| Definition | Aquifex aeolicus VF5, complete genome. |
|---|---|
| Accession | NC_000918 |
| Length | 1,551,335 |
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The map label for this gene is trxA1 [H]
Identifier: 15606934
GI number: 15606934
Start: 1348671
End: 1349090
Strand: Direct
Name: trxA1 [H]
Synonym: aq_1916
Alternate gene names: 15606934
Gene position: 1348671-1349090 (Clockwise)
Preceding gene: 15606933
Following gene: 15606935
Centisome position: 86.94
GC content: 44.52
Gene sequence:
>420_bases ATGGCAGGTAGAGTAATTGAACTTAACGAACAAAATTGGGAACAAGAAGTTCTCCAGTCCGATAAACCTGTTCTCGTTGA CTTTTGGGCACCATGGTGCGGACCATGCAGGATAATAGCTCCCATAATTGAAGAAATTGCGGAAGAACTGGGAGACAAAG TAAAGGTAGGAAAGCTCAACACCGACGAAAATCCCAACATAGCAATGAGGTACGGCATCAGGGCTATACCCACGATAATC CTCTTCAAAAATGGGGAGGTGGTGGATACAAGAATAGGTGTCCAACCAAAAGAACGATTAAACAAATGGTTCTTGAGCAC GTTTAATAATTTATGGAGGCTCAGGCCGGTTTTGATACCTTTATTGAAGCCACACGTTACCTCTTTCGGGGGCCCTCCCC CCAGGAAATCCTTCTCTTAA
Upstream 100 bases:
>100_bases GGCATAGTAGGTTGGAAGAGAGAAGGCTCGATTATATGCTACTATATTAAAGACGACAGGGTTAAGAAAATCTACGAATT AATTGTAAAGGAGGAAGAAC
Downstream 100 bases:
>100_bases TAATCGTCCTTGGCGCATTAATCACGGTAGTTTCCCTGCCTTTTTTTTACTCAAAACTTAAAGAAAAGCAAAGGATAAGA GAGAACTTTTTTCGCAGGGC
Product: thioredoxin
Products: NA
Alternate protein names: Trx-1; Thioredoxin-M [H]
Number of amino acids: Translated: 139; Mature: 138
Protein sequence:
>139_residues MAGRVIELNEQNWEQEVLQSDKPVLVDFWAPWCGPCRIIAPIIEEIAEELGDKVKVGKLNTDENPNIAMRYGIRAIPTII LFKNGEVVDTRIGVQPKERLNKWFLSTFNNLWRLRPVLIPLLKPHVTSFGGPPPRKSFS
Sequences:
>Translated_139_residues MAGRVIELNEQNWEQEVLQSDKPVLVDFWAPWCGPCRIIAPIIEEIAEELGDKVKVGKLNTDENPNIAMRYGIRAIPTII LFKNGEVVDTRIGVQPKERLNKWFLSTFNNLWRLRPVLIPLLKPHVTSFGGPPPRKSFS >Mature_138_residues AGRVIELNEQNWEQEVLQSDKPVLVDFWAPWCGPCRIIAPIIEEIAEELGDKVKVGKLNTDENPNIAMRYGIRAIPTIIL FKNGEVVDTRIGVQPKERLNKWFLSTFNNLWRLRPVLIPLLKPHVTSFGGPPPRKSFS
Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]
COG id: COG0526
COG function: function code OC; Thiol-disulfide isomerase and thioredoxins
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 thioredoxin domain [H]
Homologues:
Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=35.4838709677419, Blast_Score=87, Evalue=6e-18, Organism=Homo sapiens, GI5031973, Length=78, Percent_Identity=43.5897435897436, Blast_Score=75, Evalue=2e-14, Organism=Homo sapiens, GI20070125, Length=97, Percent_Identity=36.0824742268041, Blast_Score=69, Evalue=1e-12, Organism=Homo sapiens, GI224493972, Length=107, Percent_Identity=29.9065420560748, Blast_Score=67, Evalue=4e-12, Organism=Homo sapiens, GI24308127, Length=76, Percent_Identity=38.1578947368421, Blast_Score=67, Evalue=7e-12, Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=2e-11, Organism=Homo sapiens, GI42794771, Length=107, Percent_Identity=29.9065420560748, Blast_Score=64, Evalue=4e-11, Organism=Homo sapiens, GI4758304, Length=88, Percent_Identity=38.6363636363636, Blast_Score=63, Evalue=9e-11, Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=50, Blast_Score=124, Evalue=2e-30, Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=47.0588235294118, Blast_Score=103, Evalue=3e-24, Organism=Escherichia coli, GI87081747, Length=95, Percent_Identity=38.9473684210526, Blast_Score=73, Evalue=9e-15, Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=40.8602150537634, Blast_Score=86, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=41.9753086419753, Blast_Score=77, Evalue=2e-15, Organism=Caenorhabditis elegans, GI115532380, Length=96, Percent_Identity=39.5833333333333, Blast_Score=70, Evalue=3e-13, Organism=Caenorhabditis elegans, GI115532378, Length=96, Percent_Identity=39.5833333333333, Blast_Score=70, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=39.0243902439024, Blast_Score=69, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17544108, Length=96, Percent_Identity=39.5833333333333, Blast_Score=68, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17549970, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17554386, Length=85, Percent_Identity=38.8235294117647, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI25144092, Length=88, Percent_Identity=35.2272727272727, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI193209454, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=4e-12, Organism=Caenorhabditis elegans, GI71998175, Length=65, Percent_Identity=46.1538461538462, Blast_Score=66, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17569137, Length=85, Percent_Identity=36.4705882352941, Blast_Score=66, Evalue=6e-12, Organism=Caenorhabditis elegans, GI32566189, Length=85, Percent_Identity=36.4705882352941, Blast_Score=66, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17511147, Length=79, Percent_Identity=37.9746835443038, Blast_Score=65, Evalue=8e-12, Organism=Caenorhabditis elegans, GI71980562, Length=94, Percent_Identity=31.9148936170213, Blast_Score=65, Evalue=9e-12, Organism=Caenorhabditis elegans, GI71980565, Length=100, Percent_Identity=32, Blast_Score=65, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=37.5, Blast_Score=79, Evalue=4e-16, Organism=Saccharomyces cerevisiae, GI6323072, Length=80, Percent_Identity=42.5, Blast_Score=76, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=34.0909090909091, Blast_Score=65, Evalue=3e-12, Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=37.2340425531915, Blast_Score=92, Evalue=9e-20, Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=41.8604651162791, Blast_Score=88, Evalue=2e-18, Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=42.3076923076923, Blast_Score=75, Evalue=1e-14, Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=42.3076923076923, Blast_Score=75, Evalue=1e-14, Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=45.679012345679, Blast_Score=74, Evalue=4e-14, Organism=Drosophila melanogaster, GI21358065, Length=97, Percent_Identity=31.9587628865979, Blast_Score=72, Evalue=8e-14, Organism=Drosophila melanogaster, GI24639068, Length=86, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=9e-13, Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12, Organism=Drosophila melanogaster, GI20130317, Length=91, Percent_Identity=36.2637362637363, Blast_Score=63, Evalue=5e-11,
Paralogues:
None
Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005746 - InterPro: IPR017936 - InterPro: IPR012336 - InterPro: IPR017937 - InterPro: IPR013766 - InterPro: IPR012335 [H]
Pfam domain/function: PF00085 Thioredoxin [H]
EC number: NA
Molecular weight: Translated: 15872; Mature: 15741
Theoretical pI: Translated: 8.76; Mature: 8.76
Prosite motif: PS00194 THIOREDOXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAGRVIELNEQNWEQEVLQSDKPVLVDFWAPWCGPCRIIAPIIEEIAEELGDKVKVGKLN CCCCEEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC TDENPNIAMRYGIRAIPTIILFKNGEVVDTRIGVQPKERLNKWFLSTFNNLWRLRPVLIP CCCCCCEEEECCHHHHCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH LLKPHVTSFGGPPPRKSFS HHHHHHHCCCCCCCCCCCC >Mature Secondary Structure AGRVIELNEQNWEQEVLQSDKPVLVDFWAPWCGPCRIIAPIIEEIAEELGDKVKVGKLN CCCEEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC TDENPNIAMRYGIRAIPTIILFKNGEVVDTRIGVQPKERLNKWFLSTFNNLWRLRPVLIP CCCCCCEEEECCHHHHCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH LLKPHVTSFGGPPPRKSFS HHHHHHHCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2492995 [H]