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The map label for this gene is sipV

Identifier: 16078113

GI number: 16078113

Start: 1122175

End: 1122681

Strand: Direct

Name: sipV

Synonym: BSU10490

Alternate gene names: 16078113

Gene position: 1122175-1122681 (Clockwise)

Preceding gene: 16078112

Following gene: 16078114

Centisome position: 26.62

GC content: 41.42

Gene sequence:

>507_bases
ATGAAAAAACGGTTTTGGTTTCTTGCCGGTGTAGTGTCCGTTGTTCTCGCCATTCAGGTTAAAAATGCTGTCTTTATTGA
TTACAAGGTAGAAGGCGTCAGTATGAACCCGACCTTCCAGGAAGGAAACGAATTGTTGGTCAATAAATTTTCGCATCGAT
TTAAAACCATCCATCGTTTTGACATCGTCCTTTTTAAAGGCCCTGATCATAAAGTGCTGATTAAACGGGTAATCGGCTTG
CCCGGTGAAACGATCAAATATAAAGATGATCAGCTGTATGTGAACGGAAAGCAGGTTGCTGAGCCATTTTTGAAGCATTT
GAAATCTGTTTCTGCCGGCAGCCATGTAACGGGTGATTTTTCTTTGAAAGATGTGACGGGAACAAGCAAGGTGCCGAAAG
GAAAATATTTTGTCGTTGGAGATAATCGCATATACAGCTTCGACAGCCGGCATTTTGGTCCGATAAGAGAAAAAAATATT
GTCGGTGTGATTTCTGATGCCGAATAA

Upstream 100 bases:

>100_bases
GTATTGGTGATCACTGTCTTATGGTATGTCGGCAAAAAGGTGGAGCGGTATCTGCATGTAAGAGCCAGTCAGCGTGAGCA
TGATGGAGGGAGACAGTAAC

Downstream 100 bases:

>100_bases
AAAGACGCTAATTGAAGAGGCGTCTTTTTGTATGCCGTTTGGAAAAATGTGTTGAAGAAAAATTTGTAAGGAGCTATAAT
CAAAATTGTTACCTGTGTAA

Product: type I signal peptidase

Products: NA

Alternate protein names: SPase I; Leader peptidase I

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGL
PGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI
VGVISDAE

Sequences:

>Translated_168_residues
MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGL
PGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI
VGVISDAE
>Mature_168_residues
MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGL
PGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI
VGVISDAE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEPV_BACSU (O07560)

Other databases:

- EMBL:   Y14081
- EMBL:   AL009126
- PIR:   A69708
- RefSeq:   NP_388930.1
- ProteinModelPortal:   O07560
- MEROPS:   S26.006
- EnsemblBacteria:   EBBACT00000001173
- GeneID:   939318
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU10490
- NMPDR:   fig|224308.1.peg.1049
- GenoList:   BSU10490
- GeneTree:   EBGT00070000031959
- HOGENOM:   HBG596607
- OMA:   ISFVESK
- PhylomeDB:   O07560
- ProtClustDB:   CLSK887016
- BioCyc:   BSUB:BSU10490-MONOMER
- BRENDA:   3.4.21.89
- GO:   GO:0006508
- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- Gene3D:   G3DSA:2.10.109.10
- PRINTS:   PR00727
- TIGRFAMs:   TIGR02227

Pfam domain/function: PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.89

Molecular weight: Translated: 18956; Mature: 18956

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS00501 SPASE_I_1; PS00760 SPASE_I_2; PS00761 SPASE_I_3

Important sites: ACT_SITE 34-34 ACT_SITE 75-75

Signals:

None

Transmembrane regions:

HASH(0xe0d4b34)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRF
CCCHHHHHHHHHHHHHHEEECCEEEEEEEEECEEECCCHHCCCHHHHHHHHHHHHEEEEE
DIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDF
EEEEEECCCCHHHHHHHHCCCCCEEEEECCEEEECCHHHHHHHHHHHHHCCCCCEEECCE
SLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNIVGVISDAE
EEEECCCCCCCCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCH
>Mature Secondary Structure
MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNELLVNKFSHRFKTIHRF
CCCHHHHHHHHHHHHHHEEECCEEEEEEEEECEEECCCHHCCCHHHHHHHHHHHHEEEEE
DIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEPFLKHLKSVSAGSHVTGDF
EEEEEECCCCHHHHHHHHCCCCCEEEEECCEEEECCHHHHHHHHHHHHHCCCCCEEECCE
SLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNIVGVISDAE
EEEECCCCCCCCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9823656