Click here to switch to the map view.

The map label for this gene is serS

Identifier: 15618779

GI number: 15618779

Start: 987445

End: 988728

Strand: Reverse

Name: serS

Synonym: CPn0870

Alternate gene names: 15618779

Gene position: 988728-987445 (Counterclockwise)

Preceding gene: 15618783

Following gene: 15618778

Centisome position: 80.37

GC content: 42.37

Gene sequence:

>1284_bases
ATGTTGGATATAAAAATTATACGCAAGACTCCCGAAGAATGTGAAACTCGACTTCGTAAAAAAGATCCAAAAATTTCTTT
AGAACCTGTACTCTCCTTGGATAAAGAGGTCCGTCAACTCAAGACGGATTCAGAAACTTTACAAGCACAAAGACGCCTCT
TATCTCAAGATATACATAAAGCTAAAACGCAAGGGGTAGACGCGACAAACTTAATTCAAGAGGTAGAGACTCTTGCTGCG
GATCTTGAAAAAATTGAGCAGCACCTCGATCAAAAAAACGCTCAACTACATGAATTGCTGAGCCATCTTCCTAATTACCC
TGCTGACGACATTCCTGTATCCGAGGACAAAGCGGGAAATCAAGTCATTAAAAGTGTTGGGGACCTTCCTATATTTTCCT
TTCCTCCGAAGCATCACTTAGAGCTAAATCAGGAGTTAGACATCTTAGATTTCCAAGCAGCAGCAAAAACGACAGGATCA
GGATGGCCTGCTTATAAAAATCGTGGTGTTCTTCTGGAATGGGCTCTTCTTACGTATATGTTACAGAAGCAAGCAGCTCA
TGGATTTCAGCTCTGGCTTCCCCCCTTATTAGTGAAGAAAGAAATTTTATTTGGCTCTGGGCAGATTCCGAAATTTGATG
GACAATACTATCGTGTTGAGGACGGAGAGCAGTATCTCTATCTGATCCCCACTGCGGAAGTCGTTCTTAATGGGTTTCGT
TCCCAAGACATTTTAACAGAAAAAGAACTTCCTCTTTACTATGCTGCGTGCACTCCGTGCTTCCGAAGAGAAGCAGGTGC
TGCAGGAGCTCAAGAGAGAGGACTTGTGCGGGTGCATCAATTCCATAAGGTAGAAATGTTTGCCTTTACAACACCCAATC
AAGATGATATTGCTTATGAAAAAATGCTTAGTATTGTTGAAGAAATGCTGACAGAGCTCAAGTTGCCTTATCGTCTTTCT
TTGCTTTCTACGGGGGATATGTCTTTTACAGCATCCAAGACTATAGATGCTGAGGTCTGGTTGCCAGGACAAAAAGCTTT
TTATGAAGTGTCTTCTATTTCTCAGTGTACGGATTTCCAATCGCGGCGCTCTGGGACTCGCTATAAAGATAGCCAAGGGA
AACTACAGTTTGTTCATACTCTTAACGGTTCAGGTCTGGCAACACCACGTCTCTTGGTAGCTATTTTAGAAAATAACCAA
CAAGCTGATGGCTCTGTGGTTATTCCTGAAGTCCTTCGTCCTTATTTAGGAGGGTTGGAGATTCTTCTTCCCAAAGACCA
GTGA

Upstream 100 bases:

>100_bases
TCCGATTTCTATAGCACGCCGCATAAAAAAGAGTTGTTGCTCAGAGAAATCTTCCATATACTCTCACTTTTGCACACTTC
TACTTAACAATGAGACAAGC

Downstream 100 bases:

>100_bases
GAACACATCAGACTGTAGACAGCATCAAATTCTAAGGAAAATTATGACTCAGGATCCACATGACCACTTTAAATCACGCA
CTCCAGAGGACCACATAAAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHKAKTQGVDATNLIQEVETLAA
DLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGNQVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGS
GWPAYKNRGVLLEWALLTYMLQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFR
SQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYEKMLSIVEEMLTELKLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQSRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQ
QADGSVVIPEVLRPYLGGLEILLPKDQ

Sequences:

>Translated_427_residues
MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHKAKTQGVDATNLIQEVETLAA
DLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGNQVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGS
GWPAYKNRGVLLEWALLTYMLQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFR
SQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYEKMLSIVEEMLTELKLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQSRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQ
QADGSVVIPEVLRPYLGGLEILLPKDQ
>Mature_427_residues
MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHKAKTQGVDATNLIQEVETLAA
DLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGNQVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGS
GWPAYKNRGVLLEWALLTYMLQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFR
SQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYEKMLSIVEEMLTELKLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQSRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQ
QADGSVVIPEVLRPYLGGLEILLPKDQ

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=439, Percent_Identity=34.3963553530752, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI225579074, Length=326, Percent_Identity=38.3435582822086, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=30.6034482758621, Blast_Score=191, Evalue=8e-49,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=40.3263403263403, Blast_Score=307, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17539260, Length=454, Percent_Identity=30.3964757709251, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=261, Percent_Identity=34.4827586206897, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=416, Percent_Identity=33.6538461538462, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=399, Percent_Identity=31.8295739348371, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=28.6624203821656, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737985, Length=284, Percent_Identity=35.9154929577465, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CHLPN (Q9Z736)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86599
- PIR:   F72026
- RefSeq:   NP_225065.1
- RefSeq:   NP_300927.1
- RefSeq:   NP_445536.1
- RefSeq:   NP_877171.1
- ProteinModelPortal:   Q9Z736
- SMR:   Q9Z736
- PHCI-2DPAGE:   Q9Z736
- GeneID:   1467578
- GeneID:   895685
- GeneID:   919633
- GeneID:   963472
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0999
- KEGG:   cpn:CPn0870
- KEGG:   cpt:CpB0899
- TIGR:   CP_0999
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- PhylomeDB:   Q9Z736
- ProtClustDB:   PRK05431
- BioCyc:   CPNE115711:CP_0999-MONOMER
- BioCyc:   CPNE115713:CPN0870-MONOMER
- BioCyc:   CPNE138677:CPJ0870-MONOMER
- BioCyc:   CPNE182082:CPB0899-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48232; Mature: 48232

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 278-278 BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHK
CCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AKTQGVDATNLIQEVETLAADLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHH
QVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGSGWPAYKNRGVLLEWALLTYM
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
LQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFR
HHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECHHHHHHHCCC
SQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYE
CCCCCCCCCCCEEEECCCHHHHHHCCCCCCHHCCCHHHHHHEEEEEEEEECCCCCHHHHH
KMLSIVEEMLTELKLPYRLSLLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
SRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQQADGSVVIPEVLRPYLGGLE
HHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEECHHHHHHHHCCEE
ILLPKDQ
EEECCCC
>Mature Secondary Structure
MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHK
CCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AKTQGVDATNLIQEVETLAADLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHH
QVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGSGWPAYKNRGVLLEWALLTYM
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
LQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFR
HHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECHHHHHHHCCC
SQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYE
CCCCCCCCCCCEEEECCCHHHHHHCCCCCCHHCCCHHHHHHEEEEEEEEECCCCCHHHHH
KMLSIVEEMLTELKLPYRLSLLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
SRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQQADGSVVIPEVLRPYLGGLE
HHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEECHHHHHHHHCCEE
ILLPKDQ
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362