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The map label for this gene is nadA

Identifier: 15606917

GI number: 15606917

Start: 1331127

End: 1332095

Strand: Direct

Name: nadA

Synonym: aq_1889

Alternate gene names: 15606917

Gene position: 1331127-1332095 (Clockwise)

Preceding gene: 15606915

Following gene: 15606921

Centisome position: 85.81

GC content: 45.1

Gene sequence:

>969_bases
ATGGTACAGCTCGCCTTAAAGGAGGAGAAAGAACTTACTAAGGAGGAGATAAAGGAACTCCAGAAAGAAGTTAGGAGACT
CGCAAAGGAAAAGAACGCTGTAATACTCGCTCACTATTATCAGAGACCGGAGGTTCAAGATATAGCGGATTTTGTAGGAG
ATTCTTTAGAGCTCGCCAGAAAGGCTTCTCAGACGGACGCGGACATTATTGTATTCTGCGGTGTTAGGTTTATGTGTGAA
ACCGCAAAGATAGTAAATCCCGAGAAAAAGGTTCTCCACCCAAATCCGGAAAGCGGATGCCCCATGGCAGACATGATAAC
GGCAAAGCAAGTAAGGGAACTCAGGGAAAAGCATCCGGACGCGGAATTCGTAGCCTACATAAACACCACCGCGGACGTTA
AGGCGGAAGTGGACATATGCGTAACCTCCGCAAACGCCCCAAAAATAATAAAGAAACTCGAAGCTAAAAAGATCGTATTC
CTACCGGATCAAGCTCTCGGTAACTGGGTGGCAAAGCAAGTTCCGGAAAAGGAATTCATAATATGGAAAGGTTTCTGTCC
TCCACACTTTGAGTTTACGTACAAGGAACTCGAAAAGTTAAAGGAAATGTACCCCGACGCCAAGGTGGCAGTTCACCCAG
AGTGCCACCCCAGAGTCATAGAACTTGCGGACTTCGTAGGATCTACTTCCCAGATACTCAAGTACGCCACAAGTGTTGAT
GCAAAAAGGGTAATAGTGGTAACCGAAGTTGGACTCAAGTACACACTGGAAAAGATTAATCCGAATAAGGAATACATTTT
CCCCCAATCCATGAATTACTGCGGAACCGTTTACTGTTGTACAATGAAGGGAATTACGCTACCTAAAGTTTACGAGACCT
TAAAGAACGAAATAAACGAAGTGACGCTTCCCAAAGATATTATAGAGAGGGCGAGGAGACCCATAGAGAGGATGCTCGAG
CTCAGTTAA

Upstream 100 bases:

>100_bases
TAACGCGGTTTTAAAAAGCTTGTGATAAAAAGCAATGATTTAGCCAAGTGGACAAAAATCTTACAGCGCCTATTTAATAA
ATTCTTAACGGAGGTGATGA

Downstream 100 bases:

>100_bases
AGTATCTTCTTTGCGGTTTCCCACATGGCTATAGCACCGGCGGACCCGACATTTAACGAAGTTACTTTCCCCTTCATTGG
TATGGTTACGATTTGGTCCG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVQLALKEEKELTKEEIKELQKEVRRLAKEKNAVILAHYYQRPEVQDIADFVGDSLELARKASQTDADIIVFCGVRFMCE
TAKIVNPEKKVLHPNPESGCPMADMITAKQVRELREKHPDAEFVAYINTTADVKAEVDICVTSANAPKIIKKLEAKKIVF
LPDQALGNWVAKQVPEKEFIIWKGFCPPHFEFTYKELEKLKEMYPDAKVAVHPECHPRVIELADFVGSTSQILKYATSVD
AKRVIVVTEVGLKYTLEKINPNKEYIFPQSMNYCGTVYCCTMKGITLPKVYETLKNEINEVTLPKDIIERARRPIERMLE
LS

Sequences:

>Translated_322_residues
MVQLALKEEKELTKEEIKELQKEVRRLAKEKNAVILAHYYQRPEVQDIADFVGDSLELARKASQTDADIIVFCGVRFMCE
TAKIVNPEKKVLHPNPESGCPMADMITAKQVRELREKHPDAEFVAYINTTADVKAEVDICVTSANAPKIIKKLEAKKIVF
LPDQALGNWVAKQVPEKEFIIWKGFCPPHFEFTYKELEKLKEMYPDAKVAVHPECHPRVIELADFVGSTSQILKYATSVD
AKRVIVVTEVGLKYTLEKINPNKEYIFPQSMNYCGTVYCCTMKGITLPKVYETLKNEINEVTLPKDIIERARRPIERMLE
LS
>Mature_322_residues
MVQLALKEEKELTKEEIKELQKEVRRLAKEKNAVILAHYYQRPEVQDIADFVGDSLELARKASQTDADIIVFCGVRFMCE
TAKIVNPEKKVLHPNPESGCPMADMITAKQVRELREKHPDAEFVAYINTTADVKAEVDICVTSANAPKIIKKLEAKKIVF
LPDQALGNWVAKQVPEKEFIIWKGFCPPHFEFTYKELEKLKEMYPDAKVAVHPECHPRVIELADFVGSTSQILKYATSVD
AKRVIVVTEVGLKYTLEKINPNKEYIFPQSMNYCGTVYCCTMKGITLPKVYETLKNEINEVTLPKDIIERARRPIERMLE
LS

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=323, Percent_Identity=36.8421052631579, Blast_Score=205, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_AQUAE (O67730)

Other databases:

- EMBL:   AE000657
- PIR:   H70462
- RefSeq:   NP_214298.1
- ProteinModelPortal:   O67730
- SMR:   O67730
- GeneID:   1193537
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1889
- NMPDR:   fig|224324.1.peg.1313
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- PhylomeDB:   O67730
- ProtClustDB:   PRK09375
- BioCyc:   AAEO224324:AQ_1889-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 36804; Mature: 36804

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: BINDING 38-38 BINDING 55-55 BINDING 126-126 BINDING 143-143 BINDING 212-212 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQLALKEEKELTKEEIKELQKEVRRLAKEKNAVILAHYYQRPEVQDIADFVGDSLELAR
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCHHHHHH
KASQTDADIIVFCGVRFMCETAKIVNPEKKVLHPNPESGCPMADMITAKQVRELREKHPD
HCCCCCCCEEEECCHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
AEFVAYINTTADVKAEVDICVTSANAPKIIKKLEAKKIVFLPDQALGNWVAKQVPEKEFI
CEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCEE
IWKGFCPPHFEFTYKELEKLKEMYPDAKVAVHPECHPRVIELADFVGSTSQILKYATSVD
EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCC
AKRVIVVTEVGLKYTLEKINPNKEYIFPQSMNYCGTVYCCTMKGITLPKVYETLKNEINE
CCEEEEEEECCCEEEHHHCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHC
VTLPKDIIERARRPIERMLELS
CCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVQLALKEEKELTKEEIKELQKEVRRLAKEKNAVILAHYYQRPEVQDIADFVGDSLELAR
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCHHHHHH
KASQTDADIIVFCGVRFMCETAKIVNPEKKVLHPNPESGCPMADMITAKQVRELREKHPD
HCCCCCCCEEEECCHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
AEFVAYINTTADVKAEVDICVTSANAPKIIKKLEAKKIVFLPDQALGNWVAKQVPEKEFI
CEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCEE
IWKGFCPPHFEFTYKELEKLKEMYPDAKVAVHPECHPRVIELADFVGSTSQILKYATSVD
EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCC
AKRVIVVTEVGLKYTLEKINPNKEYIFPQSMNYCGTVYCCTMKGITLPKVYETLKNEINE
CCEEEEEEECCCEEEHHHCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHC
VTLPKDIIERARRPIERMLELS
CCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320