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The map label for this gene is ywqF

Identifier: 16080676

GI number: 16080676

Start: 3729488

End: 3730810

Strand: Reverse

Name: ywqF

Synonym: BSU36230

Alternate gene names: 16080676

Gene position: 3730810-3729488 (Counterclockwise)

Preceding gene: 16080677

Following gene: 16080675

Centisome position: 88.5

GC content: 47.69

Gene sequence:

>1323_bases
ATGAATATAACAGTCATCGGAACAGGCTATGTCGGTCTTGTGACAGGTGTTTCTCTTTCTGAGATTGGACATCATGTAAC
CTGCATTGATATTGACGCTCACAAGATTGATGAAATGAGAAAGGGCATTTCCCCCATATTTGAACCAGGTCTTGAAGAGC
TGATGAGAAAAAATACAGCTGATGGACGGCTGAACTTTGAAACGAGCTATGAGAAAGGCTTGGCACAGGCAGACATCATT
TTTATAGCGGTCGGCACACCGCAGAAAAGCGACGGGCACGCCAATCTGGAGCAAATTACAGATGCGGCCAAACGCATCGC
AAAGCATGTCAAACGAGATACAGTCGTGGTAACGAAAAGCACAGTGCCCGTTGGGACAAACGATTTGATTAATGGACTGA
TTACTGAACATCTAGCGGAGCCTGTCAGTATTTCGGTCGCATCCAATCCGGAATTTTTGCGTGAGGGGTCGGCGATCTAT
GATACCTTTCATGGTGACAGGATCGTGATCGGGACGGCCGATGAGAAAACAGCAAATACGCTGGAGGAGCTCTTCCGTCC
GTTTCAAATCCCGATTTACCAAACGGATATCAGAAGCGCCGAGATGATCAAATATGCCTCAAATGCTTTTCTGGCCACTA
AGATCAGTTTTATAAACGAAATTTCGAATATATGTGAAAAGGTCGGCGCCGATATTGAAGCAGTCGCATACGGGATGGGA
CAGGATAAGCGGATCGGGAGCCAGTTTTTAAAAGCGGGCATAGGCTACGGCGGCTCTTGTTTTCCAAAGGACACAAACGC
CCTCGTGCAAATTGCCGGCAATGTCGAGCATGATTTTGAACTGCTGAAATCCGTTATCAAAGTCAACAACAATCAGCAGG
CGATGCTGGTTGATAAAGCGCTGAACAGGCTCGGTGGGGTGACGGGAAAAACGATTGCCCTTTTAGGCCTGTCATTTAAA
CCGAATACCGACGATATGAGAGAAGCGCCGTCAATTGTTATTGCAGACCGTCTCGCTGCGCTCGACGCCCGTATCAGAGC
CTACGATCCCATTGCAGTTAGCCATGCAAAGCATGTTCTCCCGCAAGCTGTTGAATATAAAGAGACGATCGAGGAAGCTG
TCAAAGGGTCTGACGCCGTCATGATTTTAACCGACTGGGCTGACATTAAACAATTCCCGTTAGCGGCTTATCAGGATTTG
ATGGAAACGCCGCTCATATTTGACGGCAGAAACTGCTACACATTGGATGAGGCTTTGGCTGCAGGAGTGGAGTATTATTC
TGTCGGACGGAAGGCGGTTGTTCCGTCAGGTGCAATTCAATAG

Upstream 100 bases:

>100_bases
CCGACAGGCTATGCGGGAGATCATTCGCATTCATGATAGGATGTTCTCATACGATATTACGGAAGCTGCAAAGCAGCAAT
TTAACTGTTGGAGGGAAACA

Downstream 100 bases:

>100_bases
ATGAAAAAGAAAGGCTGGTTGCGCACCAGTCTTTTTTTCATCTATTGCGGGGTGCTGAATACATTTGCTACTATTTAACT
ATTGTTTGGAAAATTATGCA

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGISPIFEPGLEELMRKNTADGRLNFETSYEKGLAQADII
FIAVGTPQKSDGHANLEQITDAAKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY
DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFINEISNICEKVGADIEAVAYGMG
QDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVEHDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFK
PNTDDMREAPSIVIADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQFPLAAYQDL
METPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ

Sequences:

>Translated_440_residues
MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGISPIFEPGLEELMRKNTADGRLNFETSYEKGLAQADII
FIAVGTPQKSDGHANLEQITDAAKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY
DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFINEISNICEKVGADIEAVAYGMG
QDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVEHDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFK
PNTDDMREAPSIVIADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQFPLAAYQDL
METPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ
>Mature_440_residues
MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGISPIFEPGLEELMRKNTADGRLNFETSYEKGLAQADII
FIAVGTPQKSDGHANLEQITDAAKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY
DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFINEISNICEKVGADIEAVAYGMG
QDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVEHDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFK
PNTDDMREAPSIVIADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQFPLAAYQDL
METPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=480, Percent_Identity=35.2083333333333, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI296040438, Length=377, Percent_Identity=35.2785145888594, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI296040443, Length=334, Percent_Identity=37.4251497005988, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=30.0561797752809, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994968, Length=409, Percent_Identity=28.1173594132029, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=438, Percent_Identity=36.5296803652968, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=33.6933045356371, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YWQF_BACSU (P96718)

Other databases:

- EMBL:   Z92952
- EMBL:   AL009126
- PIR:   A70067
- RefSeq:   NP_391504.1
- HSSP:   P11759
- ProteinModelPortal:   P96718
- SMR:   P96718
- PhosSite:   P96718
- EnsemblBacteria:   EBBACT00000002831
- GeneID:   936890
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU36230
- NMPDR:   fig|224308.1.peg.3630
- GenoList:   BSU36230
- GeneTree:   EBGT00050000001585
- HOGENOM:   HBG400967
- OMA:   VEHDFEL
- PhylomeDB:   P96718
- ProtClustDB:   CLSK888013
- BioCyc:   BSUB:BSU36230-MONOMER
- BRENDA:   1.1.1.22
- GO:   GO:0005737
- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:1.20.5.100
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: =1.1.1.22

Molecular weight: Translated: 47784; Mature: 47784

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: ACT_SITE 260-260

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGISPIFEPGLEELMRKNTA
CEEEEEECCHHHHHHCCCHHHCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDAAKRIAKHVKRDTVVVTKS
CCEEEECCHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
TVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIYDTFHGDRIVIGTADEKTANT
CCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCHHEEECCCCEEEEECCCCHHHHH
LEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFINEISNICEKVGADIEAVAYGMG
HHHHHCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
QDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVEHDFELLKSVIKVNNNQQAMLVDKA
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHH
LNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVIADRLAALDARIRAYDPIAVSHAKHVL
HHHHCCCCCCEEEEEEECCCCCCCHHHHCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
PQAVEYKETIEEAVKGSDAVMILTDWADIKQFPLAAYQDLMETPLIFDGRNCYTLDEALA
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHHHHCCCEECCCCCEEHHHHHH
AGVEYYSVGRKAVVPSGAIQ
CCCHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGISPIFEPGLEELMRKNTA
CEEEEEECCHHHHHHCCCHHHCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDAAKRIAKHVKRDTVVVTKS
CCEEEECCHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
TVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIYDTFHGDRIVIGTADEKTANT
CCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCHHEEECCCCEEEEECCCCHHHHH
LEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFINEISNICEKVGADIEAVAYGMG
HHHHHCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
QDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVEHDFELLKSVIKVNNNQQAMLVDKA
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHH
LNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVIADRLAALDARIRAYDPIAVSHAKHVL
HHHHCCCCCCEEEEEEECCCCCCCHHHHCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
PQAVEYKETIEEAVKGSDAVMILTDWADIKQFPLAAYQDLMETPLIFDGRNCYTLDEALA
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHHHHCCCEECCCCCEEHHHHHH
AGVEYYSVGRKAVVPSGAIQ
CCCHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377