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The map label for this gene is cysM

Identifier: 15606692

GI number: 15606692

Start: 1100086

End: 1101069

Strand: Direct

Name: cysM

Synonym: aq_1556

Alternate gene names: 15606692

Gene position: 1100086-1101069 (Clockwise)

Preceding gene: 15606684

Following gene: 15606693

Centisome position: 70.91

GC content: 46.14

Gene sequence:

>984_bases
TTGTCGTTAAAATCATGTTTAATGTGGGTTTTGGGTGAACACGACGAGCCTTACAGAAAAGCGCGTGAAACAATACTAAA
ACTCGTAGGAAACACACCCCTCGTAAGAGTAAAAAAGTGTCTTCCAGAAGATATACCCGAGGACGTAGAAATCTGGGCAA
AGTTAGAGAGTTTCAATCCCGGCGGTTCGGTAAAGGACAGACCTGCTCTCAGTATGTTTCTGGACGCCTTAAAAAGGGGG
CTTATTAAAGAGGGAAAAGTTGTAATAGACGCAACTTCCGGAAATACGGGAATAGCCCTCGCCATGGTTGGTGCAGCTCT
CGGCGTTCCCGTGGAACTTGCCATGCCAGCAAACGTAAGTGAAGAGAGGAAGAAGATAATAAAAGCCTTCGGAGCGAAAC
TTTACCTTACCGATCCCCTTGAGGGTACCGATGGAGCTATCCTCTTTGTAAGGGAACTTGTTCAGAAGTACCCTGAAAAG
TACGTGTACCTCGACCAATACAACAATCCAGCAAACTGGAAAGCTCACTTTTACTCTACCGGTATAGAGATATGGAATCA
AACTAAGGGGAGGATAACTCACTTCGTCGCAGGGATAGGAACAGGCGGAACGATAATGGGAACGGGAAGGAGACTAAAGA
TTTACAACCCGAATATTCAAGTAATAGGAGTCCAGCCTGCGTATCCTTTTCACGGAATAGAAGGTTTAAAACACATAGAG
AGTTCAATAAAGCCGGGAATATTTGACGAGACCTTTCTGGACAGGACTATCTTCGTAGAGACGGAAGACGCCTACTACTG
GGCAAGGGAGCTTGCAAAAAAGGACGCTATATTCGTAGGACAGTCATCGGGAGCGGCTCTCTGGGCATGCATTCAACTCG
CAAGGGAACTTGCGAAAAAAGGTGAAAAGGGCGTAATAGTTACCGTTTTTCCGGACGGAGGGGAGAAGTACCTCACCACG
GCTCTTTTCTCTGACAAGGATTAA

Upstream 100 bases:

>100_bases
GTTTTTCTCGTTTCCCTGTTCATTATCCTTTCGAGTCTTATCTCTTTTCCTATTCCCATTTTCTACCTCCGAGACCTTTA
AAATAGTATCATACCGCCCT

Downstream 100 bases:

>100_bases
TAAGTTTTTATTAGAATATCCTACATTATGGGGATAATAAAACTTCTCTTCGGATTCCTGTTCCTGATCTTCGCGGTAGC
CTTCACTTACTACAACCTTC

Product: cysteine synthase, O-acetylserine (thiol) lyase B

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSLKSCLMWVLGEHDEPYRKARETILKLVGNTPLVRVKKCLPEDIPEDVEIWAKLESFNPGGSVKDRPALSMFLDALKRG
LIKEGKVVIDATSGNTGIALAMVGAALGVPVELAMPANVSEERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEK
YVYLDQYNNPANWKAHFYSTGIEIWNQTKGRITHFVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPAYPFHGIEGLKHIE
SSIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAALWACIQLARELAKKGEKGVIVTVFPDGGEKYLTT
ALFSDKD

Sequences:

>Translated_327_residues
MSLKSCLMWVLGEHDEPYRKARETILKLVGNTPLVRVKKCLPEDIPEDVEIWAKLESFNPGGSVKDRPALSMFLDALKRG
LIKEGKVVIDATSGNTGIALAMVGAALGVPVELAMPANVSEERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEK
YVYLDQYNNPANWKAHFYSTGIEIWNQTKGRITHFVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPAYPFHGIEGLKHIE
SSIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAALWACIQLARELAKKGEKGVIVTVFPDGGEKYLTT
ALFSDKD
>Mature_326_residues
SLKSCLMWVLGEHDEPYRKARETILKLVGNTPLVRVKKCLPEDIPEDVEIWAKLESFNPGGSVKDRPALSMFLDALKRGL
IKEGKVVIDATSGNTGIALAMVGAALGVPVELAMPANVSEERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEKY
VYLDQYNNPANWKAHFYSTGIEIWNQTKGRITHFVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPAYPFHGIEGLKHIES
SIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAALWACIQLARELAKKGEKGVIVTVFPDGGEKYLTTA
LFSDKD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family

Homologues:

Organism=Homo sapiens, GI295821202, Length=319, Percent_Identity=33.8557993730408, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI295821200, Length=319, Percent_Identity=33.8557993730408, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI4557415, Length=319, Percent_Identity=33.8557993730408, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=42.2442244224422, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1788754, Length=311, Percent_Identity=40.1929260450161, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=311, Percent_Identity=42.7652733118971, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=42.2077922077922, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=41.8604651162791, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI115535073, Length=314, Percent_Identity=39.4904458598726, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=40.7766990291262, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=40.3669724770642, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17534315, Length=324, Percent_Identity=32.7160493827161, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=32.2085889570552, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321594, Length=329, Percent_Identity=35.5623100303951, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=32.5373134328358, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=35.2564102564103, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=35.2564102564103, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSM_AQUAE (O67507)

Other databases:

- EMBL:   AE000657
- PIR:   A70435
- RefSeq:   NP_214072.1
- ProteinModelPortal:   O67507
- SMR:   O67507
- GeneID:   1193130
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1556
- NMPDR:   fig|224324.1.peg.1087
- HOGENOM:   HBG748215
- OMA:   KHIESSI
- PhylomeDB:   O67507
- ProtClustDB:   CLSK2299750
- BioCyc:   AAEO224324:AQ_1556-MONOMER
- BRENDA:   2.5.1.47
- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926
- TIGRFAMs:   TIGR01136
- TIGRFAMs:   TIGR01138

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =2.5.1.47

Molecular weight: Translated: 36155; Mature: 36024

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: BINDING 95-95 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKSCLMWVLGEHDEPYRKARETILKLVGNTPLVRVKKCLPEDIPEDVEIWAKLESFNP
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCC
GGSVKDRPALSMFLDALKRGLIKEGKVVIDATSGNTGIALAMVGAALGVPVELAMPANVS
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCC
EERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEKYVYLDQYNNPANWKAHFYST
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEC
GIEIWNQTKGRITHFVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPAYPFHGIEGLKHIE
CHHHHCCCCCCEEHHEEECCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHH
SSIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAALWACIQLARELAKK
HHCCCCCCCHHHCCCEEEEEECCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHC
GEKGVIVTVFPDGGEKYLTTALFSDKD
CCCCEEEEEECCCCCCEEEEEECCCCC
>Mature Secondary Structure 
SLKSCLMWVLGEHDEPYRKARETILKLVGNTPLVRVKKCLPEDIPEDVEIWAKLESFNP
CHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCC
GGSVKDRPALSMFLDALKRGLIKEGKVVIDATSGNTGIALAMVGAALGVPVELAMPANVS
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCC
EERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEKYVYLDQYNNPANWKAHFYST
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEC
GIEIWNQTKGRITHFVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPAYPFHGIEGLKHIE
CHHHHCCCCCCEEHHEEECCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHH
SSIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAALWACIQLARELAKK
HHCCCCCCCHHHCCCEEEEEECCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHC
GEKGVIVTVFPDGGEKYLTTALFSDKD
CCCCEEEEEECCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320