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The map label for this gene is uvrC

Identifier: 15618849

GI number: 15618849

Start: 1071201

End: 1073012

Strand: Reverse

Name: uvrC

Synonym: CPn0940

Alternate gene names: 15618849

Gene position: 1073012-1071201 (Counterclockwise)

Preceding gene: 15618850

Following gene: 15618847

Centisome position: 87.22

GC content: 41.5

Gene sequence:

>1812_bases
ATGCGCATTGAGGATTTTTCTCTCAAACTCATTCCTTCCTCTCCTGGAGTCTACCTGATGAAGGATGTCCATGATCAAGT
CCTCTACATTGGCAAGGCTAAAAATCTCAAAAATCGCTTAGCATCCTATTTTCATGAGAAAGGGGACTCTCGAGAACGCA
TCCCTTTTCTCATGAAAAAGACCGCGTCTATTGAAACTATTGTTGTGTCGAATGAAACTGAGGCCCTCCTTTTAGAAAAC
AATTTGATAAAGCAGCACCATCCTAAATACAATGTGTTGCTCAAAGATGATAAAACCTTTTTCTGCCTTGCGATTTCCCT
GTCACATTCGTGGCCCAAAGTGGAAGCTATCCGCACGAAGGCGATAACCTCTTCACAACGACAATTGATTTTTGGCCCTT
ATGTAAGTGCTGAAGCCTGCCACACTCTCTTAGAGGTTATCAGCCAATGGTTTCCTCTGAGGACTTGTTCAGATCGAGAG
TTTGCCTTAAGGAAACGCCCTTGCATTCTTTATGACATGAAGCGCTGTCTTGCTCCTTGTGTCGGCTATTGCACTCCTGA
AGAATATCAAGGAACCTTAGACAAGGCGATCCTCTTTCTTAAAGGAAAGATCGAAGAAGTGGTCAAGGACTTAGAAAAAG
TGATTCAAAAGGCTTCCGATAACTTAGAATTTGAGCAAGCTGCGAATTACTACCGCACGTTGTCCCTAATTAAGCAAGCT
ATGGCAAAGCAACAGGTGGAAAAATTTCATTTTCAAAATATTGATGCTCTTGGTCTTTACAGACATAAACAACGCACCAT
CCTCACGCTACTTACTGTCCGCTCAGGGAAGCTTCTTGGGGCACGCCATTTCTCTTTCTTTGAGAATGCTCAAGAAGATC
AAGACTTGCTCTCCTCTTTTATTTTGCAATATTATGTTAGCCAACCCTACATTCCTAAAGAAATTCTGACACCTCTTCCC
CTAGAATTTCCTACTCTCTCCTACGTATTGAATGCGGAGTCTCCTCCCCGCCTACGTTCTCCAAAAACAGGATATGGAAA
AGAACTTCTTGATCTAGCCTATCGCAATGCCAAGGCGTATGCAGCAACTACACTTCCTTCATCAACGCTCCCCTACCAAG
ACTTTCAAAATATACTGCGGATGTCACAATATCCGTATCGGATAGAATGCTACGATAATGCTCATATGCAAGGTGCTCAC
GCTACTGGAGTGTACATTGTATTTGAAAATAATGGGTTCGATCCCAAGCAATATCGTACGTTTTCCATAGATTCTGAAAA
GACTCAGAATGACTTGGCTCTATTAGAAGAAGTGCTCTTACGAAGGTTTCATTCACTGACCACAGCTCTTCCTGATATGA
TTGTGGTTGATGGGGGGAAAACGCACTATAACAAGACAAAAAAAATAATCCAAACTCTCAATCTTACAGGAATTCAGGTT
GTTACTATCGCAAAAGAAAAAAGTAATCATAGTCGAGGGTTAAATAAGGAGAAGATTTTCTGCGAGACGTTCCCAGAGGG
TTTTTCTCTTCCCCCGACTTCTAATTTATTACAATTTTTTCAGATCCTTCGTGATGAGGCACATCGCTTTGCGATTAGTA
AGCACAGGAAAAAAAGAGGAAAGGCTTTATTTGAACAGGAAAAAATCCCTGGAATCGGAGAGGTAAAGCGAAAACGATTG
TTGCAGAAATTTAAAAGTTGGAAACAGGTAATGCTTAGCTCCCAGGAAGAGCTGGAAGCTATTCCTGGGCTAACTAAGAA
AGATATTGCAGTGCTTCTTGCAAGGCAAAAAGACTTCAACAAATCTGATTAA

Upstream 100 bases:

>100_bases
TGGTATCGAGAGCTCAGCAGATCCTAAGACAATTAGAAGGCCCGGAATCCATTACACGCCCTGCTCAAGATAAGATGCAA
CAACTGACATTATTCTAGTT

Downstream 100 bases:

>100_bases
GTCTACCCTTCAGAATTCTCAAGTAAGAAGTCTTCAGGTGAAGGAAGATCTTGAACAGAGACTTCCTCTTCAATTTCTTC
ATCAATACGATCTTTTGGTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MRIEDFSLKLIPSSPGVYLMKDVHDQVLYIGKAKNLKNRLASYFHEKGDSRERIPFLMKKTASIETIVVSNETEALLLEN
NLIKQHHPKYNVLLKDDKTFFCLAISLSHSWPKVEAIRTKAITSSQRQLIFGPYVSAEACHTLLEVISQWFPLRTCSDRE
FALRKRPCILYDMKRCLAPCVGYCTPEEYQGTLDKAILFLKGKIEEVVKDLEKVIQKASDNLEFEQAANYYRTLSLIKQA
MAKQQVEKFHFQNIDALGLYRHKQRTILTLLTVRSGKLLGARHFSFFENAQEDQDLLSSFILQYYVSQPYIPKEILTPLP
LEFPTLSYVLNAESPPRLRSPKTGYGKELLDLAYRNAKAYAATTLPSSTLPYQDFQNILRMSQYPYRIECYDNAHMQGAH
ATGVYIVFENNGFDPKQYRTFSIDSEKTQNDLALLEEVLLRRFHSLTTALPDMIVVDGGKTHYNKTKKIIQTLNLTGIQV
VTIAKEKSNHSRGLNKEKIFCETFPEGFSLPPTSNLLQFFQILRDEAHRFAISKHRKKRGKALFEQEKIPGIGEVKRKRL
LQKFKSWKQVMLSSQEELEAIPGLTKKDIAVLLARQKDFNKSD

Sequences:

>Translated_603_residues
MRIEDFSLKLIPSSPGVYLMKDVHDQVLYIGKAKNLKNRLASYFHEKGDSRERIPFLMKKTASIETIVVSNETEALLLEN
NLIKQHHPKYNVLLKDDKTFFCLAISLSHSWPKVEAIRTKAITSSQRQLIFGPYVSAEACHTLLEVISQWFPLRTCSDRE
FALRKRPCILYDMKRCLAPCVGYCTPEEYQGTLDKAILFLKGKIEEVVKDLEKVIQKASDNLEFEQAANYYRTLSLIKQA
MAKQQVEKFHFQNIDALGLYRHKQRTILTLLTVRSGKLLGARHFSFFENAQEDQDLLSSFILQYYVSQPYIPKEILTPLP
LEFPTLSYVLNAESPPRLRSPKTGYGKELLDLAYRNAKAYAATTLPSSTLPYQDFQNILRMSQYPYRIECYDNAHMQGAH
ATGVYIVFENNGFDPKQYRTFSIDSEKTQNDLALLEEVLLRRFHSLTTALPDMIVVDGGKTHYNKTKKIIQTLNLTGIQV
VTIAKEKSNHSRGLNKEKIFCETFPEGFSLPPTSNLLQFFQILRDEAHRFAISKHRKKRGKALFEQEKIPGIGEVKRKRL
LQKFKSWKQVMLSSQEELEAIPGLTKKDIAVLLARQKDFNKSD
>Mature_603_residues
MRIEDFSLKLIPSSPGVYLMKDVHDQVLYIGKAKNLKNRLASYFHEKGDSRERIPFLMKKTASIETIVVSNETEALLLEN
NLIKQHHPKYNVLLKDDKTFFCLAISLSHSWPKVEAIRTKAITSSQRQLIFGPYVSAEACHTLLEVISQWFPLRTCSDRE
FALRKRPCILYDMKRCLAPCVGYCTPEEYQGTLDKAILFLKGKIEEVVKDLEKVIQKASDNLEFEQAANYYRTLSLIKQA
MAKQQVEKFHFQNIDALGLYRHKQRTILTLLTVRSGKLLGARHFSFFENAQEDQDLLSSFILQYYVSQPYIPKEILTPLP
LEFPTLSYVLNAESPPRLRSPKTGYGKELLDLAYRNAKAYAATTLPSSTLPYQDFQNILRMSQYPYRIECYDNAHMQGAH
ATGVYIVFENNGFDPKQYRTFSIDSEKTQNDLALLEEVLLRRFHSLTTALPDMIVVDGGKTHYNKTKKIIQTLNLTGIQV
VTIAKEKSNHSRGLNKEKIFCETFPEGFSLPPTSNLLQFFQILRDEAHRFAISKHRKKRGKALFEQEKIPGIGEVKRKRL
LQKFKSWKQVMLSSQEELEAIPGLTKKDIAVLLARQKDFNKSD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=603, Percent_Identity=32.3383084577114, Blast_Score=292, Evalue=5e-80,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHLPN (Q9Z6W6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86608
- PIR:   F72017
- RefSeq:   NP_225135.1
- RefSeq:   NP_300997.1
- RefSeq:   NP_445458.1
- RefSeq:   NP_877246.1
- ProteinModelPortal:   Q9Z6W6
- GeneID:   1467653
- GeneID:   895526
- GeneID:   919702
- GeneID:   963381
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0921
- KEGG:   cpn:CPn0940
- KEGG:   cpt:CpB0974
- TIGR:   CP_0921
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q9Z6W6
- ProtClustDB:   PRK00558
- BioCyc:   CPNE115711:CP_0921-MONOMER
- BioCyc:   CPNE115713:CPN0940-MONOMER
- BioCyc:   CPNE138677:CPJ0940-MONOMER
- BioCyc:   CPNE182082:CPB0974-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69427; Mature: 69427

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEDFSLKLIPSSPGVYLMKDVHDQVLYIGKAKNLKNRLASYFHEKGDSRERIPFLMKK
CCCCCCEEEEECCCCCEEEEHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHC
TASIETIVVSNETEALLLENNLIKQHHPKYNVLLKDDKTFFCLAISLSHSWPKVEAIRTK
CCCEEEEEEECCCCEEEEECCHHHHCCCCEEEEEECCCEEEEEEEEECCCCCHHHHHHHH
AITSSQRQLIFGPYVSAEACHTLLEVISQWFPLRTCSDREFALRKRPCILYDMKRCLAPC
HHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
VGYCTPEEYQGTLDKAILFLKGKIEEVVKDLEKVIQKASDNLEFEQAANYYRTLSLIKQA
HCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MAKQQVEKFHFQNIDALGLYRHKQRTILTLLTVRSGKLLGARHFSFFENAQEDQDLLSSF
HHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCEECHHHHHHHHCCCHHHHHHHHH
ILQYYVSQPYIPKEILTPLPLEFPTLSYVLNAESPPRLRSPKTGYGKELLDLAYRNAKAY
HHHHHHCCCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AATTLPSSTLPYQDFQNILRMSQYPYRIECYDNAHMQGAHATGVYIVFENNGFDPKQYRT
EEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHEEE
FSIDSEKTQNDLALLEEVLLRRFHSLTTALPDMIVVDGGKTHYNKTKKIIQTLNLTGIQV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCEEE
VTIAKEKSNHSRGLNKEKIFCETFPEGFSLPPTSNLLQFFQILRDEAHRFAISKHRKKRG
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALFEQEKIPGIGEVKRKRLLQKFKSWKQVMLSSQEELEAIPGLTKKDIAVLLARQKDFN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHCCCCC
KSD
CCC
>Mature Secondary Structure
MRIEDFSLKLIPSSPGVYLMKDVHDQVLYIGKAKNLKNRLASYFHEKGDSRERIPFLMKK
CCCCCCEEEEECCCCCEEEEHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHC
TASIETIVVSNETEALLLENNLIKQHHPKYNVLLKDDKTFFCLAISLSHSWPKVEAIRTK
CCCEEEEEEECCCCEEEEECCHHHHCCCCEEEEEECCCEEEEEEEEECCCCCHHHHHHHH
AITSSQRQLIFGPYVSAEACHTLLEVISQWFPLRTCSDREFALRKRPCILYDMKRCLAPC
HHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
VGYCTPEEYQGTLDKAILFLKGKIEEVVKDLEKVIQKASDNLEFEQAANYYRTLSLIKQA
HCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MAKQQVEKFHFQNIDALGLYRHKQRTILTLLTVRSGKLLGARHFSFFENAQEDQDLLSSF
HHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCEECHHHHHHHHCCCHHHHHHHHH
ILQYYVSQPYIPKEILTPLPLEFPTLSYVLNAESPPRLRSPKTGYGKELLDLAYRNAKAY
HHHHHHCCCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AATTLPSSTLPYQDFQNILRMSQYPYRIECYDNAHMQGAHATGVYIVFENNGFDPKQYRT
EEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHEEE
FSIDSEKTQNDLALLEEVLLRRFHSLTTALPDMIVVDGGKTHYNKTKKIIQTLNLTGIQV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCEEE
VTIAKEKSNHSRGLNKEKIFCETFPEGFSLPPTSNLLQFFQILRDEAHRFAISKHRKKRG
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALFEQEKIPGIGEVKRKRLLQKFKSWKQVMLSSQEELEAIPGLTKKDIAVLLARQKDFN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHCCCCC
KSD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362