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The map label for this gene is hemL

Identifier: 15618062

GI number: 15618062

Start: 172697

End: 174019

Strand: Reverse

Name: hemL

Synonym: CPn0138

Alternate gene names: 15618062

Gene position: 174019-172697 (Counterclockwise)

Preceding gene: 15618063

Following gene: 15618061

Centisome position: 14.15

GC content: 43.39

Gene sequence:

>1323_bases
ATGTTGAACTGCTCAAATCAAAAGCATACCGTTACTTTTGAAGAGGCATGCCAAGTCTTCCCAGGAGGCGTGAACTCTCC
CGTTCGGGCCTGCCGTTCTGTAGGAGTCACACCCCCTATAGTGAGCTCAGCACAAGGAGATATTTTCCTAGATACTCACG
GACGAGAGTTTATTGATTTTTGTGGAGGCTGGGGAGCTTTAATTCACGGCCACAGTCATCCCAAAATTGTCAAGGCTATC
CAAAAAACAGCTCTAAAAGGAACCTCCTATGGCTTAACCTCTGAAGAGGAAATTCTATTTGCAACAATGCTCCTCTCCTC
GCTCAAACTCAAAGAACATAAAATCCGTTTTGTATCCTCGGGAACGGAAGCAACAATGACTGCAGTACGTCTCGCTCGAG
GAATCACAAACCGCTCTATTATTATCAAATTTATAGGGGGATATCACGGTCATGCAGATACTCTTCTTGGAGGCATCTCA
ACAACTGAAGAAACTATAGACAACCTAACTTCATTGATACACACGCCCTCTCCACATTCTTTATTGATATCCCTGCCTTA
TAACAATAGCCAAATCCTACACCATGTCATGGAAGCTCTAGGACCTCAAGTAGCAGGAATTATCTTTGAACCTATATGTG
CAAATATGGGTATCGTCCTTCCCAAAGCCGAATTTCTAGACGATATCATAGAACTCTGCAAACGCTTCGGAAGTCTTTCT
ATTATGGATGAAGTCGTCACAGGATTTCGAGTGGCATTCCAAGGAGCTCAAGATATTTTCAATCTCTCCCCCGATATTAC
CATCTATGGAAAAATCTTAGGAGGAGGCCTACCTGCTGCAGCCCTTGTAGGACACCGCTCAATTCTCGATCACCTCATGC
CCGAAGGCACCATATTCCAAGCAGGTACCATGTCTGGGAACTTCCTCGCTATGGCTACAGGACACGCCGCCATTCAATTA
TGCCAATCCGAAGGATTCTATGACCATCTCAGCCAATTAGAGGCTCTCTTTTATTCTCCAATTGAAGAGGAAATCCGATC
TCAAGGATTCCCAGTATCTCTAGTACATCAGGGAACGATGTTCAGCCTCTTTTTTACAGAATCTGCACCCACAAATTTTG
ATGAAGCAAAAAATTCCGATGTAGAGAAATTTCAAACCTTCTACTCTGAAGTATTTGATAATGGAGTCTACCTTTCTCCA
TCTCCCCTCGAAGCAAACTTCATTAGCTCCGCACATACCGAAGAAAACCTAACTTACGCACAGAACATCATTATCGATAG
CCTGATTAAAATCTTTGACTCTTCGGCTCAAAGATTTTTCTAA

Upstream 100 bases:

>100_bases
ACAGTCCCTGACAATCTATTGCTAAACTAACTCACGGCTTTTTCTAGCCATTAAAGATCAGCTTCTCCAAAATATGTGGA
AACTCACTAAAAGAAATTCC

Downstream 100 bases:

>100_bases
TAGTCTCTGCTTTTCACATGCCAGGGCTCATCTTCATACTCTTTCTGAAAATTAGATAGAGATGATAAAACTTAATACGT
TGGAAAAAATCTCATCTGCG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MLNCSNQKHTVTFEEACQVFPGGVNSPVRACRSVGVTPPIVSSAQGDIFLDTHGREFIDFCGGWGALIHGHSHPKIVKAI
QKTALKGTSYGLTSEEEILFATMLLSSLKLKEHKIRFVSSGTEATMTAVRLARGITNRSIIIKFIGGYHGHADTLLGGIS
TTEETIDNLTSLIHTPSPHSLLISLPYNNSQILHHVMEALGPQVAGIIFEPICANMGIVLPKAEFLDDIIELCKRFGSLS
IMDEVVTGFRVAFQGAQDIFNLSPDITIYGKILGGGLPAAALVGHRSILDHLMPEGTIFQAGTMSGNFLAMATGHAAIQL
CQSEGFYDHLSQLEALFYSPIEEEIRSQGFPVSLVHQGTMFSLFFTESAPTNFDEAKNSDVEKFQTFYSEVFDNGVYLSP
SPLEANFISSAHTEENLTYAQNIIIDSLIKIFDSSAQRFF

Sequences:

>Translated_440_residues
MLNCSNQKHTVTFEEACQVFPGGVNSPVRACRSVGVTPPIVSSAQGDIFLDTHGREFIDFCGGWGALIHGHSHPKIVKAI
QKTALKGTSYGLTSEEEILFATMLLSSLKLKEHKIRFVSSGTEATMTAVRLARGITNRSIIIKFIGGYHGHADTLLGGIS
TTEETIDNLTSLIHTPSPHSLLISLPYNNSQILHHVMEALGPQVAGIIFEPICANMGIVLPKAEFLDDIIELCKRFGSLS
IMDEVVTGFRVAFQGAQDIFNLSPDITIYGKILGGGLPAAALVGHRSILDHLMPEGTIFQAGTMSGNFLAMATGHAAIQL
CQSEGFYDHLSQLEALFYSPIEEEIRSQGFPVSLVHQGTMFSLFFTESAPTNFDEAKNSDVEKFQTFYSEVFDNGVYLSP
SPLEANFISSAHTEENLTYAQNIIIDSLIKIFDSSAQRFF
>Mature_440_residues
MLNCSNQKHTVTFEEACQVFPGGVNSPVRACRSVGVTPPIVSSAQGDIFLDTHGREFIDFCGGWGALIHGHSHPKIVKAI
QKTALKGTSYGLTSEEEILFATMLLSSLKLKEHKIRFVSSGTEATMTAVRLARGITNRSIIIKFIGGYHGHADTLLGGIS
TTEETIDNLTSLIHTPSPHSLLISLPYNNSQILHHVMEALGPQVAGIIFEPICANMGIVLPKAEFLDDIIELCKRFGSLS
IMDEVVTGFRVAFQGAQDIFNLSPDITIYGKILGGGLPAAALVGHRSILDHLMPEGTIFQAGTMSGNFLAMATGHAAIQL
CQSEGFYDHLSQLEALFYSPIEEEIRSQGFPVSLVHQGTMFSLFFTESAPTNFDEAKNSDVEKFQTFYSEVFDNGVYLSP
SPLEANFISSAHTEENLTYAQNIIIDSLIKIFDSSAQRFF

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=306, Percent_Identity=29.0849673202614, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=324, Percent_Identity=24.6913580246914, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=30.0884955752212, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786349, Length=421, Percent_Identity=40.6175771971496, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1787560, Length=314, Percent_Identity=30.5732484076433, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI145693181, Length=328, Percent_Identity=29.2682926829268, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789016, Length=314, Percent_Identity=27.0700636942675, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789759, Length=333, Percent_Identity=27.6276276276276, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788044, Length=310, Percent_Identity=28.7096774193548, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786991, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=325, Percent_Identity=25.8461538461538, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=363, Percent_Identity=26.9972451790634, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144274, Length=161, Percent_Identity=29.8136645962733, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=347, Percent_Identity=26.5129682997118, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=326, Percent_Identity=24.5398773006135, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47956; Mature: 47956

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNCSNQKHTVTFEEACQVFPGGVNSPVRACRSVGVTPPIVSSAQGDIFLDTHGREFIDF
CCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHH
CGGWGALIHGHSHPKIVKAIQKTALKGTSYGLTSEEEILFATMLLSSLKLKEHKIRFVSS
HCCCHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
GTEATMTAVRLARGITNRSIIIKFIGGYHGHADTLLGGISTTEETIDNLTSLIHTPSPHS
CCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCE
LLISLPYNNSQILHHVMEALGPQVAGIIFEPICANMGIVLPKAEFLDDIIELCKRFGSLS
EEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCHH
IMDEVVTGFRVAFQGAQDIFNLSPDITIYGKILGGGLPAAALVGHRSILDHLMPEGTIFQ
HHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
AGTMSGNFLAMATGHAAIQLCQSEGFYDHLSQLEALFYSPIEEEIRSQGFPVSLVHQGTM
CCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCE
FSLFFTESAPTNFDEAKNSDVEKFQTFYSEVFDNGVYLSPSPLEANFISSAHTEENLTYA
EEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCCCCHHHH
QNIIIDSLIKIFDSSAQRFF
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNCSNQKHTVTFEEACQVFPGGVNSPVRACRSVGVTPPIVSSAQGDIFLDTHGREFIDF
CCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHH
CGGWGALIHGHSHPKIVKAIQKTALKGTSYGLTSEEEILFATMLLSSLKLKEHKIRFVSS
HCCCHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
GTEATMTAVRLARGITNRSIIIKFIGGYHGHADTLLGGISTTEETIDNLTSLIHTPSPHS
CCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCE
LLISLPYNNSQILHHVMEALGPQVAGIIFEPICANMGIVLPKAEFLDDIIELCKRFGSLS
EEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCCHH
IMDEVVTGFRVAFQGAQDIFNLSPDITIYGKILGGGLPAAALVGHRSILDHLMPEGTIFQ
HHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
AGTMSGNFLAMATGHAAIQLCQSEGFYDHLSQLEALFYSPIEEEIRSQGFPVSLVHQGTM
CCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCE
FSLFFTESAPTNFDEAKNSDVEKFQTFYSEVFDNGVYLSPSPLEANFISSAHTEENLTYA
EEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCCCCHHHH
QNIIIDSLIKIFDSSAQRFF
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]