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The map label for this gene is icd

Identifier: 15606665

GI number: 15606665

Start: 1076238

End: 1077518

Strand: Direct

Name: icd

Synonym: aq_1512

Alternate gene names: 15606665

Gene position: 1076238-1077518 (Clockwise)

Preceding gene: 15606656

Following gene: 15606666

Centisome position: 69.37

GC content: 48.01

Gene sequence:

>1281_bases
ATGAATAAAACAACGTTTGAAAATGTTTACTACTGGGAAGGAAAGGCACAAATCCCCCAGGAAGGGCAGTTTATAAAGCT
CAAAGAAGATAAAACCTTAGAAGTTCCAGACAACCCGATAATTCCCTTCATAGAGGGAGATGGGATAGGTCCTGAAATAA
CGCAGGCTATGCTCCTTATTATCAACACAGCGGTTGAAAAAACTTACAACGGAAGCAAGAAGATTTACTGGGTAGAACTC
CTCGCGGGGGATAAGGCGGAAGAAAAGACTGGAGAGAGGCTTCCTCAGGAAACCCTGGACGTTTTAAAAGAATCAATAGT
AGGTATAAAAGGACCCCTCGGAACGCCCGTAGGAAAAGGTGTCCGCTCCATAAACTCCGCCCTCAGGAGGGCATTTGATT
ACTACTCTGCGGTAAGACCCGTTTACTGGATGGGCCAGGCAACTCCGATTCCAAATCCTGAGAGGGTTGACCTCGTAGTT
TTCAGAGAAAACACCGACGACGTCTACGCGGGAGTGGAGTTCTTTGCGGGAACGCCCGAAGCCAAAAAGGTAAGAGAATT
CCTCATAAAGGAGATGGGGGCAAAAGAGGAAGGCTTCCCCGAAGATGTGGGAATAACGGTAAAGCCCATGAGCGAGTTCA
AGACAAAGAGACACGTGAGGAAAGCACTCAGATACGCCCTTGAAAACAACAAGAAGAACGTCGCGGTAATAGGAAAAGGA
AACATAATGAAGGCAACGGAAGGGGCCTTCATAAACTGGGCTTTTGAGGTAGCAGAAGAGCCCGAATTCAAAGGAAAGGT
AGTAACGGACCCGGAAGCAGAGCCCGGCGAAGGACAGGTAAAACTCACAAAAGTGATAACCGACCAGATGCTTATGCAAC
TTGTCCTCAAGCCCGAAGCTTGGGACGTGATAATCGCTCAGAACTTGAACGGTGACTACGTTTCCGACCTTGCAGCTTCT
CTGATAGGAGGTCCAGGATTTGTTCCGAGCGGAAACATAGGGGACGGATATGCCCTCTTTGAAAGCACCCACGGAACAGC
TTGGGACATAGCAGGCAAGGGAATAGCAAATCCCCTTTCCCTTACACTATCTGGCGCGATGATGCTTGAATACATAGGCT
GGAAAGAAGCAGCTCAAAAGGTCTACGACGCAGTAAGAAGAACCCTTGCGGAACATATAGGAACGCCCGATATCGCAAGC
GGATTCCAGAAACAGGGAATAGAAGCTAAAGCAGTAGGCACGATGGAGTTCGCCGAAGAAATTTCCAAGAGGATTGAGTA
A

Upstream 100 bases:

>100_bases
ACCTCTAGAGATTTATAACAAAAATCAAAAAGTGTTTTAAATTAACTTGACACACTTCTTCAAAATGAATAAAATTACAC
TCTACTTTCGGAGGAGAGCG

Downstream 100 bases:

>100_bases
TTATTCCCTAACAAGGAGGTCATAAATGAAGGTTAAAGTCAAGCAAAAGGAAGACTTTCACTTCATCGGTGTTGGACCTG
CGGGCAGAGAAGTGCCTATA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVEL
LAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVV
FRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKG
NIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAAS
LIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIAS
GFQKQGIEAKAVGTMEFAEEISKRIE

Sequences:

>Translated_426_residues
MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVEL
LAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVV
FRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKG
NIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAAS
LIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIAS
GFQKQGIEAKAVGTMEFAEEISKRIE
>Mature_426_residues
MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVEL
LAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVV
FRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKG
NIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAAS
LIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIAS
GFQKQGIEAKAVGTMEFAEEISKRIE

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

Homologues:

Organism=Homo sapiens, GI5031777, Length=390, Percent_Identity=33.8461538461538, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4758582, Length=409, Percent_Identity=26.161369193154, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI28178838, Length=381, Percent_Identity=25.9842519685039, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI28178821, Length=349, Percent_Identity=29.512893982808, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI28178816, Length=349, Percent_Identity=29.512893982808, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.0441988950276, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=45.8033573141487, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI87081683, Length=404, Percent_Identity=27.970297029703, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788101, Length=385, Percent_Identity=27.5324675324675, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=353, Percent_Identity=33.9943342776204, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144293, Length=367, Percent_Identity=29.1553133514986, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17505779, Length=360, Percent_Identity=30.2777777777778, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17550882, Length=377, Percent_Identity=25.1989389920424, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322097, Length=369, Percent_Identity=35.5013550135501, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324709, Length=394, Percent_Identity=31.4720812182741, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324291, Length=354, Percent_Identity=31.3559322033898, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24643270, Length=356, Percent_Identity=35.3932584269663, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24643268, Length=356, Percent_Identity=35.1123595505618, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24661184, Length=356, Percent_Identity=32.5842696629214, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161078635, Length=280, Percent_Identity=32.8571428571429, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078633, Length=280, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24650122, Length=280, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078637, Length=280, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI161078639, Length=280, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20130355, Length=360, Percent_Identity=23.8888888888889, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281362242, Length=377, Percent_Identity=25.4641909814324, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648872, Length=377, Percent_Identity=25.4641909814324, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IDH_AQUAE (O67480)

Other databases:

- EMBL:   AE000657
- PIR:   F70431
- RefSeq:   NP_214045.1
- ProteinModelPortal:   O67480
- SMR:   O67480
- GeneID:   1193103
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1512
- NMPDR:   fig|224324.1.peg.1060
- HOGENOM:   HBG518924
- OMA:   RDWGYEL
- PhylomeDB:   O67480
- ProtClustDB:   CLSK2299732
- BioCyc:   AAEO224324:AQ_1512-MONOMER
- BRENDA:   1.1.1.42
- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439
- Gene3D:   G3DSA:3.40.718.10
- PANTHER:   PTHR11835
- PANTHER:   PTHR11835:SF1

Pfam domain/function: PF00180 Iso_dh

EC number: =1.1.1.42

Molecular weight: Translated: 46925; Mature: 46925

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00470 IDH_IMDH

Important sites: BINDING 123-123 BINDING 125-125 BINDING 129-129 BINDING 139-139 BINDING 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLI
CCCCEECCEEEECCCCCCCCCCCEEEECCCCEEECCCCCEEEEEECCCCCHHHHHHHHHH
INTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKG
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHH
VRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPE
HHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCC
AKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKG
HHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
NIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEA
CEEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCC
WDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLS
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCHH
LTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECHHHHHHHH
ISKRIE
HHHHCC
>Mature Secondary Structure
MNKTTFENVYYWEGKAQIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLI
CCCCEECCEEEECCCCCCCCCCCEEEECCCCEEECCCCCEEEEEECCCCCHHHHHHHHHH
INTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLDVLKESIVGIKGPLGTPVGKG
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHH
VRSINSALRRAFDYYSAVRPVYWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPE
HHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCC
AKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKG
HHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
NIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEA
CEEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCC
WDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLS
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCHH
LTLSGAMMLEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECHHHHHHHH
ISKRIE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320