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The map label for this gene is xerD

Identifier: 15618932

GI number: 15618932

Start: 1176331

End: 1177236

Strand: Reverse

Name: xerD

Synonym: CPn1024

Alternate gene names: 15618932

Gene position: 1177236-1176331 (Counterclockwise)

Preceding gene: 15618938

Following gene: 15618930

Centisome position: 95.69

GC content: 46.14

Gene sequence:

>906_bases
ATGACTATGCCCTCGACTCAGTTTCACACAACGATTCTAGAACAATTCTCATTGTTTTTATCTGTAGATCGCGGCCTTTG
CCAACAATCTATAGCGGCTTACCGCCAAGACATCTCTTCCTTCCTTACCATAAGTGCCATTAGCTCCCCCCAAGATATTT
CACAAAACAGCGTATATATCTTTGCTGAAGAACTATATAGACGTAAAGAAGCAGAGACTACGTTAGCGCGTAGGCTCATT
GCTTTAAAAGTATTTTTTCTCTTCTTAAAAGATCAGCAACTTCTTCCCTATCCCCCAATAATAGAGCACCCAAAAATATG
GAAACGCCTTCCTTCAGTACTGACTCCTCAAGAAGTCGATGCTCTACTTGCGGTTCCTCTCCAAATGGAGAAAAACCCCC
GACACCTAGCCTTTCGTGATACAGCCATTCTCCACACACTATATTCAACTGGTGTCCGGGTTTCTGAACTTTGTGACCTA
CGTTTAGGCCATGTCTCTGATGATTGCATCCGCGTCACCGGGAAAGGTTCTAAAACCCGACTGGTGCCTCTGGGATCTCG
AGCAAGAGAAGCTATCGATGCGTACCTTTGTCCTTTCCGAGACCAATACCAGAAAAAGAATCCTCACGAAGATCATCTTT
TCCTCTCTACCCGGGGACACAAGCTCGAACGCTCTTGTGTGTGGCGCCGTATTCACAATTACGCAAAGCAAGTGACCTCA
AAGCCCGTATCTCCCCACTCCTTACGACACGCCTTTGCTACACATCTATTAGACAATAAGGCAGACCTACGCGTCATTCA
AGAGATGTTAGGTCACGCACGCATCGCCTCTACAGAAGTGTATACTCACGTAGCCGCGGATTCTCTAATCGAGAAGTTTC
TTGCCCATCACCCCAGGAATCTCTAA

Upstream 100 bases:

>100_bases
GTTGAATCGCAATCTATAAATCTTTTTCTTTCCATGGTTTTCTCTCTGTAGCTTGAAAATTGCTCCGCTCCCTATACTAA
AGTTACATTCGTTAGCGAGT

Downstream 100 bases:

>100_bases
TCGCATTCATAAAAAATTGTGCCATCTTCAAATCGGGTATAACATTCGCGACTTTCTTGACCTGTATTTTTAGTATAGCC
ATAAGTCTCTGGATAGTAAT

Product: site-specific tyrosine recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTMPSTQFHTTILEQFSLFLSVDRGLCQQSIAAYRQDISSFLTISAISSPQDISQNSVYIFAEELYRRKEAETTLARRLI
ALKVFFLFLKDQQLLPYPPIIEHPKIWKRLPSVLTPQEVDALLAVPLQMEKNPRHLAFRDTAILHTLYSTGVRVSELCDL
RLGHVSDDCIRVTGKGSKTRLVPLGSRAREAIDAYLCPFRDQYQKKNPHEDHLFLSTRGHKLERSCVWRRIHNYAKQVTS
KPVSPHSLRHAFATHLLDNKADLRVIQEMLGHARIASTEVYTHVAADSLIEKFLAHHPRNL

Sequences:

>Translated_301_residues
MTMPSTQFHTTILEQFSLFLSVDRGLCQQSIAAYRQDISSFLTISAISSPQDISQNSVYIFAEELYRRKEAETTLARRLI
ALKVFFLFLKDQQLLPYPPIIEHPKIWKRLPSVLTPQEVDALLAVPLQMEKNPRHLAFRDTAILHTLYSTGVRVSELCDL
RLGHVSDDCIRVTGKGSKTRLVPLGSRAREAIDAYLCPFRDQYQKKNPHEDHLFLSTRGHKLERSCVWRRIHNYAKQVTS
KPVSPHSLRHAFATHLLDNKADLRVIQEMLGHARIASTEVYTHVAADSLIEKFLAHHPRNL
>Mature_300_residues
TMPSTQFHTTILEQFSLFLSVDRGLCQQSIAAYRQDISSFLTISAISSPQDISQNSVYIFAEELYRRKEAETTLARRLIA
LKVFFLFLKDQQLLPYPPIIEHPKIWKRLPSVLTPQEVDALLAVPLQMEKNPRHLAFRDTAILHTLYSTGVRVSELCDLR
LGHVSDDCIRVTGKGSKTRLVPLGSRAREAIDAYLCPFRDQYQKKNPHEDHLFLSTRGHKLERSCVWRRIHNYAKQVTSK
PVSPHSLRHAFATHLLDNKADLRVIQEMLGHARIASTEVYTHVAADSLIEKFLAHHPRNL

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=296, Percent_Identity=37.8378378378378, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1790244, Length=302, Percent_Identity=33.7748344370861, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_CHLPN (Q9Z6N5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72005
- PIR:   E86618
- RefSeq:   NP_225218.1
- RefSeq:   NP_301079.1
- RefSeq:   NP_445367.1
- RefSeq:   NP_877335.1
- ProteinModelPortal:   Q9Z6N5
- SMR:   Q9Z6N5
- GeneID:   1467742
- GeneID:   895217
- GeneID:   918963
- GeneID:   962829
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0828
- KEGG:   cpn:CPn1024
- KEGG:   cpt:CpB1063
- TIGR:   CP_0828
- HOGENOM:   HBG727654
- OMA:   AIDAYLC
- ProtClustDB:   PRK00283
- BioCyc:   CPNE115711:CP_0828-MONOMER
- BioCyc:   CPNE115713:CPN1024-MONOMER
- BioCyc:   CPNE138677:CPJ1024-MONOMER
- BioCyc:   CPNE182082:CPB1063-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 34525; Mature: 34394

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: ACT_SITE 153-153 ACT_SITE 175-175 ACT_SITE 246-246 ACT_SITE 249-249 ACT_SITE 272-272 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPSTQFHTTILEQFSLFLSVDRGLCQQSIAAYRQDISSFLTISAISSPQDISQNSVYI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
FAEELYRRKEAETTLARRLIALKVFFLFLKDQQLLPYPPIIEHPKIWKRLPSVLTPQEVD
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHH
ALLAVPLQMEKNPRHLAFRDTAILHTLYSTGVRVSELCDLRLGHVSDDCIRVTGKGSKTR
HHHHCCHHCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCCCEE
LVPLGSRAREAIDAYLCPFRDQYQKKNPHEDHLFLSTRGHKLERSCVWRRIHNYAKQVTS
EEECCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHC
KPVSPHSLRHAFATHLLDNKADLRVIQEMLGHARIASTEVYTHVAADSLIEKFLAHHPRN
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
L
C
>Mature Secondary Structure 
TMPSTQFHTTILEQFSLFLSVDRGLCQQSIAAYRQDISSFLTISAISSPQDISQNSVYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
FAEELYRRKEAETTLARRLIALKVFFLFLKDQQLLPYPPIIEHPKIWKRLPSVLTPQEVD
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHH
ALLAVPLQMEKNPRHLAFRDTAILHTLYSTGVRVSELCDLRLGHVSDDCIRVTGKGSKTR
HHHHCCHHCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCCCEE
LVPLGSRAREAIDAYLCPFRDQYQKKNPHEDHLFLSTRGHKLERSCVWRRIHNYAKQVTS
EEECCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHC
KPVSPHSLRHAFATHLLDNKADLRVIQEMLGHARIASTEVYTHVAADSLIEKFLAHHPRN
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362