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The map label for this gene is hemE

Identifier: 16078076

GI number: 16078076

Start: 1086117

End: 1087178

Strand: Direct

Name: hemE

Synonym: BSU10120

Alternate gene names: 16078076

Gene position: 1086117-1087178 (Clockwise)

Preceding gene: 255767236

Following gene: 16078077

Centisome position: 25.76

GC content: 47.83

Gene sequence:

>1062_bases
ATGAGTAAACGAGAAACGTTTAACGAGACGTTTTTAAAAGCTGCGCGGGGAGAAAAAGCGGATCACACGCCTGTGTGGTA
TATGAGGCAAGCAGGGCGCTCACAGCCGGAATACCGCAAGCTGAAGGAAAAGTACGGATTGTTTGAGATCACACATCAGC
CCGAACTTTGTGCGTATGTCACAAGACTGCCGGTTGAGCAATACGGAGTCGATGCTGCAATCCTTTATAAAGATATCATG
ACGCCGCTGCCGTCAATCGGTGTGGATGTTGAAATCAAAAACGGGATCGGTCCTGTGATTGATCAGCCAATCCGGTCTCT
GGCGGACATTGAAAAACTCGGCCAGATTGATCCGGAACAGGACGTGCCGTACGTGCTTGAGACGATTAAACTGCTTGTCA
ATGAGCAGCTGAACGTCCCGCTCATCGGTTTCTCAGGTGCGCCTTTTACGCTTGCAAGCTATATGATCGAAGGCGGCCCG
TCGAAAAACTACAATAAAACAAAAGCCTTCATGTACAGCATGCCAGATGCATGGAATCTGCTGATGTCCAAGCTTGCCGA
CATGATCATCGTGTACGTGAAAGCGCAGATTGAGGCAGGCGCAAAAGCGATTCAAATCTTTGATTCGTGGGTCGGCGCAT
TGAATCAGGCAGATTACAGAACATACATCAAACCCGTGATGAACCGGATCTTTTCAGAGCTCGCAAAGGAGAATGTGCCG
CTGATCATGTTTGGCGTTGGCGCAAGCCATCTTGCAGGTGATTGGCATGACCTTCCTCTCGATGTTGTCGGGCTTGACTG
GAGACTCGGCATTGATGAAGCCAGATCAAAAGGAATTACTAAAACAGTGCAGGGCAACCTGGACCCGTCCATTTTGCTTG
CGCCATGGGAAGTCATTGAGCAGAAAACGAAGGAAATACTTGATCAGGGTATGGAGTCAGACGGCTTCATTTTCAATCTT
GGCCATGGGGTATTTCCTGATGTCAGTCCCGAGGTTTTGAAAAAACTGACAGCATTTGTCCATGAATATTCACAAAACAA
AAAAATGGGTCAATATTCCTAA

Upstream 100 bases:

>100_bases
ACTTTGAGCTACATTTCTATACCATTTGCCTAAAACAAGGTATAGTGTAATAAGTCAAGAAATACGAACGTATGGTTGCC
GTATGAAAGGTGGAAATCAG

Downstream 100 bases:

>100_bases
GCATATCTTTTGGTATCTTAATGATATCCTGTCAAAATGTTTGTATCAGATCATTAAAGAGGGTGTAAACAGTGAGTAGA
AAGAAAATGGGGCTTCTCGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIM
TPLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP
SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVP
LIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNL
GHGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS

Sequences:

>Translated_353_residues
MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIM
TPLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP
SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVP
LIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNL
GHGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS
>Mature_352_residues
SKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMT
PLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGPS
KNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVPL
IMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLG
HGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=37.8531073446328, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI2367337, Length=349, Percent_Identity=39.541547277937, Blast_Score=248, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=350, Percent_Identity=32, Blast_Score=195, Evalue=7e-51,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=36.6279069767442, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=36.6279069767442, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_BACSU (P32395)

Other databases:

- EMBL:   M97208
- EMBL:   Y14083
- EMBL:   AL009126
- PIR:   B47045
- RefSeq:   NP_388893.1
- PDB:   2INF
- PDBsum:   2INF
- ProteinModelPortal:   P32395
- SMR:   P32395
- EnsemblBacteria:   EBBACT00000004111
- GeneID:   936296
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU10120
- NMPDR:   fig|224308.1.peg.1012
- GenoList:   BSU10120
- GeneTree:   EBGT00050000000611
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   P32395
- ProtClustDB:   PRK00115
- BioCyc:   BSUB:BSU10120-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39647; Mature: 39516

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 48-48 BINDING 78-78 BINDING 154-154 BINDING 209-209 BINDING 322-322

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHH
TRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQ
HHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
DVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGPSKNYNKTKAFMYSMPDAWNL
CCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCHHHHEEECCCHHHHH
LMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
LIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIE
EEEEECCHHHHCCCCCCCCEEEEECCEEECCHHHHCCCCCEECCCCCCCCEEECCHHHHH
QKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS
HHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYV
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHH
TRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQ
HHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
DVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGPSKNYNKTKAFMYSMPDAWNL
CCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCHHHHEEECCCHHHHH
LMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
LIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIE
EEEEECCHHHHCCCCCCCCEEEEECCEEECCHHHHCCCCCEECCCCCCCCEEECCHHHHH
QKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS
HHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377