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The map label for this gene is nhaC

Identifier: 16078033

GI number: 16078033

Start: 1042885

End: 1044246

Strand: Reverse

Name: nhaC

Synonym: BSU09680

Alternate gene names: 16078033

Gene position: 1044246-1042885 (Counterclockwise)

Preceding gene: 50812206

Following gene: 16078031

Centisome position: 24.77

GC content: 45.23

Gene sequence:

>1362_bases
TTGGATTCTCAAAAAAAGCTGACGTTTCCGTTAGCCGTCGGTTTATTTATATTCATGTTGTGCATTATTATTTCTTGCTT
ATTCTTGCTTCATGTAGAACCTCATATCCCGCTGTTTTTAAGTGTTGTCATGCTTTCAGCAGCAGCTTTATGGTTTGGAT
TTCCCTGGAAGAGCATTGAAAAAGGGATTGTAGACGGGATCAAAAACGGCGTACAGCCGATTATTGTTCTAGCGCTGATC
GGCATCTTAATCGGCGCCTGGATGTACAGCGGCGCAATACCGACTATGACAGTTTATGCCCTATCCTTTATTGAACCAAG
CCACCTTCTGTTGACTGCTTTGTTTTCATGTATGATCATCAGCACACTTGTTGGCTCAAGTCTGACAACTGTAAGCACAA
TCGGAGTAGCGCTGATCGGCGTGGCGAGCGCGGCTGGCGTTCCGCTTGAATGGACAGCAGGCGCAGTCATATGCGGCGCT
TGTTTTGGGGATAAAATGTCGCCGATGTCGGACACAACCAACTTTGCAGCCGGAATAGGCGAAATACCAATCTTTGAACA
CATTCGCCATATGATGGGCACAACCATTCCAGCTTTGCTCATCACTGTCGTTCTGTTTTACTTTCTCGGTTCATCAGTGT
CAGCGGACGCTGCTTCAACCGATAATATTCAGCAGGTCATAACCGGAATAAAAGATGCTGCAAACGTGACACCGTGGGCC
CTTCTTTCTCCGCTCTTAGTCGTTTTGCTGGCAATGAAACGGGTATCAGTAATCCCCGTTCTGACTGCCGGAATTATTTC
CTCGGGAATTTTGACTGCTATTTTTGTACCCTACAGCAGCCTGCAGGCGTTTATGACAGCTTTACAAAATGGCACAACTT
TCGAAACTGACAATGAGGCAGCCGCTAAAATTATTAACAGAGGCGGACTGCAATCCATGATGGGCTCTGTCTCTCTCATT
ATGATTGCTTTTGCACTCGGCGGATTGATGGAGAAAATCGGATTGATTTCTGCACTATTGGAAGGCGTCATGAAAGGCAT
CCGCTCAAAAGGCCGTCTTGTTGCAGCAACTGTCTGCTCAAGCATCGGCGTCAACTTGGCAACGGGCGAACAGTATTTAT
CGATATTAATACCGGGACAATCATTTAAATCTTTATATGACAAACGAAACATCCAGCGAAAATTTCTGACAAGATCATTA
GAGGACGGCGGAACATTAATTAACCCATTGATTCCTTGGGGCGTCAGCGGCGCATTTATGGCGAGCGCACTTGGTGTTCC
AGTCATAGACTACATCCCATTTACGTTCTTCCTCTATATATCGCCAATGATCTCCATTTTGATTGGATTTGTTAAAAAAT
AA

Upstream 100 bases:

>100_bases
ATTCATAATTGTGAAAAAACATAGATTTTCGTTTTTTTCTGTTATAATGCTTTCGTGCCCAAAAGCACAAAAGCATTAAA
GATAAATATGGGGTGTTATT

Downstream 100 bases:

>100_bases
AAAGAGCCCCGCTGTAAAAAGCGGGCTCTTTTCTTCGTTCATTTATGAAATGCTAGCAGCCTGTTGAATGCTTTCTTGAA
AAGCAGCCTGAAGCTGTTTG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALI
GILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA
CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWA
LLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLI
MIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSL
EDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK

Sequences:

>Translated_453_residues
MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALI
GILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA
CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWA
LLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLI
MIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSL
EDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK
>Mature_453_residues
MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALI
GILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA
CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWA
LLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLI
MIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSL
EDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAC_BACSU (O07553)

Other databases:

- EMBL:   Y14080
- EMBL:   AL009126
- PIR:   D69829
- RefSeq:   NP_388849.1
- ProteinModelPortal:   O07553
- EnsemblBacteria:   EBBACT00000000335
- GeneID:   936274
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09680
- NMPDR:   fig|224308.1.peg.968
- GenoList:   BSU09680
- GeneTree:   EBGT00050000000766
- HOGENOM:   HBG307651
- OMA:   HIKNMMY
- PhylomeDB:   O07553
- ProtClustDB:   CLSK886975
- BioCyc:   BSUB:BSU09680-MONOMER
- InterPro:   IPR004770
- InterPro:   IPR018461
- TIGRFAMs:   TIGR00931

Pfam domain/function: PF03553 Na_H_antiporter

EC number: NA

Molecular weight: Translated: 48054; Mature: 48054

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc79be3c)-; HASH(0xe03e2a4)-; HASH(0xdb78f94)-; HASH(0xe0ea738)-; HASH(0xd8a0a9c)-; HASH(0xd9a9a08)-; HASH(0xd339e7c)-; HASH(0xd9658c4)-; HASH(0xdcad0d0)-; HASH(0xdad52a4)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110