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The map label for this gene is pyrD

Identifier: 16078618

GI number: 16078618

Start: 1627718

End: 1628653

Strand: Direct

Name: pyrD

Synonym: BSU15540

Alternate gene names: 16078618

Gene position: 1627718-1628653 (Clockwise)

Preceding gene: 16078617

Following gene: 16078619

Centisome position: 38.61

GC content: 47.86

Gene sequence:

>936_bases
ATGCTAGAGGTGAAATTGCCGGGACTTGATTTGAAAAACCCAATCATTCCTGCATCAGGCTGCTTCGGTTTTGGAAAAGA
ATTTTCACGTTTTTATGATTTGTCTTGTCTTGGAGCTATCATGATTAAGGCTACGACAAAGGAGCCGCGCTTTGGGAATC
CGACGCCGCGGGTAGCTGAGACTGGTGCTGGAATGCTCAATGCGATCGGTCTCCAAAATCCGGGGCTGGATAGTGTGTTG
CATCATGAGCTGCCGTGGCTTGAGCAGTTTGATACACCGATCATTGCCAATGTCGCAGGTTCTCAAGTCGATGATTATGT
TGAAGTCGCAGAACATATCAGCAAAGCGCCTAATGTTCATGCTCTTGAATTGAATATTTCCTGCCCGAATGTGAAAACAG
GCGGAATCGCTTTTGGCACGAATCCTGAAATGGCTGCCGATTTGACAAAAGCGGTGAAAGAGGTTTCGGATGTACCCGTT
TATGTGAAGCTATCCCCGAACGTGGCTAATATCACAGAAATTGCATTAGCGATCGAGGAAGCGGGAGCGGACGGTCTTAC
GATGATCAACACACTAATCGGCATGAGACTCGATTTAAAAACCGGCAAACCGATATTAGCGAATAAAACAGGGGGACTTT
CGGGCCCTGCTGTGAAGCCGGTTGCCATTCGCATGGTGTATGAAGTCAGCCAGATGGTCAACATCCCGATTATCGGAATG
GGAGGCGTGCAAACGGCTGAAGATGCCCTGGAATTTCTTCTCGCGGGAGCAAGCGCAGTCGCTGTCGGAACAGCAAACTT
TGTGAATCCTTTTGCATGTCCAGAGATTATTGAACAGCTCCCATCTGTTTTGCTCCAATACGGCTATCAATCAATTGAAG
AATGCATCGGAAGGAGCTGGAATCATGAAAAACAACCTGCCCATCATCGCGCTTGA

Upstream 100 bases:

>100_bases
CATGCTTCGCGTGTGTGTGCCATACAAACGAAAGTGAGACATCCTATGTAAAAGTATGTCTCGACGGGCCTGTATTTAAA
GCTCAGGAGGTGGCGCTGTA

Downstream 100 bases:

>100_bases
TTTTGCGTCAGCTGAAGAAACACTTGCGTTCTTAGCGCCTTTTCAGCAAGAACCGTTATTTGTAAAGGTTGGGATGGAGC
TTTTTTATCAAGAAGGGCCA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVL
HHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV
YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM
GGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA

Sequences:

>Translated_311_residues
MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVL
HHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV
YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM
GGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA
>Mature_311_residues
MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVL
HHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV
YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM
GGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=301, Percent_Identity=30.8970099667774, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI45006951, Length=324, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI87082059, Length=331, Percent_Identity=30.2114803625378, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787177, Length=297, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984108, Length=206, Percent_Identity=32.5242718446602, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17509475, Length=327, Percent_Identity=27.82874617737, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=313, Percent_Identity=30.3514376996805, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640763, Length=184, Percent_Identity=33.1521739130435, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18858217, Length=184, Percent_Identity=33.1521739130435, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=28.8401253918495, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=28.8401253918495, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33092; Mature: 33092

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAE
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHH
TGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVH
HCCCHHHHCCCCCCCHHHHHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCEE
ALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPVYVKLSPNVANITEIALAIEE
EEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
AGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM
CCCCHHHHHHHHHCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEC
GGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLPSVLLQYGYQSIEECIGRSW
CCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
NHEKQPAHHRA
CCCCCCCCCCC
>Mature Secondary Structure
MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAE
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHH
TGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVH
HCCCHHHHCCCCCCCHHHHHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCEE
ALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPVYVKLSPNVANITEIALAIEE
EEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
AGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM
CCCCHHHHHHHHHCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEC
GGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLPSVLLQYGYQSIEECIGRSW
CCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
NHEKQPAHHRA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA