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The map label for this gene is fabF

Identifier: 16078199

GI number: 16078199

Start: 1209183

End: 1210424

Strand: Direct

Name: fabF

Synonym: BSU11340

Alternate gene names: 16078199

Gene position: 1209183-1210424 (Clockwise)

Preceding gene: 16078198

Following gene: 16078200

Centisome position: 28.68

GC content: 46.7

Gene sequence:

>1242_bases
ATGACTAAAAAAAGAGTAGTTGTTACAGGACTTGGAGCATTATCTCCACTTGGCAACGACGTCGATACAAGTTGGAATAA
CGCAATCAACGGTGTGTCCGGAATCGGTCCGATCACTCGTGTTGACGCTGAAGAATATCCGGCAAAAGTTGCCGCTGAAT
TAAAAGATTTTAATGTTGAAGATTATATGGATAAAAAAGAAGCCAGAAAAATGGACCGCTTTACACAATATGCGGTTGTG
GCTGCGAAAATGGCGGTTGAAGATGCAGATCTTAACATTACCGATGAGATCGCGCCGAGAGTCGGTGTTTGGGTAGGCTC
CGGTATCGGAGGACTTGAAACACTAGAGTCTCAATTTGAAATCTTCTTAACAAAAGGCCCAAGACGGGTAAGCCCGTTTT
TCGTGCCAATGATGATTCCTGACATGGCGACAGGCCAGATTTCTATTGCATTAGGAGCAAAAGGGGTGAACTCTTGTACG
GTTACAGCATGTGCTACAGGAACGAACTCCATCGGTGACGCGTTTAAGGTTATTCAGCGCGGTGATGCAGACGTGATGGT
CACAGGCGGAACAGAAGCGCCGCTGACAAGAATGTCATTCGCCGGCTTTAGTGCCAACAAAGCGCTGTCTACTAATCCAG
ATCCGAAAACAGCGAGCCGCCCGTTTGATAAAAACCGTGATGGCTTTGTCATGGGGGAAGGTGCAGGGATTATCGTTCTT
GAAGAACTTGAGCATGCCCTGGCCCGCGGCGCTAAAATTTACGGAGAAATTGTCGGCTACGGCTCAACCGGAGACGCTTA
TCATATCACAGCGCCGGCCCAAGACGGTGAAGGCGGAGCGAGAGCGATGCAAGAAGCCATTAAAGATGCAGGCATTGCAC
CTGAAGAAATTGATTACATCAATGCTCACGGGACAAGCACGTATTACAACGACAAATACGAAACAATGGCGATTAAGACC
GTTTTTGGCGAGCATGCGCATAAACTTGCGGTAAGCTCTACAAAATCGATGACAGGCCACCTCTTAGGAGCAGCCGGCGG
TATTGAAGCCATTTTCTCTATCCTGGCCATTAAAGAAGGCGTGATTCCGCCGACAATCAATATTCAAACACCTGACGAAG
AATGTGATTTGGATTATGTGCCTGATGAAGCCCGCAGACAGGAACTTAATTATGTTCTCAGCAACTCATTAGGATTCGGC
GGACACAACGCAACATTAATCTTTAAAAAATATCAATCATAA

Upstream 100 bases:

>100_bases
GACGGCGATGTGGTCGTTATGGTAGGGTTCGGCGGAGGACTAACATGGGGCGCCATTGCAATCCGCTGGGGCCGATAAAA
AAAGGTGAGGTGCACACAAG

Downstream 100 bases:

>100_bases
TCAAGCCAAACCGGCTGCCCTTAAAGGGTAGCCGGTTTTTTTTGTGTGCATAGGATTAAAAGAGGAGGCGATCACATGAG
TGTAGAACAAACATATAGCT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVV
AAKMAVEDADLNITDEIAPRVGVWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT
VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTASRPFDKNRDGFVMGEGAGIIVL
EELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKT
VFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFG
GHNATLIFKKYQS

Sequences:

>Translated_413_residues
MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVV
AAKMAVEDADLNITDEIAPRVGVWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT
VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTASRPFDKNRDGFVMGEGAGIIVL
EELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKT
VFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFG
GHNATLIFKKYQS
>Mature_412_residues
TKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVA
AKMAVEDADLNITDEIAPRVGVWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCTV
TACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTASRPFDKNRDGFVMGEGAGIIVLE
ELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTV
FGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFGG
HNATLIFKKYQS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=48.0769230769231, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI223972627, Length=416, Percent_Identity=32.2115384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=25.1764705882353, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=54.126213592233, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=39.9521531100478, Blast_Score=254, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=36.1650485436893, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=42.7480916030534, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=28.2122905027933, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=275, Percent_Identity=29.8181818181818, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=37.6975169300226, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=46.5721040189125, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=24.8826291079812, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221330659, Length=425, Percent_Identity=24.7058823529412, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19920632, Length=425, Percent_Identity=24.7058823529412, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABF_BACSU (O34340)

Other databases:

- EMBL:   AL009126
- PIR:   G69842
- RefSeq:   NP_389016.1
- HSSP:   Q5HHA1
- ProteinModelPortal:   O34340
- SMR:   O34340
- EnsemblBacteria:   EBBACT00000003053
- GeneID:   939803
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11340
- NMPDR:   fig|224308.1.peg.1135
- GenoList:   BSU11340
- GeneTree:   EBGT00050000000384
- HOGENOM:   HBG757733
- OMA:   NNIDEYL
- PhylomeDB:   O34340
- ProtClustDB:   PRK07314
- BioCyc:   BSUB:BSU11340-MONOMER
- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR11712
- PIRSF:   PIRSF000447
- TIGRFAMs:   TIGR03150

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; SSF53901 Thiolase-like

EC number: =2.3.1.179

Molecular weight: Translated: 44005; Mature: 43874

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: ACT_SITE 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVE
CCCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHCCCHH
DYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVGVWVGSGIGGLETLESQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHHHHHCCEE
IFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCTVTACATGTNSIGDAFKVIQR
EEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHC
GDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTASRPFDKNRDGFVMGEGAGIIVL
CCCCEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYI
HHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCEE
NAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEG
ECCCCCCEECCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHHCC
VIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFGGHNATLIFKKYQS
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVE
CCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHCCCHH
DYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVGVWVGSGIGGLETLESQFE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHHHHHCCEE
IFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCTVTACATGTNSIGDAFKVIQR
EEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHC
GDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTASRPFDKNRDGFVMGEGAGIIVL
CCCCEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYI
HHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCEE
NAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEG
ECCCCCCEECCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHHCC
VIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFGGHNATLIFKKYQS
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377