: 3790437

Strand: Reverse

Name: glyA

Synonym: BSU36900

Alternate gene names: 16080743

Gene position: 3790437-3789190 (Counterclockwise)

Preceding gene: 16080744

Following gene: 16080742

Centisome position: 89.91

GC content: 45.75

Gene sequence:

>1248_bases
ATGAAACATTTACCTGCGCAAGACGAACAAGTGTTTAACGCCATTAAAAATGAGCGTGAACGCCAACAGACTAAGATCGA
ATTGATTGCTTCTGAGAACTTTGTAAGTGAAGCGGTTATGGAAGCACAAGGATCTGTTTTGACAAATAAGTACGCAGAAG
GATATCCGGGCAAACGCTACTACGGCGGATGCGAGCACGTCGATGTCGTTGAAGATATCGCCCGTGACCGCGCGAAGGAA
ATCTTTGGAGCGGAGCATGTAAACGTTCAGCCTCATTCAGGCGCACAAGCAAACATGGCAGTGTACTTCACGATTTTGGA
GCAAGGCGATACTGTACTTGGGATGAACCTCTCCCACGGCGGCCATTTAACACACGGAAGCCCAGTCAACTTCAGCGGTG
TTCAATATAACTTTGTTGAGTACGGCGTAGATAAAGAAACTCAATATATTGATTACGATGACGTGCGTGAAAAAGCCCTC
GCTCATAAACCGAAGCTTATCGTAGCAGGAGCAAGTGCGTATCCTCGTACAATCGACTTTAAGAAATTCCGTGAAATTGC
TGATGAAGTCGGCGCTTACTTCATGGTGGATATGGCACATATCGCAGGACTTGTTGCGGCAGGCCTTCATCCAAACCCGG
TTCCTTACGCTGATTTCGTTACAACAACAACACATAAAACACTTCGCGGTCCTCGCGGCGGTATGATCCTTTGCCGTGAA
GAGTTTGGCAAGAAAATTGATAAATCGATCTTCCCTGGAATTCAAGGCGGCCCTCTGATGCACGTTATTGCCGCAAAAGC
TGTTTCATTCGGTGAAGTATTGCAGGACGATTTCAAAACATATGCACAAAACGTCATTTCAAACGCGAAACGTCTGGCTG
AAGCCTTAACGAAAGAGGGCATCCAGCTCGTTTCAGGCGGAACAGACAACCACCTTATCCTTGTTGACCTTCGTTCGCTC
GGACTGACTGGTAAGGTTGCGGAGCATGTACTTGATGAAATTGGTATTACGTCTAACAAAAACGCGATTCCATATGATCC
TGAAAAACCTTTCGTAACAAGCGGCATCCGTCTTGGTACAGCTGCTGTAACCAGCCGCGGTTTTGACGGAGACGCATTAG
AAGAAGTCGGTGCTATCATTGCGCTTGCATTGAAAAACCACGAAGATGAAGGAAAACTTGAAGAAGCAAGACAGCGTGTA
GCTGCTCTGACTGATAAATTTCCTTTATATAAAGAATTAGATTATTAA

Upstream 100 bases:

>100_bases
AGATTTTTTAAAAATAATCTTTTACATCGGCCTTAAAAACCATGTACAATAGTGATGGTAAAAACAAAGAACAGGATACG
GATAGGAGAGGATCTCGCTG

Downstream 100 bases:

>100_bases
GATCCTAAAACCCGCTTGGGCTTATGCCCGGCGGGTTTTTTGACGATGTTCTTGAAACTCAATGTCTTTTTTTGTAGAAT
CAATAGAAGTGTGTAATTGT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL
AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSL
GLTGKVAEHVLDEIGITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEEARQRV
AALTDKFPLYKELDY

Sequences:

>Translated_415_residues
MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL
AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSL
GLTGKVAEHVLDEIGITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEEARQRV
AALTDKFPLYKELDY
>Mature_415_residues
MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL
AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSL
GLTGKVAEHVLDEIGITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEEARQRV
AALTDKFPLYKELDY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862352, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862350, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862348, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI22547186, Length=435, Percent_Identity=45.0574712643678, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI261862346, Length=447, Percent_Identity=41.834451901566, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI22547189, Length=420, Percent_Identity=43.8095238095238, Blast_Score=307, Evalue=1e-83,
Organism=Escherichia coli, GI1788902, Length=406, Percent_Identity=58.6206896551724, Blast_Score=474, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=48.8778054862843, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=48.8778054862843, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319739, Length=422, Percent_Identity=45.9715639810426, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=390, Percent_Identity=46.1538461538462, Blast_Score=331, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24640005, Length=448, Percent_Identity=43.9732142857143, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221329721, Length=448, Percent_Identity=43.9732142857143, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45490; Mature: 45490

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKALAHKPKLIVAGASAYPRTIDF
CCCCCCCCCCCCCEEEEHHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEHH
EFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEG
HHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEIGITSNKNAIPYDPEKPFVTSGIRLGT
EEEECCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCH
AAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEEARQRVAALTDKFPLYKELDY
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKALAHKPKLIVAGASAYPRTIDF
CCCCCCCCCCCCCEEEEHHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEHH
EFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEG
HHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEIGITSNKNAIPYDPEKPFVTSGIRLGT
EEEECCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCH
AAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEEARQRVAALTDKFPLYKELDY
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA