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The map label for this gene is pycA

Identifier: 16078550

GI number: 16078550

Start: 1554185

End: 1557631

Strand: Direct

Name: pycA

Synonym: BSU14860

Alternate gene names: 16078550

Gene position: 1554185-1557631 (Clockwise)

Preceding gene: 16078549

Following gene: 16078552

Centisome position: 36.87

GC content: 45.2

Gene sequence:

>3447_bases
TTGTCTCAGCAATCGATACAAAAAGTATTAGTAGCAAACAGGGGAGAAATTGCAATCCGAATATTCCGGGCGTGTACCGA
GTTGAATATTCGTACAGTTGCGGTCTATTCAAAAGAAGATTCCGGTTCCTACCATCGGTACAAAGCGGATGAAGCATACT
TGGTCGGTGAAGGGAAAAAACCGATTGATGCTTACCTGGATATTGAAGGTATCATTGATATTGCGAAAAGAAACAAAGTC
GATGCAATTCATCCGGGATACGGTTTCTTATCTGAAAATATTCATTTTGCGAGACGATGTGAAGAAGAAGGCATCGTATT
CATAGGGCCAAAATCCGAGCATCTCGATATGTTTGGTGACAAGGTAAAAGCGCGTGAGCAGGCAGAAAAAGCGGGAATCC
CCGTGATTCCGGGAAGCGACGGTCCTGCCGAAACGCTTGAAGCCGTCGAACAATTTGGACAAGCTAACGGTTATCCGATC
ATCATTAAAGCCTCGCTTGGCGGCGGCGGCCGCGGTATGCGGATTGTCAGATCTGAAAGTGAAGTTAAAGAAGCATATGA
GCGTGCTAAATCAGAGGCGAAAGCAGCCTTTGGCAATGATGAAGTTTATGTAGAAAAATTAATTGAGAATCCGAAACATA
TTGAGGTTCAGGTCATTGGAGACAAGCAGGGCAATGTCGTCCATCTTTTTGAGAGGGATTGCTCCGTTCAAAGACGCCAT
CAAAAAGTCATTGAAGTGGCGCCGAGTGTCTCGCTGTCACCTGAATTAAGGGACCAAATTTGTGAGGCTGCAGTTGCGCT
TGCCAAAAATGTAAACTATATAAATGCGGGGACGGTCGAATTCCTTGTTGCAAACAACGAGTTCTACTTTATTGAAGTAA
ATCCTCGCGTACAAGTTGAACACACGATAACAGAAATGATTACTGGTGTCGATATTGTTCAAACTCAGATCCTTGTTGCC
CAAGGGCACAGCCTTCACAGCAAAAAAGTAAATATTCCTGAGCAAAAGGACATTTTTACAATCGGCTATGCCATTCAGTC
ACGGGTTACGACTGAGGATCCGCAAAATGATTTCATGCCTGATACAGGAAAAATCATGGCTTACCGCTCAGGCGGCGGTT
TTGGTGTCCGTCTTGATACCGGAAACAGCTTCCAGGGCGCCGTGATCACACCATACTATGATTCACTTCTCGTTAAGCTT
TCAACTTGGGCTTTAACGTTTGAACAGGCAGCTGCCAAAATGGTGCGAAACCTTCAGGAGTTTAGAATCAGAGGCATAAA
AACGAACATTCCGTTCCTTGAGAACGTTGCAAAGCATGAGAAGTTCCTGACAGGGCAATATGATACATCTTTCATTGATA
CAACGCCTGAATTATTTAATTTCCCTAAACAAAAAGACCGCGGAACGAAAATGCTCACTTACATCGGCAATGTGACAGTG
AACGGCTTCCCTGGAATCGGGAAAAAAGAAAAACCGGCGTTTGACAAACCGTTAGGCGTAAAGGTAGACGTTGATCAGCA
GCCTGCCAGAGGAACAAAGCAAATTCTCGATGAAAAAGGTGCAGAAGGGCTTGCAAATTGGGTTAAGGAGCAGAAATCTG
TCCTTTTAACTGATACGACATTCAGGGATGCCCACCAATCGTTATTGGCAACTAGAATCAGATCGCATGATTTGAAAAAA
ATCGCAAATCCGACGGCTGCGTTATGGCCTGAACTATTCAGTATGGAAATGTGGGGAGGCGCGACCTTCGATGTAGCCTA
CCGATTCCTGAAAGAAGATCCGTGGAAACGTTTGGAAGATCTTCGCAAAGAAGTGCCGAATACCTTATTCCAGATGTTGC
TTCGCTCATCAAATGCGGTCGGCTATACGAATTATCCGGACAATGTGATTAAAGAATTTGTGAAGCAATCAGCTCAATCC
GGTATTGATGTGTTTCGTATTTTCGACAGCTTAAACTGGGTAAAAGGGATGACGTTAGCCATTGATGCTGTTAGGGATAC
CGGCAAAGTGGCAGAAGCTGCGATTTGTTATACGGGAGATATCCTTGACAAGAACCGGACGAAGTACGACCTTGCATATT
ATACATCGATGGCGAAGGAGCTTGAGGCGGCCGGAGCCCATATTCTCGGGATTAAAGATATGGCAGGGCTGTTAAAACCG
CAGGCTGCATATGAGCTCGTTTCTGCGTTGAAAGAAACGATCGACATTCCGGTTCACCTTCATACGCATGATACGAGCGG
AAACGGTATTTATATGTATGCGAAAGCTGTTGAAGCCGGCGTTGATATCATAGACGTGGCGGTCAGCTCAATGGCGGGAT
TAACGTCACAGCCTAGCGCGAGCGGATTTTATCATGCGATGGAAGGCAACGACCGCCGTCCGGAAATGAATGTCCAAGGC
GTTGAATTGCTGTCCCAATATTGGGAGTCGGTGCGTAAATATTATAGTGAATTTGAAAGCGGAATGAAGTCTCCGCATAC
TGAAATTTATGAACACGAAATGCCAGGGGGCCAATACAGCAACCTGCAGCAGCAAGCCAAGGGAGTAGGCCTTGGCGACC
GCTGGAACGAAGTCAAGGAAATGTACAGACGCGTGAACGATATGTTCGGTGACATCGTCAAGGTAACGCCTTCCTCAAAA
GTAGTCGGAGATATGGCACTCTACATGGTGCAAAACAATCTGACTGAAAAAGACGTTTACGAAAAAGGTGAATCTTTAGA
TTTCCCTGATTCTGTCGTGGAGCTTTTTAAAGGAAATATCGGCCAGCCTCATGGCGGATTCCCAGAAAAACTGCAAAAGC
TGATCTTAAAAGGGCAGGAGCCGATTACAGTCAGACCGGGCGAACTGCTTGAGCCGGTGTCATTTGAAGCGATCAAACAG
GAATTTAAAGAGCAGCATAACTTGGAAATTTCAGATCAGGATGCTGTGGCATATGCCCTTTATCCTAAAGTCTTCACTGA
TTATGTGAAAACGACAGAAAGCTATGGAGACATCTCGGTATTAGATACACCGACATTCTTCTACGGTATGACATTAGGTG
AAGAGATAGAAGTTGAAATTGAGCGCGGCAAAACGCTGATCGTTAAGCTGATTTCAATCGGTGAGCCTCAGCCTGATGCC
ACCCGCGTCGTTTATTTCGAACTCAACGGGCAGCCGCGTGAAGTAGTCATTAAAGATGAAAGCATTAAGTCTTCCGTTCA
GGAAAGGCTGAAAGCAGACCGGACAAATCCAAGCCACATCGCAGCTTCCATGCCTGGAACAGTTATTAAGGTATTGGCTG
AAGCAGGCACAAAAGTCAATAAAGGTGATCATTTGATGATTAATGAAGCGATGAAAATGGAAACAACGGTTCAGGCGCCT
TTCTCAGGAACAATCAAGCAGGTTCATGTGAAAAATGGTGAGCCGATCCAAACGGGAGATCTGCTCCTTGAAATTGAAAA
AGCATAA

Upstream 100 bases:

>100_bases
AGCTCAAAAAAACTGTTTATCTGTAAAAAACAAGTGTGTACAGGGGAAGGATATTCCGCTATGATAGATTATATTCCATT
CGGGTAAGGGGGAGAAAAGT

Downstream 100 bases:

>100_bases
AAAACAAAGAGTGTATATCAATGATATACACTCTTGTTTTTTATATAGAAAATGTGGAGTGAAACAGATGGTTAGAAGAG
ATATAAGGGGACTTCAGAGA

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC

Number of amino acids: Translated: 1148; Mature: 1147

Protein sequence:

>1148_residues
MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSYHRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKV
DAIHPGYGFLSENIHFARRCEEEGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI
IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQVIGDKQGNVVHLFERDCSVQRRH
QKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINAGTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVA
QGHSLHSKKVNIPEQKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPYYDSLLVKL
STWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTSFIDTTPELFNFPKQKDRGTKMLTYIGNVTV
NGFPGIGKKEKPAFDKPLGVKVDVDQQPARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKK
IANPTAALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTNYPDNVIKEFVKQSAQS
GIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDILDKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKP
QAAYELVSALKETIDIPVHLHTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNVQG
VELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWNEVKEMYRRVNDMFGDIVKVTPSSK
VVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVELFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQ
EFKEQHNLEISDQDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKLISIGEPQPDA
TRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTVIKVLAEAGTKVNKGDHLMINEAMKMETTVQAP
FSGTIKQVHVKNGEPIQTGDLLLEIEKA

Sequences:

>Translated_1148_residues
MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSYHRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKV
DAIHPGYGFLSENIHFARRCEEEGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI
IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQVIGDKQGNVVHLFERDCSVQRRH
QKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINAGTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVA
QGHSLHSKKVNIPEQKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPYYDSLLVKL
STWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTSFIDTTPELFNFPKQKDRGTKMLTYIGNVTV
NGFPGIGKKEKPAFDKPLGVKVDVDQQPARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKK
IANPTAALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTNYPDNVIKEFVKQSAQS
GIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDILDKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKP
QAAYELVSALKETIDIPVHLHTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNVQG
VELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWNEVKEMYRRVNDMFGDIVKVTPSSK
VVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVELFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQ
EFKEQHNLEISDQDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKLISIGEPQPDA
TRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTVIKVLAEAGTKVNKGDHLMINEAMKMETTVQAP
FSGTIKQVHVKNGEPIQTGDLLLEIEKA
>Mature_1147_residues
SQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSYHRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVD
AIHPGYGFLSENIHFARRCEEEGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPII
IKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQVIGDKQGNVVHLFERDCSVQRRHQ
KVIEVAPSVSLSPELRDQICEAAVALAKNVNYINAGTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQ
GHSLHSKKVNIPEQKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPYYDSLLVKLS
TWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTSFIDTTPELFNFPKQKDRGTKMLTYIGNVTVN
GFPGIGKKEKPAFDKPLGVKVDVDQQPARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKI
ANPTAALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTNYPDNVIKEFVKQSAQSG
IDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDILDKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQ
AAYELVSALKETIDIPVHLHTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNVQGV
ELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWNEVKEMYRRVNDMFGDIVKVTPSSKV
VGDMALYMVQNNLTEKDVYEKGESLDFPDSVVELFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQE
FKEQHNLEISDQDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKLISIGEPQPDAT
RVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTVIKVLAEAGTKVNKGDHLMINEAMKMETTVQAPF
SGTIKQVHVKNGEPIQTGDLLLEIEKA

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI106049528, Length=1151, Percent_Identity=51.3466550825369, Blast_Score=1167, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1151, Percent_Identity=51.3466550825369, Blast_Score=1167, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1151, Percent_Identity=51.3466550825369, Blast_Score=1167, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=452, Percent_Identity=44.9115044247788, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI65506442, Length=462, Percent_Identity=43.5064935064935, Blast_Score=369, Evalue=1e-101,
Organism=Homo sapiens, GI295821183, Length=462, Percent_Identity=43.5064935064935, Blast_Score=369, Evalue=1e-101,
Organism=Homo sapiens, GI189095269, Length=460, Percent_Identity=43.695652173913, Blast_Score=368, Evalue=1e-101,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=32.3586744639376, Blast_Score=245, Evalue=2e-64,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=32.3586744639376, Blast_Score=245, Evalue=2e-64,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=32.3586744639376, Blast_Score=245, Evalue=2e-64,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=32.3586744639376, Blast_Score=245, Evalue=2e-64,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=32.3586744639376, Blast_Score=245, Evalue=2e-64,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=31.3111545988258, Blast_Score=237, Evalue=4e-62,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=46.5478841870824, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1786216, Length=321, Percent_Identity=23.6760124610592, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562816, Length=1148, Percent_Identity=49.3031358885017, Blast_Score=1143, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17567343, Length=467, Percent_Identity=43.8972162740899, Blast_Score=355, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI71987519, Length=461, Percent_Identity=44.2516268980477, Blast_Score=350, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=498, Percent_Identity=30.3212851405622, Blast_Score=220, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=439, Percent_Identity=30.2961275626424, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=439, Percent_Identity=30.2961275626424, Blast_Score=210, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1156, Percent_Identity=49.4809688581315, Blast_Score=1105, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1155, Percent_Identity=49.7835497835498, Blast_Score=1101, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=38.2222222222222, Blast_Score=299, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323863, Length=438, Percent_Identity=32.648401826484, Blast_Score=224, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=512, Percent_Identity=29.4921875, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322331, Length=302, Percent_Identity=22.1854304635762, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652212, Length=1153, Percent_Identity=51.7779705117086, Blast_Score=1184, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1153, Percent_Identity=51.7779705117086, Blast_Score=1184, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1153, Percent_Identity=51.7779705117086, Blast_Score=1184, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1153, Percent_Identity=51.7779705117086, Blast_Score=1184, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1153, Percent_Identity=51.7779705117086, Blast_Score=1184, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1169, Percent_Identity=51.1548331907613, Blast_Score=1176, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1169, Percent_Identity=51.1548331907613, Blast_Score=1176, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1169, Percent_Identity=51.1548331907613, Blast_Score=1176, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1169, Percent_Identity=51.1548331907613, Blast_Score=1176, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1169, Percent_Identity=51.1548331907613, Blast_Score=1176, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=453, Percent_Identity=42.8256070640177, Blast_Score=368, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=412, Percent_Identity=42.2330097087379, Blast_Score=327, Evalue=4e-89,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=32.6043737574553, Blast_Score=243, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=32.6043737574553, Blast_Score=243, Evalue=7e-64,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=32.6043737574553, Blast_Score=243, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=32.6043737574553, Blast_Score=243, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYC_BACSU (Q9KWU4)

Other databases:

- EMBL:   AL009126
- EMBL:   Z97025
- EMBL:   Z98682
- PIR:   F69685
- RefSeq:   NP_389369.1
- ProteinModelPortal:   Q9KWU4
- SMR:   Q9KWU4
- EnsemblBacteria:   EBBACT00000002339
- GeneID:   935920
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU14860
- NMPDR:   fig|224308.1.peg.1488
- GenoList:   BSU14860
- GeneTree:   EBGT00050000001329
- HOGENOM:   HBG717218
- OMA:   DIVQSQI
- PhylomeDB:   Q9KWU4
- ProtClustDB:   PRK12999
- BioCyc:   BSUB:BSU14860-MONOMER
- BRENDA:   6.4.1.1
- GO:   GO:0005737
- GO:   GO:0006094
- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053
- Gene3D:   G3DSA:3.20.20.70
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- PIRSF:   PIRSF001594
- SMART:   SM00878
- TIGRFAMs:   TIGR01235

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA; SSF51230 Hybrid_motif; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.4.1.1

Molecular weight: Translated: 127938; Mature: 127807

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL; PS00866 CPSASE_1; PS00867 CPSASE_2; PS50991 PYR_CT

Important sites: ACT_SITE 242-242 BINDING 121-121 BINDING 205-205 BINDING 240-240 BINDING 615-615 BINDING 876-876

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSYHRYKADEAYLVGEGKK
CCHHHHHHHHHCCCCCHHHHEEHHHHHCCEEEEEEEECCCCCCEEEEECCCEEEEECCCC
PIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEEEGIVFIGPKSEHLDMFGD
CCHHHEEHHHHHHHHHCCCCCEECCCCCHHHCCCHHHHHHCCCCEEEECCCCHHHHHHHH
KVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPIIIKASLGGGGRGMRIVRSES
HHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECHH
EVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQVIGDKQGNVVHLFERDCSVQRRH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHH
QKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINAGTVEFLVANNEFYFIEVNPRVQVE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCEEEEEEECCCEEEH
HTITEMITGVDIVQTQILVAQGHSLHSKKVNIPEQKDIFTIGYAIQSRVTTEDPQNDFMP
HHHHHHHCCHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCC
DTGKIMAYRSGGGFGVRLDTGNSFQGAVITPYYDSLLVKLSTWALTFEQAAAKMVRNLQE
CCCCEEEEECCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRIRGIKTNIPFLENVAKHEKFLTGQYDTSFIDTTPELFNFPKQKDRGTKMLTYIGNVTV
HHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCEEE
NGFPGIGKKEKPAFDKPLGVKVDVDQQPARGTKQILDEKGAEGLANWVKEQKSVLLTDTT
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCEEEEECH
FRDAHQSLLATRIRSHDLKKIANPTAALWPELFSMEMWGGATFDVAYRFLKEDPWKRLED
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
LRKEVPNTLFQMLLRSSNAVGYTNYPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IDAVRDTGKVAEAAICYTGDILDKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKP
EEHHHCCCCHHHEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCC
QAAYELVSALKETIDIPVHLHTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSA
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCCCC
SGFYHAMEGNDRRPEMNVQGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYS
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHH
NLQQQAKGVGLGDRWNEVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVY
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHHH
EKGESLDFPDSVVELFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQ
HCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHCCCCCHHHHHH
EFKEQHNLEISDQDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEI
HHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCHHEEECCCCCEEEEEE
ERGKTLIVKLISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHI
ECCCEEEEEHHHCCCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCHHHE
AASMPGTVIKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGD
ECCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHEECCCCCCCEEEEEECCCCCCCCCC
LLLEIEKA
EEEEEECC
>Mature Secondary Structure 
SQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSYHRYKADEAYLVGEGKK
CHHHHHHHHHCCCCCHHHHEEHHHHHCCEEEEEEEECCCCCCEEEEECCCEEEEECCCC
PIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEEEGIVFIGPKSEHLDMFGD
CCHHHEEHHHHHHHHHCCCCCEECCCCCHHHCCCHHHHHHCCCCEEEECCCCHHHHHHHH
KVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPIIIKASLGGGGRGMRIVRSES
HHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECHH
EVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQVIGDKQGNVVHLFERDCSVQRRH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHH
QKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINAGTVEFLVANNEFYFIEVNPRVQVE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCEEEEEEECCCEEEH
HTITEMITGVDIVQTQILVAQGHSLHSKKVNIPEQKDIFTIGYAIQSRVTTEDPQNDFMP
HHHHHHHCCHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCC
DTGKIMAYRSGGGFGVRLDTGNSFQGAVITPYYDSLLVKLSTWALTFEQAAAKMVRNLQE
CCCCEEEEECCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRIRGIKTNIPFLENVAKHEKFLTGQYDTSFIDTTPELFNFPKQKDRGTKMLTYIGNVTV
HHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCEEE
NGFPGIGKKEKPAFDKPLGVKVDVDQQPARGTKQILDEKGAEGLANWVKEQKSVLLTDTT
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCEEEEECH
FRDAHQSLLATRIRSHDLKKIANPTAALWPELFSMEMWGGATFDVAYRFLKEDPWKRLED
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
LRKEVPNTLFQMLLRSSNAVGYTNYPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IDAVRDTGKVAEAAICYTGDILDKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKP
EEHHHCCCCHHHEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCC
QAAYELVSALKETIDIPVHLHTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSA
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCCCC
SGFYHAMEGNDRRPEMNVQGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYS
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHH
NLQQQAKGVGLGDRWNEVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVY
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHHH
EKGESLDFPDSVVELFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQ
HCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHCCCCCHHHHHH
EFKEQHNLEISDQDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEI
HHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCHHEEECCCCCEEEEEE
ERGKTLIVKLISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHI
ECCCEEEEEHHHCCCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCHHHE
AASMPGTVIKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGD
ECCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHEECCCCCCCEEEEEECCCCCCCCCC
LLLEIEKA
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377