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The map label for this gene is bdhA

Identifier: 16077691

GI number: 16077691

Start: 677911

End: 678951

Strand: Reverse

Name: bdhA

Synonym: BSU06240

Alternate gene names: 16077691

Gene position: 678951-677911 (Counterclockwise)

Preceding gene: 255767155

Following gene: 16077689

Centisome position: 16.11

GC content: 47.55

Gene sequence:

>1041_bases
ATGAAGGCAGCAAGATGGCATAACCAAAAGGATATCCGTATTGAACATATCGAAGAGCCAAAAACGGAGCCGGGAAAAGT
AAAGATCAAAGTCAAATGGTGCGGCATCTGCGGAAGTGATTTACACGAATATCTGGGCGGCCCGATCTTTATTCCGGTTG
ACAAACCGCACCCATTAACAAATGAAACGGCACCTGTCACAATGGGGCATGAATTCTCCGGTGAAGTTGTCGAAGTCGGA
GAAGGCGTTGAAAATTATAAAGTTGGAGACCGCGTTGTAGTCGAGCCGATTTTTGCTACACACGGCCACCAAGGCGCCTA
CAACCTTGATGAACAAATGGGATTCCTCGGCTTAGCCGGCGGAGGCGGCGGTTTCTCTGAATACGTCTCTGTGGATGAAG
AGCTTTTGTTCAAACTTCCTGATGAATTATCATATGAACAAGGCGCGCTCGTTGAACCTTCTGCAGTTGCTCTATACGCT
GTCCGCTCAAGCAAACTCAAAGCAGGCGACAAAGCGGCTGTATTCGGCTGCGGCCCGATCGGACTTCTTGTCATTGAAGC
GCTGAAGGCTGCCGGTGCAACTGATATTTACGCTGTTGAGCTTTCTCCTGAACGCCAGCAAAAAGCTGAGGAGCTTGGCG
CGATCATCGTTGATCCGTCTAAAACAGACGATGTAGTCGCTGAGATTGCAGAACGTACAGGAGGCGGTGTTGACGTAGCA
TTCGAAGTCACTGGTGTCCCAGTGGTGTTACGACAAGCCATCCAGTCCACTACAATTGCCGGTGAAACCGTCATCGTCAG
CATTTGGGAAAAAGGTGCTGAAATCCATCCGAACGATATCGTAATCAAAGAACGTACAGTAAAAGGAATTATCGGATACC
GCGACATCTTCCCGGCTGTATTGTCATTAATGAAAGAAGGCTATTTCTCAGCCGACAAACTCGTAACGAAAAAAATCGTA
CTAGATGATTTGATCGAGGAAGGCTTCGGGGCTCTTATTAAAGAGAAAAGCCAAGTCAAAATCCTTGTTAGACCTAACTA
A

Upstream 100 bases:

>100_bases
ATTTCATTTCTTTTTTGGTTTTAAAAATGGCGATTTTGTGAACAGTTCATATTGACCGGTGCGGAATTACTCACATCAAA
AGTTATAGGAGTGGTAATCC

Downstream 100 bases:

>100_bases
TTTGAAACCAAAAAGAATCCGCACTCGGGTGCGGATTCTTTTTTAAATTATCCAATCACTTCAGCCCCAGAATCCTTCTT
TGCCCCGCTGTGATCATAAG

Product: acetoin reductase/2,3-butanediol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVG
EGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA
VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVA
FEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIV
LDDLIEEGFGALIKEKSQVKILVRPN

Sequences:

>Translated_346_residues
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVG
EGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA
VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVA
FEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIV
LDDLIEEGFGALIKEKSQVKILVRPN
>Mature_346_residues
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVG
EGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA
VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVA
FEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIV
LDDLIEEGFGALIKEKSQVKILVRPN

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=30.0911854103343, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI4501933, Length=380, Percent_Identity=30, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4501929, Length=379, Percent_Identity=29.8153034300792, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI34577061, Length=380, Percent_Identity=29.2105263157895, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI71565152, Length=385, Percent_Identity=27.012987012987, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=27.7333333333333, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI262073058, Length=375, Percent_Identity=27.7333333333333, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI71565154, Length=285, Percent_Identity=28.0701754385965, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=25.6267409470752, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=25.6267409470752, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=31.9402985074627, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788075, Length=351, Percent_Identity=29.9145299145299, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787863, Length=323, Percent_Identity=29.1021671826625, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790045, Length=356, Percent_Identity=27.8089887640449, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082125, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786825, Length=306, Percent_Identity=31.3725490196078, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=29.1925465838509, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788407, Length=312, Percent_Identity=27.5641025641026, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790718, Length=302, Percent_Identity=29.4701986754967, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786552, Length=379, Percent_Identity=28.7598944591029, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081918, Length=240, Percent_Identity=28.3333333333333, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=34.6268656716418, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=33.433734939759, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=26.7015706806283, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=26.3157894736842, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=270, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=378, Percent_Identity=36.2433862433862, Blast_Score=226, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6319258, Length=376, Percent_Identity=35.6382978723404, Blast_Score=202, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319955, Length=330, Percent_Identity=33.6363636363636, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322619, Length=330, Percent_Identity=33.6363636363636, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=31.7073170731707, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320033, Length=308, Percent_Identity=25.974025974026, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=274, Percent_Identity=25.1824817518248, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=273, Percent_Identity=25.2747252747253, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=278, Percent_Identity=25.1798561151079, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=259, Percent_Identity=25.8687258687259, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=31.2693498452012, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17737897, Length=323, Percent_Identity=30.9597523219814, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=28.8359788359788, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551930, Length=343, Percent_Identity=21.865889212828, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550770, Length=343, Percent_Identity=21.865889212828, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221457811, Length=343, Percent_Identity=21.865889212828, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BDHA_BACSU (O34788)

Other databases:

- EMBL:   AB007638
- EMBL:   AL009126
- PIR:   H69789
- RefSeq:   NP_388505.1
- HSSP:   P42328
- ProteinModelPortal:   O34788
- SMR:   O34788
- EnsemblBacteria:   EBBACT00000000967
- GeneID:   939490
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU06240
- NMPDR:   fig|224308.1.peg.624
- GenoList:   BSU06240
- GeneTree:   EBGT00050000000383
- HOGENOM:   HBG753318
- OMA:   IVIKERT
- PhylomeDB:   O34788
- ProtClustDB:   CLSK873763
- BioCyc:   BSUB:BSU06240-MONOMER
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.4

Molecular weight: Translated: 37341; Mature: 37341

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLT
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEECCCCCCCC
NETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAG
CCCCCEEECCCCCCCCEEECCCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHCCCEEEEEC
GGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYAVRSSKLKAGDKAAVFGCGPI
CCCCHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCHH
GLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVA
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCEEEE
FEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAV
EEECCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
LSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIKEKSQVKILVRPN
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLT
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEECCCCCCCC
NETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHGHQGAYNLDEQMGFLGLAG
CCCCCEEECCCCCCCCEEECCCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHCCCEEEEEC
GGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYAVRSSKLKAGDKAAVFGCGPI
CCCCHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCHH
GLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERTGGGVDVA
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCEEEE
FEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIHPNDIVIKERTVKGIIGYRDIFPAV
EEECCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
LSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIKEKSQVKILVRPN
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377