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The map label for this gene is apt

Identifier: 16079815

GI number: 16079815

Start: 2822901

End: 2823413

Strand: Reverse

Name: apt

Synonym: BSU27610

Alternate gene names: 16079815

Gene position: 2823413-2822901 (Counterclockwise)

Preceding gene: 16079816

Following gene: 255767631

Centisome position: 66.98

GC content: 44.05

Gene sequence:

>513_bases
ATGGATTTAAAACAATACGTAACAATTGTACCGGATTACCCGAAAGAGGGCGTGCAATTTAAAGATATTACGACACTGAT
GGATAAAGGCGATGTATACCGCTATGCCACAGATCAAATTGTTGAATATGCGAAAGAAAAGCAAATTGATTTGGTCGTTG
GCCCTGAAGCGCGCGGCTTTATTATCGGCTGTCCCGTTGCTTACGCGCTTGGCGTAGGTTTTGCGCCGGTCCGCAAAGAA
GGCAAGTTGCCTCGTGAAGTAATCAAAGTGGATTATGGCTTGGAATACGGAAAAGACGTATTAACGATCCACAAAGATGC
GATTAAGCCTGGTCAGCGTGTGCTTATTACAGATGACCTGCTTGCGACAGGCGGCACAATTGAAGCGACAATCAAACTTG
TTGAAGAACTTGGCGGCGTTGTTGCTGGTATCGCTTTCTTAATCGAGCTTTCTTACCTTGACGGCAGAAATAAGCTCGAA
GATTACGACATCTTAACATTGATGAAATACTAA

Upstream 100 bases:

>100_bases
AGCTGAATTATTCTTCTGCTGAAGAGCTGAAGGAATGGCTGAATAAGCTGATGAAACAAGATTCAGAGGCTTATGAAAGT
ACGAGGAGGACATAAAACAG

Downstream 100 bases:

>100_bases
GGATAACCGCATAACGAAAAAGCACTCCATGTCAGGGTGCTTTTTTCCTATTGTTTTGCATTTATTTTATATAATATTTG
GCTATTTGAACTTCTGCTCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE
DYDILTLMKY

Sequences:

>Translated_170_residues
MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE
DYDILTLMKY
>Mature_170_residues
MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE
DYDILTLMKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=39.766081871345, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=41.6, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=55.4878048780488, Blast_Score=172, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=42.9411764705882, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=40.6976744186046, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=37.012987012987, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136334, Length=162, Percent_Identity=42.5925925925926, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18875; Mature: 18875

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKQIDLVVGPEARGF
CCCHHEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLEDYDILTLMKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYAKEKQIDLVVGPEARGF
CCCHHEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLEDYDILTLMKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA