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The map label for this gene is speA

Identifier: 16078527

GI number: 16078527

Start: 1534279

End: 1535751

Strand: Reverse

Name: speA

Synonym: BSU14630

Alternate gene names: 16078527

Gene position: 1535751-1534279 (Counterclockwise)

Preceding gene: 16078529

Following gene: 16078526

Centisome position: 36.43

GC content: 43.45

Gene sequence:

>1473_bases
TTGTCGCAACATGAAACACCCTTATACACAGGACTGAAAAAGCATGCAAGCAGACAGCCTGTTCAATTCCACATTCCCGG
CCATAAAAAAGGGGCAGGAATGGACCCAGAATTCAGACAATTTATCGGTGAAAACGCGTTAAGCATAGATTTGATTAATA
TTGAACCATTAGACGATCTGCACGCGCCAAAAGGCATTATTAAACAAGCACAAGATCTGGCTGCTGAAGCATTTGGAGCG
GATCATACATTTTTTTCTGTTCAAGGAACAAGCGGCGCCATTATGACAATGGTAATGGCTGTTTGCGGACCTGGTGATAA
AATTATTATTCCAAGAAATGTTCATAAATCAATTATGACAGCTATTGTATTTTCCGGAGCGGTTCCAATTTTTATTCATC
CTGAAATTGACAATGAATTGGGCATCTCCCACGGAATTACACTTGAATCTGCTAAACGGGCGCTTACCGAGCATCCGGAT
GCAAAAGGGCTTCTCGTCATCAACCCGACATATTTCGGTGTTGCAGCCGACTTAAAAAGCATCGTAGAACTCGCTCATTC
GTTTGATGTGCCAGTGCTTGTGGATGAAGCACACGGCGTTCACATTCATTTTCACGACGAATTGCCGCTATCGGCTATGC
AGGCAGGAGCGGACATAGCAGCGACAAGTGTACACAAGCTGGGCGGATCACTGACACAAAGCTCTATTTTAAACATGAGA
GAAGGCCTTGTATCTAAAGACAGAGTGCAATCCATCCTGAGCATGCTGACAACTACGTCAACTTCTTACTTGCTTCTCGC
TTCTTTGGATGTTGCCAGAAAACGCCTTGCAACAGAAGGCCGCCAGCTTGCTGAGGAAACACTCAAGCTTGCCAATCAGA
CGAGAGATCGCCTCAATCAGATTGAAGGCATTTATTGTGTCGGTTCTGAGATTCTTGGGTCGAAAGCAGCTTACAGCTAT
GATCCGACAAAATTGATTATCTCTGTGAAAAGTCTTGGCCTGACAGGACATGACGTGGAAAAATGGCTTCGTGAATCCTT
TAATATTGAGGTGGAGCTTTCTGATCTGTACAATATTTTGTGTATTTTCACTCCTGGTGACAGCCAAAATGATGCAGACC
GGCTTGTAGAGGCTTTAACTGAGATCGCACAGCAAATGTCAGAACAAGATGTAACACATCAGCAAACTGAGGTTCTGCTT
CCAGAAATACCTTTATTGGCAATGACTCCGCGTGATGCTTTCTATGCAAATACGGAAGTCATCCCATTAAAAGAAGCATC
CGGACGGATTATTGCTGAATTTGTCATGGTATATCCGCCTGGTATTCCAATCTTCATCCCAGGAGAAATTATTACAGAAG
AAAACATCAGCTACATTTTTAAAAACCTTGACGCAGGCCTCCCTGTTCAAGGACCTGAGGACTCGACTTTACATATGATC
CGGGTCATCAAAGAACAAAAAGCAATTCAATAA

Upstream 100 bases:

>100_bases
CATAATATAATTCATTTGTTTTACGTCTAAAAAACGGTTGAGAAACTGATTTTAATACACACTATTATGCATAGGTATGA
TTACAAAGGTGGGAAAACAA

Downstream 100 bases:

>100_bases
AAAATAAAAAGCATGCGGCTTTAAGCCGCATGCTTTTTTTTACTCTTCATCAACAGGACATTGACATTGTCCGCAGCAAG
TTCCATATAATGTTGTCACT

Product: arginine decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGENALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGA
DHTFFSVQGTSGAIMTMVMAVCGPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD
AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGADIAATSVHKLGGSLTQSSILNMR
EGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRLATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSY
DPTKLIISVKSLGLTGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVTHQQTEVLL
PEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEIITEENISYIFKNLDAGLPVQGPEDSTLHMI
RVIKEQKAIQ

Sequences:

>Translated_490_residues
MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGENALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGA
DHTFFSVQGTSGAIMTMVMAVCGPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD
AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGADIAATSVHKLGGSLTQSSILNMR
EGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRLATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSY
DPTKLIISVKSLGLTGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVTHQQTEVLL
PEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEIITEENISYIFKNLDAGLPVQGPEDSTLHMI
RVIKEQKAIQ
>Mature_489_residues
SQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGENALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGAD
HTFFSVQGTSGAIMTMVMAVCGPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPDA
KGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGADIAATSVHKLGGSLTQSSILNMRE
GLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRLATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYD
PTKLIISVKSLGLTGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVTHQQTEVLLP
EIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEIITEENISYIFKNLDAGLPVQGPEDSTLHMIR
VIKEQKAIQ

Specific function: Catalyzes the formation of agmatine from arginine

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family

Homologues:

Organism=Escherichia coli, GI1786384, Length=545, Percent_Identity=24.7706422018349, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790573, Length=546, Percent_Identity=25.2747252747253, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87082193, Length=566, Percent_Identity=23.8515901060071, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI221142684, Length=380, Percent_Identity=26.5789473684211, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786909, Length=600, Percent_Identity=24.3333333333333, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_BACSU (P21885)

Other databases:

- EMBL:   X58433
- EMBL:   AF012285
- EMBL:   AL009126
- EMBL:   M57435
- PIR:   A54546
- RefSeq:   NP_389346.1
- ProteinModelPortal:   P21885
- SMR:   P21885
- EnsemblBacteria:   EBBACT00000000428
- GeneID:   936002
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU14630
- NMPDR:   fig|224308.1.peg.1465
- GenoList:   BSU14630
- GeneTree:   EBGT00050000002042
- HOGENOM:   HBG634412
- OMA:   VCVVSVH
- PhylomeDB:   P21885
- ProtClustDB:   CLSK873379
- BioCyc:   BSUB:BSU14630-MONOMER
- BRENDA:   4.1.1.19
- GO:   GO:0005737
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.90.100.10
- Gene3D:   G3DSA:3.40.640.10

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; SSF55904 Decarbxylse_C; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.19

Molecular weight: Translated: 53584; Mature: 53453

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGENALSIDLINIEPLDDL
CCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHH
HAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVCGPGDKIIIPRNVHKSIMT
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHH
AIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPDAKGLLVINPTYFGVAADLKS
HHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGADIAATSVHKLGGSLTQSSILNMR
HHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
EGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRLATEGRQLAEETLKLANQTRDRLNQ
HCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGLTGHDVEKWLRESFNIEVELSDLYNIL
CCCEEEECHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCEEEE
CIFTPGDSQNDADRLVEALTEIAQQMSEQDVTHQQTEVLLPEIPLLAMTPRDAFYANTEV
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IPLKEASGRIIAEFVMVYPPGIPIFIPGEIITEENISYIFKNLDAGLPVQGPEDSTLHMI
EEECCCCCCEEEHHHHHCCCCCCEEECCCEECCCHHHHHHHHCCCCCCCCCCCCCHHHHH
RVIKEQKAIQ
HHHHHHHCCC
>Mature Secondary Structure 
SQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGENALSIDLINIEPLDDL
CCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHH
HAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVCGPGDKIIIPRNVHKSIMT
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHH
AIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPDAKGLLVINPTYFGVAADLKS
HHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGADIAATSVHKLGGSLTQSSILNMR
HHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
EGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRLATEGRQLAEETLKLANQTRDRLNQ
HCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGLTGHDVEKWLRESFNIEVELSDLYNIL
CCCEEEECHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCEEEE
CIFTPGDSQNDADRLVEALTEIAQQMSEQDVTHQQTEVLLPEIPLLAMTPRDAFYANTEV
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IPLKEASGRIIAEFVMVYPPGIPIFIPGEIITEENISYIFKNLDAGLPVQGPEDSTLHMI
EEECCCCCCEEEHHHHHCCCCCCEEECCCEECCCHHHHHHHHCCCCCCCCCCCCCHHHHH
RVIKEQKAIQ
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969500; 9384377; 1697575; 1936936