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The map label for this gene is accC2 [H]

Identifier: 15606634

GI number: 15606634

Start: 1047198

End: 1048631

Strand: Direct

Name: accC2 [H]

Synonym: aq_1470

Alternate gene names: 15606634

Gene position: 1047198-1048631 (Clockwise)

Preceding gene: 15606630

Following gene: 15606635

Centisome position: 67.5

GC content: 46.51

Gene sequence:

>1434_bases
ATGTTTAGAAAAGTTCTCGTTGCCAACAGGGGTGAAGTTGCGGTAAGGATAATAAGGGCCTGTAAAGAGCTGGGAATAAA
AACAGTTGCGATATATTCGGAAGCGGATGTGCGTTCCCTCCACGTTAAAAAAGCAGATGAAGCTTACCTCATTACGGGAG
ATCCGATAAGGGCTTACCTTGATTACGTGAGAATAGTTGACCTTGCAAAGCAGGTGGGGGCGGATGCCATTCACCCGGGT
TATGGCTTTTTGGCGGAAAACGCCGACTTTGCGCGTTACTGCAGGAGGAGGGGGATAACTTTTATAGGCCCTACTCCCGA
ACAAATAGAGATGTTCGGAGATAAAGTAAAGGCTAAAAAGGTTATGAAGGAGGTGGGGCTCCCTACAATACCTGGAACGG
AAGAGCCAGTAAGAACTCTTGAAGATGCAAAACACGCCGTTAAGGAGATAGGTTTCCCCGTGATGCTGAAAGCCGCTTAC
GGCGGTGGCGGTAGGGGGATGAGAGTTATTAGAAACGAGGAAGAACTTGAAAAGAACTTCGAGAGCGCGTTCAGGGAAGC
GGAAACCTTCTTCGGAAAAGGAGACCTATTTATAGAAAAGTACGTGGAAAACCCAAAACACATAGAAGTTCAAATCCTCG
GAGATAAGTACGGAAACATAATACACCTAGGAGAAAGAGATTGTTCAATTCAGAGGAGACACCAGAAGTTAATCGAGATA
GCCCCGTCCCCTAAACTCCCTCAGGATCTCAGGATGAAAATCCTCGGAAACGCCGTAAGGGCGATGACAAGAGTAGGATA
CGAAAACGCAGGAACACTTGAGTTTTTGGTGGACCTCAAAACGGGAGAGTATTACTTCATTGAGATGAATACAAGACTTC
AGGTGGAACACACAATTACGGAAGCAATTACGGGAGTGGACATAGTTGAAGCGATGATAAGGATAGCGGCGGGAGAACCT
TTGCCTTACCTCCAAAGCGATATAACTTTCAGGGGATACGCAATAGAGTTCAGGATAAATGCTGAAGATCCTAAGAAAAA
CTTTGCACCTGCACCCGGTAAAATTACCTCTTATTACTCCCCCGGAGGGCCTGGTGTAAGAATAGACGCCTCCGTTTACA
AGGACTACATTATCCCGCCCTACTACGATTCCATGATTGCAAAGATGACAGTATGGGCACTAACATGGGAAAAGGCTGTG
GCAAGGGCAAGGAGAGCACTTGATGAGTTCGTAGTGAGGGGAGTTCCCACGAATATACCCCTCTACAGGGAAATAGTAAG
AGACCCCGACTTCTTAAAGGGAGACTTCGGAACAAGGTTCTTGGAAGAGAAAATAGCGAAGGGAGAGTACGACTTTGAAA
TAGAAGGCGAAAAGCCCATGGAAGACGTAGTTCTTGCAATATCGGCGGCTATAGCAGCCCACTACGGACTTTAA

Upstream 100 bases:

>100_bases
TTATTAGACCCATCATCCCTATTCAGTTGCCAAGGAGCCGGAATAGGGCGAAAAGCCTTTTTTTATAATTATACCTAAAA
AAATTTTAAACTTATTAATT

Downstream 100 bases:

>100_bases
GACTCCTTTTTTGCCCTCCTTTGTTTCTTCTTCTTTTCCTCTTCTTCGGCCATCTTTATCTGTTCTTCAGGGGAAGGATA
CGAAAGTCTTATTTCGCCGT

Product: biotin carboxylase

Products: NA

Alternate protein names: 2-oxoglutarate carboxylase beta subunit [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MFRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLITGDPIRAYLDYVRIVDLAKQVGADAIHPG
YGFLAENADFARYCRRRGITFIGPTPEQIEMFGDKVKAKKVMKEVGLPTIPGTEEPVRTLEDAKHAVKEIGFPVMLKAAY
GGGGRGMRVIRNEEELEKNFESAFREAETFFGKGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEI
APSPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKTGEYYFIEMNTRLQVEHTITEAITGVDIVEAMIRIAAGEP
LPYLQSDITFRGYAIEFRINAEDPKKNFAPAPGKITSYYSPGGPGVRIDASVYKDYIIPPYYDSMIAKMTVWALTWEKAV
ARARRALDEFVVRGVPTNIPLYREIVRDPDFLKGDFGTRFLEEKIAKGEYDFEIEGEKPMEDVVLAISAAIAAHYGL

Sequences:

>Translated_477_residues
MFRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLITGDPIRAYLDYVRIVDLAKQVGADAIHPG
YGFLAENADFARYCRRRGITFIGPTPEQIEMFGDKVKAKKVMKEVGLPTIPGTEEPVRTLEDAKHAVKEIGFPVMLKAAY
GGGGRGMRVIRNEEELEKNFESAFREAETFFGKGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEI
APSPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKTGEYYFIEMNTRLQVEHTITEAITGVDIVEAMIRIAAGEP
LPYLQSDITFRGYAIEFRINAEDPKKNFAPAPGKITSYYSPGGPGVRIDASVYKDYIIPPYYDSMIAKMTVWALTWEKAV
ARARRALDEFVVRGVPTNIPLYREIVRDPDFLKGDFGTRFLEEKIAKGEYDFEIEGEKPMEDVVLAISAAIAAHYGL
>Mature_477_residues
MFRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLITGDPIRAYLDYVRIVDLAKQVGADAIHPG
YGFLAENADFARYCRRRGITFIGPTPEQIEMFGDKVKAKKVMKEVGLPTIPGTEEPVRTLEDAKHAVKEIGFPVMLKAAY
GGGGRGMRVIRNEEELEKNFESAFREAETFFGKGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEI
APSPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKTGEYYFIEMNTRLQVEHTITEAITGVDIVEAMIRIAAGEP
LPYLQSDITFRGYAIEFRINAEDPKKNFAPAPGKITSYYSPGGPGVRIDASVYKDYIIPPYYDSMIAKMTVWALTWEKAV
ARARRALDEFVVRGVPTNIPLYREIVRDPDFLKGDFGTRFLEEKIAKGEYDFEIEGEKPMEDVVLAISAAIAAHYGL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=51.1160714285714, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=51.1160714285714, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=51.1160714285714, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=46.3636363636364, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=47.6404494382022, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=47.6404494382022, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=47.6404494382022, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI134142062, Length=526, Percent_Identity=30.0380228136882, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI38679977, Length=525, Percent_Identity=29.5238095238095, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679967, Length=525, Percent_Identity=29.5238095238095, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679960, Length=525, Percent_Identity=29.5238095238095, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI38679974, Length=525, Percent_Identity=29.5238095238095, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI38679971, Length=525, Percent_Identity=29.5238095238095, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI18105007, Length=360, Percent_Identity=24.7222222222222, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI169790915, Length=334, Percent_Identity=25.4491017964072, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI21361331, Length=334, Percent_Identity=25.4491017964072, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI170295797, Length=331, Percent_Identity=25.3776435045317, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=48.780487804878, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=28.75, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=51.3392857142857, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71987519, Length=475, Percent_Identity=45.8947368421053, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=476, Percent_Identity=44.327731092437, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931226, Length=515, Percent_Identity=29.9029126213592, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=534, Percent_Identity=28.6516853932584, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=534, Percent_Identity=28.6516853932584, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193204318, Length=348, Percent_Identity=22.1264367816092, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=49.2204899777283, Blast_Score=415, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=50.3340757238307, Blast_Score=408, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=43.2432432432432, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=31.7391304347826, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324343, Length=541, Percent_Identity=28.8354898336414, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322331, Length=349, Percent_Identity=23.4957020057307, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=51.1160714285714, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=44.4695259593679, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=43.980343980344, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI161076409, Length=527, Percent_Identity=30.1707779886148, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24586458, Length=527, Percent_Identity=30.1707779886148, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI161076407, Length=527, Percent_Identity=30.1707779886148, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24586460, Length=527, Percent_Identity=30.1707779886148, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24642586, Length=354, Percent_Identity=24.5762711864407, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45555749, Length=355, Percent_Identity=25.3521126760563, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.7 [H]

Molecular weight: Translated: 53671; Mature: 53671

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLITGDPIRAYL
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCEEEEECCHHHHHH
DYVRIVDLAKQVGADAIHPGYGFLAENADFARYCRRRGITFIGPTPEQIEMFGDKVKAKK
HHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
VMKEVGLPTIPGTEEPVRTLEDAKHAVKEIGFPVMLKAAYGGGGRGMRVIRNEEELEKNF
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHH
ESAFREAETFFGKGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEI
HHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHEE
APSPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKTGEYYFIEMNTRLQVEHTIT
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCEEEEHHHHH
EAITGVDIVEAMIRIAAGEPLPYLQSDITFRGYAIEFRINAEDPKKNFAPAPGKITSYYS
HHHHHHHHHHHHHHHHCCCCCCCHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEC
PGGPGVRIDASVYKDYIIPPYYDSMIAKMTVWALTWEKAVARARRALDEFVVRGVPTNIP
CCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LYREIVRDPDFLKGDFGTRFLEEKIAKGEYDFEIEGEKPMEDVVLAISAAIAAHYGL
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLITGDPIRAYL
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCEEEEECCHHHHHH
DYVRIVDLAKQVGADAIHPGYGFLAENADFARYCRRRGITFIGPTPEQIEMFGDKVKAKK
HHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
VMKEVGLPTIPGTEEPVRTLEDAKHAVKEIGFPVMLKAAYGGGGRGMRVIRNEEELEKNF
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHH
ESAFREAETFFGKGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEI
HHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHEE
APSPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKTGEYYFIEMNTRLQVEHTIT
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCEEEEHHHHH
EAITGVDIVEAMIRIAAGEPLPYLQSDITFRGYAIEFRINAEDPKKNFAPAPGKITSYYS
HHHHHHHHHHHHHHHHCCCCCCCHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEC
PGGPGVRIDASVYKDYIIPPYYDSMIAKMTVWALTWEKAVARARRALDEFVVRGVPTNIP
CCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LYREIVRDPDFLKGDFGTRFLEEKIAKGEYDFEIEGEKPMEDVVLAISAAIAAHYGL
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA