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The map label for this gene is napA3 [H]

Identifier: 15607010

GI number: 15607010

Start: 1427260

End: 1428528

Strand: Direct

Name: napA3 [H]

Synonym: aq_2030

Alternate gene names: 15607010

Gene position: 1427260-1428528 (Clockwise)

Preceding gene: 15607009

Following gene: 15607012

Centisome position: 92.0

GC content: 42.08

Gene sequence:

>1269_bases
ATGGAACATCATTTGCACCACATAATTCAAGAAACAGCTCCTTACTTAGTCCTTTTATTTATGTTCATTTTCGGTTACAC
ATTCCAGAAGGTAAACATTCCCTCCATTATAGCCTTTATGATTATTGGTTTTTTAGCCCAGCCTTTAGTCCCTCCTGAAA
AAATAAAAGACTTTGAAATATTCAAACACGCCGGGATAATACTGCTTTTCTTCTTCATTGGTCTTGAGTACTCCTTTGAG
AGACTCAGGACTATGCTAGGTGCCTGGAAAACGGGCAGCATTGACTTCGTATTTAACTTTATACCGCCCTTTATAATCGC
CTACGCTTTCGGGTTTGACCTGATCACCGCCCTCATTCTCGCAGCAGTGTTTTACCCTTCCAGCACTTCCATAATCGCAA
AACTTTTAATGGATTACAAACGTATAGCCAGCCCTGAGGCGGAATTGCTCATCGGTATTCTCATATTTGAGGATCTCGTT
GCCATACTCCTGCTAACGATAATTATCCCTCTTAAAGAAGCGGGTAGTATAGAGTTTACAACTATTCCCGTAAGTCTCGT
AAAACTCGGTGTAGCCTTCCTATTATTCTGGCTAATATACAAGTACCTCATTCCCAAGATAAACGCGTGGCTCGACAGAG
TTTCTGAGGAAGATATATTCATATTCTTCACCCTCGGTTTAGTACTGAGCATTGGAACTATCTTTCATTCTCTTGGCATT
TCCGAAGCGCTCGGAGCTTTTCTCCTAGGTGTCATCGTCCCCGAAACAAAAGTTCTTGAAAATATAGAAAAGCAACTTTC
GGACTTAAAGGAACTTTCAATGGGACTGTTTTTCTTCTTCTTCGCTTATGAGACCCAGTTAACGAAGCCCGAAAACTTAG
GTCTGCTAATACTCCTTATAGTTCTCGGAATAATTCTCAAGATCATTTCTACTTACCTTGCTGGTTACGTTTTCGGCTTG
AAGAAAAAGTCGAGACTCAGGGCTTCCCTCTCCTTCGTTCCGAGAGGTGAGTTCTCAGTAATAATGACTTCTTTCGAACC
AGCTTTAAAATCCACTTCCATACCCTTCATATTCTTAACCGCGGTAATTGGAAGTATCCTCTTTGCATTGGCTCCGAAGG
TGGCGGATATCATCTACCCGCCTAAGAAGAAAAAGAAGAAGAAACCGATCAAGCGTCCGAAGAAAGGTTATTTAAAACGC
TCTCGAGCCTTTTCCGAGCACGCTCCAAGTCTTCAGTCTTCCCGACCCGAAACTCCTCCCCAACAATAA

Upstream 100 bases:

>100_bases
TACAAGGAAAAGATACAGGCAGGAGACACTTTAATAGTCGTGGGAACGAGGGAGCAGCTCATCAAGTTCTTAGAAATGTG
CGGAGACTGCAGTACCTGAA

Downstream 100 bases:

>100_bases
CCTCTCCTCTTGTAAAGGGGTAAGGGATTACGAGACCGTCCCATGTATTTAACCTTATAAACTTCTCAAACTTTACCACC
GCAGGTATTATGGGGCTTTC

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEIFKHAGIILLFFFIGLEYSFE
RLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALILAAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLV
AILLLTIIIPLKEAGSIEFTTIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGI
SEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLIVLGIILKIISTYLAGYVFGL
KKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLTAVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKR
SRAFSEHAPSLQSSRPETPPQQ

Sequences:

>Translated_422_residues
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEIFKHAGIILLFFFIGLEYSFE
RLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALILAAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLV
AILLLTIIIPLKEAGSIEFTTIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGI
SEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLIVLGIILKIISTYLAGYVFGL
KKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLTAVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKR
SRAFSEHAPSLQSSRPETPPQQ
>Mature_422_residues
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEIFKHAGIILLFFFIGLEYSFE
RLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALILAAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLV
AILLLTIIIPLKEAGSIEFTTIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGI
SEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLIVLGIILKIISTYLAGYVFGL
KKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLTAVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKR
SRAFSEHAPSLQSSRPETPPQQ

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=368, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786232, Length=307, Percent_Identity=24.7557003257329, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789749, Length=328, Percent_Identity=23.1707317073171, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 47615; Mature: 47615

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FKHAGIILLFFFIGLEYSFERLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLVAILLLTIIIPLKEAGSIEFT
HHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCH
SEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VLGIILKIISTYLAGYVFGLKKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHCCCCHHHHHH
AVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKRSRAFSEHAPSLQSSRPETPP
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
QQ
CC
>Mature Secondary Structure
MEHHLHHIIQETAPYLVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQPLVPPEKIKDFEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FKHAGIILLFFFIGLEYSFERLRTMLGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFYPSSTSIIAKLLMDYKRIASPEAELLIGILIFEDLVAILLLTIIIPLKEAGSIEFT
HHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TIPVSLVKLGVAFLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCH
SEALGAFLLGVIVPETKVLENIEKQLSDLKELSMGLFFFFFAYETQLTKPENLGLLILLI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VLGIILKIISTYLAGYVFGLKKKSRLRASLSFVPRGEFSVIMTSFEPALKSTSIPFIFLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHCCCCHHHHHH
AVIGSILFALAPKVADIIYPPKKKKKKKPIKRPKKGYLKRSRAFSEHAPSLQSSRPETPP
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
QQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]