Click here to switch to the map view.

The map label for this gene is ykrL

Identifier: 16078413

GI number: 16078413

Start: 1414997

End: 1415893

Strand: Direct

Name: ykrL

Synonym: BSU13490

Alternate gene names: 16078413

Gene position: 1414997-1415893 (Clockwise)

Preceding gene: 16078410

Following gene: 16078414

Centisome position: 33.57

GC content: 45.93

Gene sequence:

>897_bases
ATGGCGAAAAGAATTTTTCTGTTTATTCTAACGAATATTTTGGTGCTTACAACAATCGGGATCGTTTTGTCTGTTTTAAG
CTCTGTTACAGGAGTCGGGACGTACTTTACAGCTGATGGCGGTATCGATCCAATGGCGCTTCTTGTGTTCAGTTTAGTCG
TTGGATTTGTCGGTTCCTTTACGTCTCTTGCGATATCCAGATGGATGGCAAAGACGATGATGGGCGTCAGAGTGCTGAAT
CCGAAAAAACACTCGCTCAGCTATGAGGAACAGCAATTGGTTGATCGTGTTCACAGATTAAGCCGCTCTGCCGGTTTAAC
GAAAATGCCGGAAGTCGGGATTTACCGTTCACCTGAAGTAAACGCGTTTGCGACTGGACCGTCAAAACGCCGTTCACTTG
TCGCAGTATCGTCAGGGCTGCTGGAGCAGATGGATGACGCAGCAGTTGAAGGTGTGCTTGCCCACGAGGTCGCGCATATC
ACAAATGGTGATATGGTAACAATGACGCTTTTACAAGGTATCGTTAATACCTTTGTCGTCTTTTTATCGCGTATCGCCGC
TTGGATAGCAAGCCGTTTTGTCAAAGAAGATCTAGCGCCGATCGTTCATTTTATTGCAATGATTATTTTTCAGATTGTCT
TTTCGATACTTGGCAGCCTGGTTGTGTTTGCGTATTCACGCCATCGTGAATTCCATGCTGACAGGGGAGGAGCGGATCTT
GCCGGCAAGGACAAGATGATTCATGCGCTGCGGACGCTTAAAAGCTATTCTTCCCGGATTTTGGAAGACGATCAGACAGC
TGTCCAAACGTTAAAGATTAATGGCAAGAAGCGCTCTTCACTTTTCTCTACTCATCCTGATTTAGATGAGCGAATCAGAC
GGCTGGAAGCTAAATAA

Upstream 100 bases:

>100_bases
ATTACATTAACATCATACGTCGAATTCCTTGCATTTTCAAATGGATGTTTTATAATTTAAATATACGGGTTCTTTTGAAC
TTAAAATAACGGAGGTTGTT

Downstream 100 bases:

>100_bases
TACAAACACATTGTTCCTCTGAGAGAATTCTCAGAGGTTTTTTATTTTATCCATTGACTAAAATCATAAAAAAATAAGCA
AGTTAAGAAAATGTTTCGTA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLN
PKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI
TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADL
AGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK

Sequences:

>Translated_298_residues
MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLN
PKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI
TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADL
AGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK
>Mature_297_residues
AKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNP
KKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHIT
NGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADLA
GKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=303, Percent_Identity=44.2244224422442, Blast_Score=237, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_BACSU (O31657)

Other databases:

- EMBL:   AL009126
- PIR:   G69862
- RefSeq:   NP_389232.1
- ProteinModelPortal:   O31657
- SMR:   O31657
- MEROPS:   M48.002
- EnsemblBacteria:   EBBACT00000001682
- GeneID:   939359
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU13490
- NMPDR:   fig|224308.1.peg.1351
- GenoList:   BSU13490
- GeneTree:   EBGT00050000002110
- HOGENOM:   HBG739460
- OMA:   KMISALE
- PhylomeDB:   O31657
- ProtClustDB:   PRK05457
- BioCyc:   BSUB:BSU13490-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32866; Mature: 32735

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 156-156

Signals:

None

Transmembrane regions:

HASH(0xb4eacc0)-; HASH(0xeb7e0e0)-; HASH(0xe29c530)-; HASH(0xe7b5fcc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
TSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEV
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHITNGDMVTMTLLQGIVNTFVV
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCH
>Mature Secondary Structure 
AKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
TSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEV
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHITNGDMVTMTLLQGIVNTFVV
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377