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The map label for this gene is gyrA_1

Identifier: 15618194

GI number: 15618194

Start: 305849

End: 308353

Strand: Reverse

Name: gyrA_1

Synonym: CPn0274

Alternate gene names: 15618194

Gene position: 308353-305849 (Counterclockwise)

Preceding gene: 15618195

Following gene: 15618193

Centisome position: 25.06

GC content: 41.0

Gene sequence:

>2505_bases
ATGTTCAATAAAGATGAAATTATAGTCCCTAAAAATCTTGAAGAAGAGATGAAGGAAAGTTACCTTCGTTATTCGATGTC
TGTGATTATATCTCGGGCTCTTCCAGATATCCGGGATGGACTCAAGCCTTCACAAAGAAGAGTTCTTTATGCCATGAAGC
AGCTAAGTCTTTCTCCAGGAGCTAAGCATCGTAAATGTGCAAAAATTTGTGGGGATACCTCTGGAGACTACCATCCACAT
GGTGAGAGCGTCATTTATCCTACGCTTGTCCGTATGGCTCAGAACTGGGCGATGCGTTATCCTTTGGTGGACGGACAAGG
AAACTTCGGCTCCATAGACGGAGATCCACCTGCTGCTATGCGATACACAGAAGCTCGTCTTACCCATAGTGCTATGTATC
TTATGGAAGACTTGGACAAAGATACTGTGGATATTGTTCCAAACTATGATGAAACAAAACACGAGCCTGTAGTTTTTCCT
TCTAAATTTCCGAATCTTCTTTGCAATGGTTCTTCAGGAATTGCTGTTGGGATGGCAACGAATATCCCCCCACACAATTT
AGGGGAACTTATAGAAGCTACACTTCTTCTGCTTGCAAATCCACAGGCTTCTGTGGATGAGATTTTACAAGTCATGCCAG
GCCCTGATTTCCCTACAGGAGGAATTATCTGCGGTTCTGAAGGAATTCGCTCCGCGTATACTACAGGACGAGGAAAGATT
AAAGTTCGAGCTCGTCTGCATGTAGAAGAGAATGAAGATAAACATCGTGAGAGCATCATCATCACAGAGATGCCTTATAA
TGTGAATAAATCACGTTTGATTGAGCAAATTGCAAATCTTGTGAATGAAAAGACTCTCGCAGGCATTTCAGATGTTCGCG
ATGAGTCTGATAAAGATGGAATCCGTGTTGTCCTTGAAATCAAAAAAGGAGAATCTTCGGAAATCATTATCAATAGGCTC
TACAAGTTCACCGATGTTCAGGTAACTTTTGGGGCAAATATGCTTGCCCTGGATAAGAACTTACCTAGAACGATGAGTAT
TCATAGGATGATTTCCGCTTGGATACGCCATCGTAAAGAAGTCATCCGTCGTAGGACTCGTTATGAATTAAATAAAGCAG
AAACACGAGCTCATGTTTTAGAAGGATACCTTAAGGCTTTATCTTGCTTAGATGCATTAGTAAAAACGATCCGCGAGAGT
GGGAATAAAGAGCATGCTAAAGAACGGATTATTGAATCTTTTGGTTTTACCGAACCTCAAGCTCTTGCGATTTTAGAACT
GCGTTTATATCAACTTACTGGTTTAGAAGCTGAAAAGATTCAAAAAGAGTACGAAGAGTTATTAAATAAGATAGCTTATT
ATAAACAAGTTTTATCGGATGAAGGTTTAGTAAAAGATATCATCAGAAATGAGTTACAAGATCTTTTGAAGCATCATAAG
GTAGCTCGACGCACTACTATAGAATTCGATGCTGATGATATTCGTGATATTGAAGACATCATTACCAATGAGTCTGTTAT
TATCACGATATCCGGAGATGATTACGTAAAGAGAATGCCTGTAAAAGTGTTCAAAGAACAACGTCGTGGCGGGCATGGAG
TTACGGGATTTGATATGAAGAAGGGAGCAGGGTTCCTTAAAGCTGTATACTCTGCCTTTACTAAAGACTATCTCTTAATC
TTCACCAATTTTGGCCAATGTTATTGGTTGAAGGTATGGCAGCTCCCAGAAGGGGAGCGGAGGGCGAAAGGTAAGCCCAT
CATCAACTTCCTAGAGGGAATTCGTCCTGGTGAGGAGCTCGCAGCTATATTGAATATTAAGAATTTTGATAATGCCGGCT
TCTTATTTTTAGCCACCAAACGTGGTGTTGTGAAAAAAGTTTCCTTAGACGCCTTTAGCAACCCTAGGAAAAAGGGAATA
CGTGCTTTAGAGATAGATGAGGGAGACGAACTCATAGCAGCTTGTCACATTGTTAGTGATGAAGAGAAGGTAATGTTATT
TACTCATCTTGGTATGGCAGTTCGCTTCCCCCATGAAAAAGTTCGTCCTATGGGTAGAACTGCACGTGGGGTTCGCGGTG
TCTCTTTGAAAAATGAAGAAGATAAAGTTGTCAGTTGTCAAATTGTGACTGAGAACCAGTCGGTTTTAATTGTATGTGAT
CAAGGTTTTGGTAAGAGATCTTTAGTTGAAGATTTCCGCGAAACCAATCGTGGAGGCGTGGGCGTACGTTCTATCCTTAT
CAATGAAAGAAACGGCAATGTCCTAGGAGCTATTCCTGTTACGGATCACGACAGTATTTTATTAATGTCGAGTCAGGGAC
AGGCAATTCGCATTAACATGCAAGATGTTAGAGTGATGGGAAGATCGACTCAAGGGGTGCGTTTAGTTCACTTGAAAGAA
GGGGATGCTCTTGTTTCTATGGAAAAACTCTCTTCTAATGAAAATGATGATGAAGTACTATCAGGGTCCGAAGAAGAATG
TTCTGATACAGTAAGCCTAAGGTAG

Upstream 100 bases:

>100_bases
GTTGATGGGGGAAGAAGTCCCTCCAAGAAGAGAATTCATAGAAAGTCATGCTTTGTCCATTAGGATAAATAATTTAGATA
TTTAGGAGTCCACAATCCCT

Downstream 100 bases:

>100_bases
TATTGTGTTTATCGTGATTGAGGGGGGCGAAGGGTCTGGCAAAAGTTCTTTAGCAAAGGCTTTAGGAGATCAGCTAGTAG
CTCAAGATCGGAAGGTTTTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 834; Mature: 834

Protein sequence:

>834_residues
MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKI
KVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRES
GNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHK
VARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKKGAGFLKAVYSAFTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGI
RALEIDEGDELIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCD
QGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKE
GDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR

Sequences:

>Translated_834_residues
MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKI
KVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRES
GNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHK
VARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKKGAGFLKAVYSAFTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGI
RALEIDEGDELIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCD
QGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKE
GDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR
>Mature_834_residues
MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKI
KVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRES
GNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHK
VARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKKGAGFLKAVYSAFTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGI
RALEIDEGDELIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCD
QGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKE
GDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=24.9211356466877, Blast_Score=76, Evalue=2e-13,
Organism=Homo sapiens, GI19913406, Length=316, Percent_Identity=24.6835443037975, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788562, Length=861, Percent_Identity=44.7154471544715, Blast_Score=718, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=34.3612334801762, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI212645845, Length=455, Percent_Identity=22.8571428571429, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=343, Percent_Identity=26.2390670553936, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=25.5494505494505, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93810; Mature: 93810

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCC
AKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAM
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCCCHHH
RYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKI
CCCCCCHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHCCCCCEE
KVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDG
EEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
IRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKE
EEEEEEEECCCCCHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
ALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMK
HHHHEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEEL
CCCHHHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDELIAACHIVSD
HHHHEECCCCCCCEEEEEECCCCEEEEEHHHCCCCHHHCCEEEEECCCCCEEEEEEEECC
EEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCD
CCCEEEEEECCCEEECCHHHHCCCCCHHCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEC
QGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINM
CCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEECCCCCEEEEEH
QDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR
HHHHEECCCCCCEEEEEEECCCCEEEHHHHCCCCCCHHHHCCCHHHHCCCCCCC
>Mature Secondary Structure
MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCC
AKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAM
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCCCHHH
RYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKI
CCCCCCHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCCCCCEEECCCCCHHHHCCCCCEE
KVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDG
EEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
IRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKE
EEEEEEEECCCCCHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
ALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMK
HHHHEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEEL
CCCHHHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDELIAACHIVSD
HHHHEECCCCCCCEEEEEECCCCEEEEEHHHCCCCHHHCCEEEEECCCCCEEEEEEEECC
EEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCD
CCCEEEEEECCCEEECCHHHHCCCCCHHCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEC
QGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINM
CCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEECCCCCEEEEEH
QDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR
HHHHEECCCCCCEEEEEEECCCCEEEHHHHCCCCCCHHHHCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]