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The map label for this gene is hemE

Identifier: 15618799

GI number: 15618799

Start: 1016816

End: 1017805

Strand: Reverse

Name: hemE

Synonym: CPn0890

Alternate gene names: 15618799

Gene position: 1017805-1016816 (Counterclockwise)

Preceding gene: 15618800

Following gene: 15618798

Centisome position: 82.73

GC content: 40.3

Gene sequence:

>990_bases
ATGTCTGCTTTTTTTGATCTTTTAAAATCTCAAACTGCCTCTCATCCTCCCATATGGCTATTACGACAGGTAGGAAGGTA
CATGCCTCCATACCAAGAGCTGAAAGGATCCCAATCTTTAAAAACCTTTTTCCATAATACTGAAGCTATTGTAGAGGCTA
CGCTTTTAGGGCCCTCGTTGCTACATGTAGATGCTGCTATTCTCTTTGCTGATATCCTATCCATCTTGGATGGTTTTGCT
GTGACCTATGACTTTGCTCCTGGTCCGCGCATACAATTTTCTCCAGAGCAACCTTTCACTTTCACTTCCGATCCACAAAC
CATCTTTAGCTATCTTTTGGACGCGATTCGAACTCTTAAGCAAAAACTTCCTGTTCCGCTGATTGTTTTTGCAGCATCTC
CCTTCACACTCGCCTGCTACTTAATTGATGGAGGTGCTTCCAAAGATTTTTCTAAGACCATGTCTTTTCTCTATGTGTAT
CCTGAAAAATTTGATCAGCTCATCTCTACAATTATCGAAGGGACTGCTATTTATCTAAAAACACAAATGGATGCAGGAGC
TGCTGCTGTGCAGCTTTTTGAATCTTCGAGTCTACGTCTCCCTTCAGCACTCTTTACACGCTATGTGACTGAACCAAACC
GTCGTCTGATAGCAAAACTTAAAGAGCAGGCCATTCCTGTGAGTTTATTTTGTCGTTGTTTTGAAGAAAATTTTTATACT
CTGCAAGCCACGCAAGCCGATACACTCCATCCTGATTATCATGTGGACCTTCATCGCATACAAAAAAATCTTATGCTCTC
CCTACAAGGAAACTTGGATCCGGCAATATTTTTATTGCCCCAAGAGAAATTATTACACTATGTAGAAGCCTTCCTTGTTC
CTTTAAGAACATATCCTAACTTCATTTTTAATTCTGGACATGGGATTCTTCCTGAAACACCTTTAGAAAACGTCCAATTG
GTAGTTTCTTATGTTCAACGTCAACTTTAA

Upstream 100 bases:

>100_bases
TTGCCCTATGCTCTATCTCCAACTCCTGAACTTCTAGTCAAAGAAGTCATTGAGTCCATAGAAAGGGGCTTCTTAATCAA
CGCTTCATAATTGGGACTCT

Downstream 100 bases:

>100_bases
ATTCTTAGAAGGACTTCATCAACCCGCGCCCAGATACACAAGCTACCCTACAGCTTTAGAATGGGAACCTTCCGATGCGG
CTCCAGCTCTTCTAGCGTTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSAFFDLLKSQTASHPPIWLLRQVGRYMPPYQELKGSQSLKTFFHNTEAIVEATLLGPSLLHVDAAILFADILSILDGFA
VTYDFAPGPRIQFSPEQPFTFTSDPQTIFSYLLDAIRTLKQKLPVPLIVFAASPFTLACYLIDGGASKDFSKTMSFLYVY
PEKFDQLISTIIEGTAIYLKTQMDAGAAAVQLFESSSLRLPSALFTRYVTEPNRRLIAKLKEQAIPVSLFCRCFEENFYT
LQATQADTLHPDYHVDLHRIQKNLMLSLQGNLDPAIFLLPQEKLLHYVEAFLVPLRTYPNFIFNSGHGILPETPLENVQL
VVSYVQRQL

Sequences:

>Translated_329_residues
MSAFFDLLKSQTASHPPIWLLRQVGRYMPPYQELKGSQSLKTFFHNTEAIVEATLLGPSLLHVDAAILFADILSILDGFA
VTYDFAPGPRIQFSPEQPFTFTSDPQTIFSYLLDAIRTLKQKLPVPLIVFAASPFTLACYLIDGGASKDFSKTMSFLYVY
PEKFDQLISTIIEGTAIYLKTQMDAGAAAVQLFESSSLRLPSALFTRYVTEPNRRLIAKLKEQAIPVSLFCRCFEENFYT
LQATQADTLHPDYHVDLHRIQKNLMLSLQGNLDPAIFLLPQEKLLHYVEAFLVPLRTYPNFIFNSGHGILPETPLENVQL
VVSYVQRQL
>Mature_328_residues
SAFFDLLKSQTASHPPIWLLRQVGRYMPPYQELKGSQSLKTFFHNTEAIVEATLLGPSLLHVDAAILFADILSILDGFAV
TYDFAPGPRIQFSPEQPFTFTSDPQTIFSYLLDAIRTLKQKLPVPLIVFAASPFTLACYLIDGGASKDFSKTMSFLYVYP
EKFDQLISTIIEGTAIYLKTQMDAGAAAVQLFESSSLRLPSALFTRYVTEPNRRLIAKLKEQAIPVSLFCRCFEENFYTL
QATQADTLHPDYHVDLHRIQKNLMLSLQGNLDPAIFLLPQEKLLHYVEAFLVPLRTYPNFIFNSGHGILPETPLENVQLV
VSYVQRQL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=343, Percent_Identity=29.4460641399417, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI2367337, Length=330, Percent_Identity=29.3939393939394, Blast_Score=162, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320252, Length=332, Percent_Identity=29.8192771084337, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=31.4705882352941, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221330099, Length=340, Percent_Identity=31.4705882352941, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CHLPN (Q9Z716)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   F72023
- PIR:   H86601
- RefSeq:   NP_225085.1
- RefSeq:   NP_300947.1
- RefSeq:   NP_445513.1
- RefSeq:   NP_877193.1
- ProteinModelPortal:   Q9Z716
- SMR:   Q9Z716
- GeneID:   1467600
- GeneID:   895681
- GeneID:   919654
- GeneID:   963444
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0976
- KEGG:   cpn:CPn0890
- KEGG:   cpt:CpB0921
- TIGR:   CP_0976
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   CPNE115711:CP_0976-MONOMER
- BioCyc:   CPNE115713:CPN0890-MONOMER
- BioCyc:   CPNE138677:CPJ0890-MONOMER
- BioCyc:   CPNE182082:CPB0921-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37166; Mature: 37035

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 71-71 BINDING 140-140 BINDING 195-195 BINDING 307-307

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFFDLLKSQTASHPPIWLLRQVGRYMPPYQELKGSQSLKTFFHNTEAIVEATLLGPSL
CHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHCCHHHHHHHHHCCCHH
LHVDAAILFADILSILDGFAVTYDFAPGPRIQFSPEQPFTFTSDPQTIFSYLLDAIRTLK
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCEECCCHHHHHHHHHHHHHHHH
QKLPVPLIVFAASPFTLACYLIDGGASKDFSKTMSFLYVYPEKFDQLISTIIEGTAIYLK
HHCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHHHEEECHHHHHHHHHHHHCCCEEEEE
TQMDAGAAAVQLFESSSLRLPSALFTRYVTEPNRRLIAKLKEQAIPVSLFCRCFEENFYT
ECCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEE
LQATQADTLHPDYHVDLHRIQKNLMLSLQGNLDPAIFLLPQEKLLHYVEAFLVPLRTYPN
EEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC
FIFNSGHGILPETPLENVQLVVSYVQRQL
CEEECCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAFFDLLKSQTASHPPIWLLRQVGRYMPPYQELKGSQSLKTFFHNTEAIVEATLLGPSL
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHCCHHHHHHHHHCCCHH
LHVDAAILFADILSILDGFAVTYDFAPGPRIQFSPEQPFTFTSDPQTIFSYLLDAIRTLK
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCEECCCHHHHHHHHHHHHHHHH
QKLPVPLIVFAASPFTLACYLIDGGASKDFSKTMSFLYVYPEKFDQLISTIIEGTAIYLK
HHCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHHHEEECHHHHHHHHHHHHCCCEEEEE
TQMDAGAAAVQLFESSSLRLPSALFTRYVTEPNRRLIAKLKEQAIPVSLFCRCFEENFYT
ECCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEE
LQATQADTLHPDYHVDLHRIQKNLMLSLQGNLDPAIFLLPQEKLLHYVEAFLVPLRTYPN
EEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC
FIFNSGHGILPETPLENVQLVVSYVQRQL
CEEECCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362