Click here to switch to the map view.

The map label for this gene is bsaA

Identifier: 16079249

GI number: 16079249

Start: 2304553

End: 2305035

Strand: Reverse

Name: bsaA

Synonym: BSU21900

Alternate gene names: 16079249

Gene position: 2305035-2304553 (Counterclockwise)

Preceding gene: 16079253

Following gene: 16079248

Centisome position: 54.68

GC content: 41.61

Gene sequence:

>483_bases
ATGTCTATTTATCATATGAAGGTACGTACAATCACAGGGAAAGACATGACACTTCAGCCTTTCGCGGGAAAGGTACTGAT
GATCGTGAATACAGCAAGTAAGTGCGGTTTTACTTCCCAATTGAAGCAGCTGCAGGAATTATATGATACATATCAGCAGG
AGGGGCTGGAGATCTTAGGGTTCCCCTGCAATCAATTCATGAACCAAGAGCCTGGTGAAGAGGCTGACATACAGGAATTT
TGTGAAACAAATTACGGTGTTACATTTCCTATGTTTTCAAAAGTGGATGTAAACGGGAAAAACGCCCACCCGCTGTTTGT
GTATTTGACAGAACATGCGAAAGGGATGCTGGGAACTAAGGCGATCAAGTGGAATTTCACGAAATTTATAGTGGATAGAA
ATGGAGAAATCGTTGGCCGTTATTCACCAAATACAAATCCGAAAGAGTTGGAAGACGATATCGTGAAGCTATTAGAGCAA
TAA

Upstream 100 bases:

>100_bases
ATCGTTAGGTTTCTTATGAGTTCTTAATTGATGTTTACATTTTGAATTGCGATTTAAAAAAGGTAAAATAATCAGCACCA
AGGACATAGGAGGGACTTAC

Downstream 100 bases:

>100_bases
AAAGAGGGTGTTTTTGTGAAGGAATTGAAGCAGGCAGAGCAAATCAGGACATGGGTTCAATCTATCCTGACTGACGAAAG
CTCTGGACATGACTGGCATC

Product: peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQLQELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEF
CETNYGVTFPMFSKVDVNGKNAHPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ

Sequences:

>Translated_160_residues
MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQLQELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEF
CETNYGVTFPMFSKVDVNGKNAHPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ
>Mature_159_residues
SIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQLQELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFC
ETNYGVTFPMFSKVDVNGKNAHPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family

Homologues:

Organism=Homo sapiens, GI75709200, Length=156, Percent_Identity=44.2307692307692, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI90903240, Length=156, Percent_Identity=44.2307692307692, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI15618997, Length=158, Percent_Identity=38.6075949367089, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI192455698, Length=160, Percent_Identity=33.75, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI90903238, Length=131, Percent_Identity=45.0381679389313, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4557629, Length=164, Percent_Identity=33.5365853658537, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=34.7826086956522, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI6006001, Length=179, Percent_Identity=32.4022346368715, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI33186887, Length=179, Percent_Identity=29.608938547486, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI32967607, Length=182, Percent_Identity=30.2197802197802, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1788003, Length=173, Percent_Identity=43.3526011560694, Blast_Score=148, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=158, Percent_Identity=48.1012658227848, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=45.9119496855346, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71993584, Length=158, Percent_Identity=41.1392405063291, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193210707, Length=164, Percent_Identity=44.5121951219512, Blast_Score=139, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17550320, Length=163, Percent_Identity=31.9018404907975, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI193209493, Length=163, Percent_Identity=31.2883435582822, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71993573, Length=95, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=38.1578947368421, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=159, Percent_Identity=51.5723270440252, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322228, Length=151, Percent_Identity=51.6556291390728, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322826, Length=149, Percent_Identity=45.6375838926174, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24656772, Length=161, Percent_Identity=44.7204968944099, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656777, Length=161, Percent_Identity=44.7204968944099, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24656767, Length=161, Percent_Identity=44.7204968944099, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI85726443, Length=165, Percent_Identity=44.2424242424242, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BSAA_BACSU (P52035)

Other databases:

- EMBL:   L77246
- EMBL:   AL009126
- PIR:   E69596
- RefSeq:   NP_390073.1
- ProteinModelPortal:   P52035
- SMR:   P52035
- PeroxiBase:   3984
- EnsemblBacteria:   EBBACT00000003739
- GeneID:   939086
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU21900
- NMPDR:   fig|224308.1.peg.2196
- GenoList:   BSU21900
- GeneTree:   EBGT00050000002571
- HOGENOM:   HBG648990
- OMA:   NTASECA
- PhylomeDB:   P52035
- ProtClustDB:   CLSK887471
- BioCyc:   BSUB:BSU21900-MONOMER
- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR11592
- PIRSF:   PIRSF000303
- PRINTS:   PR01011

Pfam domain/function: PF00255 GSHPx; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.9

Molecular weight: Translated: 18256; Mature: 18125

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1; PS00763 GLUTATHIONE_PEROXID_2; PS51355 GLUTATHIONE_PEROXID_3

Important sites: ACT_SITE 35-35

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQLQELYDTYQQEGLEILG
CCEEEEEEEEECCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
FPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNAHPLFVYLTEHAKGMLGTK
CCHHHHCCCCCCCCCCHHHHHHCCCCEEECCCEEEECCCCCCCEEEEEEECCCCCCCCCE
AIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ
EEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQLQELYDTYQQEGLEILG
CEEEEEEEEECCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
FPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNAHPLFVYLTEHAKGMLGTK
CCHHHHCCCCCCCCCCHHHHHHCCCCEEECCCEEEECCCCCCCEEEEEEECCCCCCCCCE
AIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ
EEEEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377