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The map label for this gene is fabHA

Identifier: 16078198

GI number: 16078198

Start: 1208222

End: 1209160

Strand: Direct

Name: fabHA

Synonym: BSU11330

Alternate gene names: 16078198

Gene position: 1208222-1209160 (Clockwise)

Preceding gene: 16078196

Following gene: 16078199

Centisome position: 28.66

GC content: 46.22

Gene sequence:

>939_bases
ATGAAAGCTGGAATACTTGGTGTTGGACGTTACATTCCTGAGAAGGTTTTAACAAATCATGATCTTGAAAAAATGGTTGA
AACTTCTGACGAGTGGATTCGTACAAGAACAGGAATAGAAGAAAGAAGAATCGCAGCAGATGATGTGTTTTCATCACATA
TGGCTGTTGCAGCAGCGAAAAATGCGCTGGAACAAGCTGAAGTGGCTGCTGAGGATCTGGATATGATCTTGGTTGCAACT
GTTACACCTGATCAGTCATTCCCTACGGTCTCTTGTATGATTCAAGAACAACTCGGCGCGAAGAAAGCGTGTGCTATGGA
TATCAGCGCGGCTTGTGCGGGCTTCATGTACGGGGTTGTAACCGGTAAACAATTTATTGAATCCGGAACCTACAAGCATG
TTCTAGTTGTTGGTGTAGAGAAGCTCTCAAGCATTACCGACTGGGAAGACCGCAATACAGCCGTTCTGTTTGGAGACGGA
GCAGGCGCTGCGGTAGTCGGGCCAGTCAGTGATGACAGAGGAATCCTTTCATTTGAACTAGGAGCCGACGGCACAGGCGG
TCAGCACTTGTATCTGAATGAAAAACGACATACAATCATGAATGGACGAGAAGTTTTCAAATTTGCAGTCCGCCAAATGG
GAGAATCATGCGTAAATGTCATTGAAAAAGCCGGACTTTCAAAAGAGGATGTCGACTTTTTGATTCCGCATCAGGCGAAC
ATCCGTATCATGGAAGCTGCTCGCGAGCGTTTAGAGCTTCCTGTCGAAAAGATGTCTAAAACTGTTCATAAATATGGAAA
TACTTCTGCCGCATCCATTCCGATCTCTCTTGTAGAAGAATTGGAAGCCGGTAAAATCAAAGACGGCGATGTGGTCGTTA
TGGTAGGGTTCGGCGGAGGACTAACATGGGGCGCCATTGCAATCCGCTGGGGCCGATAA

Upstream 100 bases:

>100_bases
GCCATGTGAAAAAAAATAGGATAGAATTAGTACCTGATACTAATAATTGATCACAACCTGATTGATCTTCTAAATTTAAG
ATATAAAGGAGTCTTCCCTA

Downstream 100 bases:

>100_bases
AAAAAGGTGAGGTGCACACAAGATGACTAAAAAAAGAGTAGTTGTTACAGGACTTGGAGCATTATCTCCACTTGGCAACG
ACGTCGATACAAGTTGGAAT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Beta-ketoacyl-ACP synthase III 1; KAS III 1; bFabH1

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVAT
VTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG
AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQAN
IRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR

Sequences:

>Translated_312_residues
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVAT
VTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG
AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQAN
IRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR
>Mature_312_residues
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVAT
VTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG
AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQAN
IRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=44.0251572327044, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH1_BACSU (O34746)

Other databases:

- EMBL:   AL009126
- PIR:   F69842
- RefSeq:   NP_389015.1
- ProteinModelPortal:   O34746
- SMR:   O34746
- EnsemblBacteria:   EBBACT00000003980
- GeneID:   936392
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11330
- NMPDR:   fig|224308.1.peg.1134
- GenoList:   BSU11330
- GeneTree:   EBGT00050000001269
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- PhylomeDB:   O34746
- ProtClustDB:   PRK09352
- BioCyc:   BSUB:BSU11330-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33732; Mature: 33732

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 237-237 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAK
CCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
NALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVV
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDGAGAAVVGPVSDDRGILSFEL
HHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEEC
GADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQAN
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCC
IRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGG
EEHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
LTWGAIAIRWGR
CCEEEEEEEECC
>Mature Secondary Structure
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAK
CCCCCCHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
NALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVV
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDGAGAAVVGPVSDDRGILSFEL
HHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEEC
GADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQAN
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCC
IRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGG
EEHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
LTWGAIAIRWGR
CCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10629181; 12737802