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The map label for this gene is ndk

Identifier: 15618529

GI number: 15618529

Start: 713010

End: 713444

Strand: Reverse

Name: ndk

Synonym: CPn0619

Alternate gene names: 15618529

Gene position: 713444-713010 (Counterclockwise)

Preceding gene: 15618530

Following gene: 15618525

Centisome position: 57.99

GC content: 40.69

Gene sequence:

>435_bases
ATGGAACAAACGCTATCCATTATTAAACCAGATTCTGTTAGCAAAGCCCATATCGGAGAGATCTTATCTATTTTTGAACA
ATCTGGATTACGTATAGCTGCTATGAAAATGATGCACCTATCCCAAACTGAAGCCGAAGGGTTTTATTTTGTGCATAGAG
AGCGTCCTTTTTTCCAAGAACTTGTTGATTTTATGGTCTCAGGCCCTGTTGTAGTTTTAGTATTGGAAGGGGCAAATGCC
GTTTCCCGAAATCGTGAACTTATGGGAGCTACAAATCCTGCAGAAGCTGCTTCAGGAACCATTCGAGCTAAGTTTGGGGA
ATCTATAGGCGTGAATGCTGTTCATGGATCTGATACTTTAGAAAATGCTGCTGTCGAAATCGCTTACTTCTTCAGTAAGA
TAGAAGTTGTTAACGCTTCGAAACCTCTCGTTTAG

Upstream 100 bases:

>100_bases
AGAATTTTTCAGGAGTGAACAAGGACTAGACTTTCCTAAAGATCATGCTATACTCCTCCTAAAATAAAACGATTTTATTT
AAAGGAGATATGTATACACC

Downstream 100 bases:

>100_bases
TTTAGTACTGTAGTTGCTTTACGATGAGGTTGAGCAAGAATTTCTTCTAGCTCATTATCAAGAAATTCTTCCCAGGTAAA
CAACAAACTACCAGATGCCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MEQTLSIIKPDSVSKAHIGEILSIFEQSGLRIAAMKMMHLSQTEAEGFYFVHRERPFFQELVDFMVSGPVVVLVLEGANA
VSRNRELMGATNPAEAASGTIRAKFGESIGVNAVHGSDTLENAAVEIAYFFSKIEVVNASKPLV

Sequences:

>Translated_144_residues
MEQTLSIIKPDSVSKAHIGEILSIFEQSGLRIAAMKMMHLSQTEAEGFYFVHRERPFFQELVDFMVSGPVVVLVLEGANA
VSRNRELMGATNPAEAASGTIRAKFGESIGVNAVHGSDTLENAAVEIAYFFSKIEVVNASKPLV
>Mature_144_residues
MEQTLSIIKPDSVSKAHIGEILSIFEQSGLRIAAMKMMHLSQTEAEGFYFVHRERPFFQELVDFMVSGPVVVLVLEGANA
VSRNRELMGATNPAEAASGTIRAKFGESIGVNAVHGSDTLENAAVEIAYFFSKIEVVNASKPLV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=43.4782608695652, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=43.4782608695652, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=43.4782608695652, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=43.4782608695652, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=43.4782608695652, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=43.1654676258993, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=43.1654676258993, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=43.3823529411765, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=39.4160583941606, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=42.1052631578947, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=42.1052631578947, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=35.036496350365, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=32.6086956521739, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=53.1914893617021, Blast_Score=158, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=143, Percent_Identity=39.1608391608392, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=40.8759124087591, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=43.1654676258993, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18860097, Length=144, Percent_Identity=29.8611111111111, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHLPN (Q9Z7T5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   G72056
- PIR:   H86567
- RefSeq:   NP_224815.1
- RefSeq:   NP_300675.1
- RefSeq:   NP_444680.1
- RefSeq:   NP_876917.1
- ProteinModelPortal:   Q9Z7T5
- SMR:   Q9Z7T5
- PHCI-2DPAGE:   Q9Z7T5
- GeneID:   1467324
- GeneID:   895417
- GeneID:   919383
- GeneID:   963007
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0128
- KEGG:   cpn:CPn0619
- KEGG:   cpt:CpB0645
- TIGR:   CP_0128
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q9Z7T5
- ProtClustDB:   PRK00668
- BioCyc:   CPNE115711:CP_0128-MONOMER
- BioCyc:   CPNE115713:CPN0619-MONOMER
- BioCyc:   CPNE138677:CPJ0619-MONOMER
- BioCyc:   CPNE182082:CPB0645-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15642; Mature: 15642

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTLSIIKPDSVSKAHIGEILSIFEQSGLRIAAMKMMHLSQTEAEGFYFVHRERPFFQE
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCEEEEECCCCHHHH
LVDFMVSGPVVVLVLEGANAVSRNRELMGATNPAEAASGTIRAKFGESIGVNAVHGSDTL
HHHHHHCCCEEEEEECCCCCHHCCCHHCCCCCCCHHCCCEEEEECCCCCCCEEEECCCCH
ENAAVEIAYFFSKIEVVNASKPLV
HHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MEQTLSIIKPDSVSKAHIGEILSIFEQSGLRIAAMKMMHLSQTEAEGFYFVHRERPFFQE
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCEEEEECCCCHHHH
LVDFMVSGPVVVLVLEGANAVSRNRELMGATNPAEAASGTIRAKFGESIGVNAVHGSDTL
HHHHHHCCCEEEEEECCCCCHHCCCHHCCCCCCCHHCCCEEEEECCCCCCCEEEECCCCH
ENAAVEIAYFFSKIEVVNASKPLV
HHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362