Click here to switch to the map view.

The map label for this gene is ppsE

Identifier: 16078891

GI number: 16078891

Start: 1960198

End: 1964037

Strand: Reverse

Name: ppsE

Synonym: BSU18300

Alternate gene names: 16078891

Gene position: 1964037-1960198 (Counterclockwise)

Preceding gene: 255767428

Following gene: 16078890

Centisome position: 46.59

GC content: 44.87

Gene sequence:

>3840_bases
GTGAAGAAAGGTGCAGACACTATGAATACCATTAAAAAAATCAAGAACATTTATCCTCTGAGTCATATGCAGGAAGGGAT
GCTGTTTCATTCCTTCCTCCGTAAAGAGGAGGGGGCGTATGTTGAGCAGTCGCTCTTCACCATTAAAGGAAGCCTCAGCT
ATGACTGGTTCCAGCGCAGCATTCAAGCCATTATCGACCGCCATGATATTTTCAGAACCGTGTTTTTGCCGCACGTCCCG
CATTTGTCGGGACCTCGGCAAGTCGTGATGACAGAACGTGAATTCCATTTGAACAGCGAAGACATTTCTCATCTGCCGAC
AAACGACCAGAATGAGTATATTGAACGCTTTAAAGAGAAGGACAAGCAAAAAGGCTTTGATCTGCAAAAAGACATGCTGA
TGCGGATTTCTCTATTCAAAACAGCTAAAGATGAGCATGTCTGTATCTGGAGTCACCATCACATTTTAATGGACGGATGG
TGCCTAGGTATCGTTATGCAGGAATTTATGCAAATTTATCAATCGATTCATGCAGGAAAACCGCTTTCATTAGACCCTGT
CCGTCCGTACAGCACCTATATTTCATGGCTGACAAACCGAGACAAAGAAAAAGCAGCGGCCTACTGGGATACCTATTTAA
AAAACTACAGCGCTCCATCACCTCTGCCTCGTGTGTCTGATAAAGAAACAAAAGAAAGTTATCACCGTGAAGATTTGATA
TTTTCATTAAATAAACCACTGACAGACAAGCTGAAAGAGACTGCCAAACAACACGGCGTCACGCTCGCTACCCTTATTCA
GGCAGTCTGGGGTGTGATGCTGCAGCAATATAACCGCACAGACGACGTTGTGTTTGGCGCAGTTGTATCAGGAAGACCGT
CAGAAATCCCAGGCGTGGAGCAAATGATAGGGTTGTTTATCAATACCATACCGATTCGAATTAAAACACACCAAGACGAA
ACGTTTCACGAGCTGCTCATACGCTGCCAGAAAGAAATGCTGGAAGCTGAGCCGTTTACCTGCCAGCCTTTATTTGATAT
TCAGGCAAACACCGCATTAAAACAGGAACTGATTGATCACATTATCGTCTTTGAAAACTATCCGTTACAGCAGAAAATCG
CCGATTCCGCTGATCAAACCGATTCACCGCTGCAAATCGATCAAGTTCAAGTATCCGAGCAATCAGGATATAACTTTAAT
CTTGTCGTTGCTCCTGGCGAAGAGCTTGTCATCAAGTTCAGCTATAATGCATTCGTTTACGATGCTGCCTGGATCAGCTG
TATCAAGAGGCAATTTACGCAAGCGCTTAGCACAGCTGCACAGCACCCTCATATGCCAATTGCTGATTTTTCTTTTCTTG
ATGCAACAGAAAAAGAGCAGATTGTCACACAGTTCAACAATACAAAAACGGAGTATCCAAAGAATCATACAATTATCGAT
TTATTTCGCGAACAAGCAGAAAAGACGCCAGACCATACCGCACTTGTGTATGGCAATATGTCTATTTCGTATAAAGAGCT
TGATAAACGCTCTAATGCGCTCGCCAGAGAGTTAATTCAAAAGGGATTTCGGAAAAACGAGACAGCCGGAATATTGGCTG
CACATTCTCCCGAATTCATGATCAGTGTGCTTGCCGTATTAAAAGCAGGGGGAGCATACCTCCCGCTTGATGCGGAGCTT
CCGCCTGAACGAGTCAGCTTTATGCTTGAGGAAACGCAGGCAAAAATGCTGATTGTTCAAAAGGGATTGGAGCAAAACGC
TGCGTTCTCAGGAACATGTATCATTTCAGATGCGCAGGGATTGATGGAAGAGAACGATATCCCTATTAATATCAGCTCCA
GCCCGGATGATCTTGCGTACATCATGTATACCTCAGGATCAACAGGCCGGCCGAAAGGGGTCATGATCACGAATCGCAAT
GTCGTGTCCCTTGTCAGAAACAGCAATTACACGTCTGCGTCCGGTGATGACCGGTTTATTATGACTGGATCTATCAGCTT
TGACGCCGTCACCTTTGAAATGTTCGGGGCACTTTTAAATGGCGCAAGCCTTCATATCATTGATAAATCGACAATGCTGA
CACCTGATCGGTTTGGAGCGTATTTGCTTGAAAATGACATTACAGTGCTATTTTTAACGACAGCTCTTTTTAATCAGCTG
GCACAGGTACGAGCTGACATGTTTCGCGGACTCCATACGTTATATGTCGGAGGAGAAGCACTCTCTCCTGCCCTGATGAA
TGCCGTCAGACACGCCTGTCCAGATCTCGCGCTTCATAATATTTACGGGCCAACGGAAAACACGACTTTTTCAACCTTTT
TTGAAATGAAGAGAGACTATGCGGGGCCGATTCCGATTGGAAAACCAATCAGTAATAGCACCGCTTACATCTTAGATACA
AAAGGACGTCTTTTGCCAATAGGCGTTCCCGGCGAGCTTTGTGTTGGCGGTGATGGAGTCGCTAAAGGCTATTTGAACAG
AGTAGATCTGACAAATGCTGTGTTTTCTCCTCATCCTTTCTTGCCTGGAGAAAGAATATACCGTACTGGTGATTTGGCGC
GCTGGCTGCCTGATGGAAACTTAGAATACATCAGCAGAATTGACAGGCAAATGAAAATCCGCGGAAAACGAATTGAGCCT
GCCGAAATAGAAGCGCGCCTGTTAGAAATGGAAGGCGTTCAAGAAGCAGCAGTGACATTGAGAGAAAAAGATGGAGAGGC
GCAGCTGTACACTCATTACGTCGGTGATCACAAAAAAACAGATACGGATTTTCGCGCCGATTTGGCGCGTGTGCTTCCAG
ACTATATGATCCCGCAGCACTGGGTGCGTGTGGAGCGGATGCCGCTTACCGGAAACGGAAAAATAGACCGCAGCGCGCTG
CCTATTCCAGAAAATAAGCCTGCCAAACGACAGAACATCATATTGCCAAGAAACTTGGTTGAAGAAGAATTGGCGAACAT
TTGGAAGCAAGTCCTCGGTGTTAACACAATCAGTATTGATGATGACTTCTTTGCTATTGGCGGACATTCACTAAGAGCAC
TGCAAGTCATACATACACTAAAACATCAGCAGAACATTGACATACCGATTGATTTCTTGTTCGAACATCCGACAATCGCT
CAGCTTGCCGAAAAACTTTATTCTAAACAGCTGACAGCAGCAAATGAACAGCATGTGATCAAACTGAACCAGCACGGCGC
GCAAAATCTTTTCTGCTTCCCGCCGATATCGGGATTTGGCATTTATTTTAAAGACCTTGCTTTATTGCTGAATGAGAAGG
CAGCCGTATACGGGTTTCACTTTATTGAACAAGACACCCGCATTGAACAATATGTTAATTGCATGACGGACATACAGCCT
GAGGGCCCATACGTTTTATTAGGCTACTCTGCAGGCGGAAACCTGGCTTTTGAAGTGGCACAGGCTATGGAGCGCAAAGG
ATTAGAAGTCAGCGACTTCATTATCGTGGACGCTTATCTAAAAGAACAGCCTTTGCCTATCGATACCGGTAATGACGAAT
CTGCAGCATATCTGCCTGAAGCAGTCAGAGAAAAGGTGATGAAGAAAAAAAGAAACTATCAGGAATATTGGGCACAATTG
CTGAATGAAGGCCACATCAAAGCAAGCATTCATTTCATCGAAGCTGGAATCCACCCCGAAACCAGCGGGCATACAGGCTT
AACGAAATGGGAAGGCGCCTGCGGAAACTATAGTGAGTACACGGGTTTTGGCGCTCATAAAGACATGCTGGAAGGAACAT
ATGCTGAAAAGAATGCCGACATCATCCTCGACATTTTAGAAAAGATCACTTCAAATCAAGTAATACTGCACAAACGATAA

Upstream 100 bases:

>100_bases
AGCGAAACAGAAAAGACGATCAGTGATTTTGATGATCAAGAACTGACCGAGGACGCCCTGCAAGAGATCGCTGATATGCT
CAGTTTTCACTAATGAATCC

Downstream 100 bases:

>100_bases
AGCGGATTAGCGGACAGAGGCCATTCTCTGTCCGTCTTTCTTTTTGTATCAAGAATGGATAAGGGACACTTGGGAATGAT
AACATCATCCTTTTTCTTGG

Product: plipastatin synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Peptide synthase 5; ATP-dependent isoleucine adenylase; IsoA; Isoleucine activase

Number of amino acids: Translated: 1279; Mature: 1279

Protein sequence:

>1279_residues
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVP
HLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW
CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLI
FSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDE
TFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFN
LVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIID
LFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAEL
PPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRN
VVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQL
AQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDT
KGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEP
AEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSAL
PIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIA
QLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQP
EGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQL
LNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR

Sequences:

>Translated_1279_residues
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVP
HLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW
CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLI
FSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDE
TFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFN
LVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIID
LFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAEL
PPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRN
VVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQL
AQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDT
KGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEP
AEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSAL
PIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIA
QLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQP
EGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQL
LNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR
>Mature_1279_residues
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVP
HLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW
CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLI
FSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDE
TFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFN
LVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIID
LFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAEL
PPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRN
VVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQL
AQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDT
KGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEP
AEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSAL
PIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIA
QLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQP
EGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQL
LNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR

Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acid Ile as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The activation sites for this amino acid consist of individual domains

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain

Homologues:

Organism=Homo sapiens, GI45580730, Length=555, Percent_Identity=23.0630630630631, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI38505220, Length=530, Percent_Identity=23.7735849056604, Blast_Score=98, Evalue=7e-20,
Organism=Homo sapiens, GI157311624, Length=521, Percent_Identity=21.1132437619962, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI157311622, Length=521, Percent_Identity=21.1132437619962, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI38524616, Length=547, Percent_Identity=23.217550274223, Blast_Score=70, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=1195, Percent_Identity=27.2803347280335, Blast_Score=346, Evalue=4e-96,
Organism=Escherichia coli, GI145693145, Length=527, Percent_Identity=23.5294117647059, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1788107, Length=548, Percent_Identity=22.6277372262774, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=1207, Percent_Identity=22.4523612261806, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17556356, Length=676, Percent_Identity=26.6272189349112, Blast_Score=159, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71994703, Length=546, Percent_Identity=21.978021978022, Blast_Score=99, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=546, Percent_Identity=21.978021978022, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=546, Percent_Identity=21.978021978022, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=599, Percent_Identity=21.2020033388982, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564420, Length=461, Percent_Identity=23.4273318872017, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32564422, Length=461, Percent_Identity=23.4273318872017, Blast_Score=80, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=527, Percent_Identity=22.3908918406072, Blast_Score=80, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147511, Length=189, Percent_Identity=30.6878306878307, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=458, Percent_Identity=22.0524017467249, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=458, Percent_Identity=22.0524017467249, Blast_Score=74, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=764, Percent_Identity=25.7853403141361, Blast_Score=241, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319699, Length=486, Percent_Identity=23.2510288065844, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648676, Length=637, Percent_Identity=26.8445839874411, Blast_Score=174, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24582852, Length=567, Percent_Identity=24.8677248677249, Blast_Score=92, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581924, Length=512, Percent_Identity=21.6796875, Blast_Score=91, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21355181, Length=518, Percent_Identity=23.7451737451737, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPSE_BACSU (O31827)

Other databases:

- EMBL:   Y13917
- EMBL:   AL009126
- PIR:   E69681
- RefSeq:   NP_389712.1
- HSSP:   P0C062
- ProteinModelPortal:   O31827
- EnsemblBacteria:   EBBACT00000002340
- GeneID:   939956
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18300
- GenoList:   BSU18300
- GeneTree:   EBGT00070000032008
- HOGENOM:   HBG547964
- OMA:   RQYEYSS
- ProtClustDB:   CLSK886678
- BioCyc:   BSUB:BSU18300-MONOMER
- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031
- Gene3D:   G3DSA:1.10.1200.10
- PRINTS:   PR00154
- TIGRFAMs:   TIGR01733

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase; SSF47336 ACP_like

EC number: 2.7.7.- [C]

Molecular weight: Translated: 144621; Mature: 144621

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50075 ACP_DOMAIN; PS00455 AMP_BINDING; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRS
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCHHHHHHH
IQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEK
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHCCCCHHHCCCCCCCHHHHHHHHHHH
DKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGWCLGIVMQEFMQIYQSIHAGK
HHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCC
PLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLI
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHE
FSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVE
EECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHH
QMIGLFINTIPIRIKTHQDETFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDH
HHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHH
IIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFNLVVAPGEELVIKFSYNAFVY
EEEECCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEE
DAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIID
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCCCHHHH
LFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFM
HHHHHHHCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ISVLAVLKAGGAYLPLDAELPPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQG
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHH
LMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFI
HHCCCCCCEEECCCCCCEEEEEEECCCCCCCCEEEEECCCEEEHHHCCCCCCCCCCCCEE
MTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQL
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCEEECCCCEEEHHHHHHHHHH
AQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDY
HHHHHHHHCCHHEEEECCHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHC
AGPIPIGKPISNSTAYILDTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPF
CCCCCCCCCCCCCEEEEEECCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCC
LPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTL
CCCCCEEECCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHH
REKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSAL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCCCCCC
PIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTL
CCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHH
KHQQNIDIPIDFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFG
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCH
IYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVA
HHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
QAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQL
HHHHHCCCCEEHEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
LNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNAD
HCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCH
IILDILEKITSNQVILHKR
HHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRS
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCCHHHHHHH
IQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEK
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHCCCCHHHCCCCCCCHHHHHHHHHHH
DKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGWCLGIVMQEFMQIYQSIHAGK
HHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCC
PLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLI
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHE
FSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVE
EECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHH
QMIGLFINTIPIRIKTHQDETFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDH
HHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHH
IIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFNLVVAPGEELVIKFSYNAFVY
EEEECCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEE
DAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIID
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCCCHHHH
LFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFM
HHHHHHHCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ISVLAVLKAGGAYLPLDAELPPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQG
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHH
LMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFI
HHCCCCCCEEECCCCCCEEEEEEECCCCCCCCEEEEECCCEEEHHHCCCCCCCCCCCCEE
MTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQL
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCEEECCCCEEEHHHHHHHHHH
AQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDY
HHHHHHHHCCHHEEEECCHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHC
AGPIPIGKPISNSTAYILDTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPF
CCCCCCCCCCCCCEEEEEECCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCC
LPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTL
CCCCCEEECCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHH
REKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSAL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCCCCCC
PIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTL
CCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHH
KHQQNIDIPIDFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFG
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCH
IYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVA
HHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
QAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQL
HHHHHCCCCEEHEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
LNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNAD
HCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCH
IILDILEKITSNQVILHKR
HHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377; 10471562