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The map label for this gene is nuoL3 [H]

Identifier: 15606573

GI number: 15606573

Start: 979710

End: 981644

Strand: Direct

Name: nuoL3 [H]

Synonym: aq_1379

Alternate gene names: 15606573

Gene position: 979710-981644 (Clockwise)

Preceding gene: 15606572

Following gene: 15606574

Centisome position: 63.15

GC content: 46.3

Gene sequence:

>1935_bases
ATGGAAGGACTGTTTGTAATATTTACGCCGCTAATAGCTTTTCTCATAATACTTGCATTCGGAAGAAAGATAGGGGATTT
AGGAAGCGGGATAATAGCGTCAGTAGGAGCAGGACTTACAACTCTTTTCTCTTTGGTAGTCGCCCTCAAAGCCATTCACT
CTCCTATTCACGTCAAACTCTACGACTTCCTCCCAATTGGCAATTACACACTCTCCCTCGGATTTTACTTTGACTCACTC
TCTTCCTTGATGGCACTTGTCGTCACATTCGTTGCCACTCTCATATTCGTCTACTCAATCGGCTACATGCGTGACGAGTT
CGGTAAATGGGTCTTCAAGTTCTACGCTTACCTATCACTCTTCCTCTTCGCTATGCTCCTTATCGTGCTTTCAGACAACC
TCCTCGGAATCTTCTTCGGCTGGGAAGGTGTGGGACTTGCTTCATACCTCCTTATCGGATACTACCACGAACAAAAAAAA
GCTACAAAAGCTTCCTTTGAAGCCTTCGTTATGAACAGAATAGGTGACTGGCTCTTTATCTTCGGTATCATCTACTCCTT
TTACCTCTTCAAAACCTTAGAAATCACTCAAATATTCCCGAAAGTCGAAGAAGTAGACAAGTACGCTCTTGGCGTTGCCA
CAATGCTCCTCTTTGGAGGAGCAGTCGGAAAGTCGGGACAATTTCCGCTCCACACGTGGCTTCCAAACGCAATGGCAGGT
CCGACTCCCGTGTCTGCACTCCTTCACGCAGCCACGATGGTAGCAGCTGGTGTCTACATGGTAGCAAGACTCTATCCCAT
GTTTGAAGCAACACCTCAAACGCTCAAGCTTATTGTTCTTATCGGAGCGATAACCATGACAATGGCAGCACTCGCAGGTG
CTGTTCACAACGACATAAAGAAGATAATCGCATTTTCAACGATGAGTCAGCTCGGATACATGTTTGTTGCTCTGGGAGTG
GGGGACAAGGGCGGAGCGATGTTCCACCTCACCACTCACGCTTTCTTCAAAGCCCTCCTGTTTTTAGCGGCTGGTGCTGT
AATAACAGCATTCCACCACCACCTTTACGACATCTTCAAGATGGGAGGGCTAAAGAAGTACATGCCTGTGACTTATGTGG
CGTTTATGATAGGGGCGCTCAGTTTGGCAGGAGTGTTTCCCTTCAGTGGTTTCTGGAGTAAAGACAGGATAGTGGCGAGC
ATGTACGAGTGGAGCGGAGTGCTTGGAGTTCTTGGAACGATAGTGGCGTTTATAACTGCATATTACGCGTTCAGGGAAGG
ATTTCTGGTGTTTCACGGAAGAGAGAGATGGAGGGAGATATACGATAAAGACGTTCATGAAGTAGAGGGAGTGATGACGG
TACCTATGGGGCTATTAGGATTTTTGACAGTTCTCACAGGGCTATTTGGCCTTTGGCTTGAGCACTGGTATGTAGGCTTG
ATAGGAGGGGAGGAGAAGGGGATACACCTGAGTGTTGCGCTAGTGTCGCTCGGAGTGGCAATAGCTGGGATATGGCTTGC
GTGGGCGGTATATGTGAAGGAGGTGATAGATTACAACAAAGCATATGAGTCTTTGAAGTTTATACACACGACTTTCAAGG
AGCAGTTCTTTACTGAAAAGCTCTACCACAACGTTATTGCGGGTGGGTACCTCGTAGTTTCTAGAGTAGCTTACAAGGTG
GGAGACAGAACCGTTATAGACGGCTTTATAAACGCCTTGTACAAGTACTTCTTTAAGTTCGTTAAGTTCCTGTGGAAGTA
CCTTGACATAAAGATTATTGACGTTCTTATACACGAGACTGTTCTAACCGCTTTCAGGCTCGGCAGGTTGTCAAGAAGGC
TTCAAACTGGGCTTGTGAACCACTACATACTGTTTTTGGCCGTAGGATTGACCTTTATCCTTGGAATCATGCTCTATATA
CTGGATAGACTCTAA

Upstream 100 bases:

>100_bases
CCGCTACTGAAGCCGCTGTGGGTCTCGGGATTATAATCGCCATATTCAGGTTGAAGAAGGTAGAAAGTACGGACGAAATA
AGAGAGCTGAGGGGCTGAGC

Downstream 100 bases:

>100_bases
GGGGTGGTGATATGGAAAAGGTGGGGTTTGAGTTTCCCATAATATCCGTTTCCCTGGCTATACCTGCGGTATTTGCCGTT
CTCATACTCTTCTTTAAAGA

Product: NADH dehydrogenase I chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKLYDFLPIGNYTLSLGFYFDSL
SSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKK
ATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAG
PTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVALGV
GDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVAS
MYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGL
IGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVIAGGYLVVSRVAYKV
GDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHETVLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYI
LDRL

Sequences:

>Translated_644_residues
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKLYDFLPIGNYTLSLGFYFDSL
SSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKK
ATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAG
PTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVALGV
GDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVAS
MYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGL
IGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVIAGGYLVVSRVAYKV
GDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHETVLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYI
LDRL
>Mature_644_residues
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKLYDFLPIGNYTLSLGFYFDSL
SSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSLFLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKK
ATKASFEAFVMNRIGDWLFIFGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAG
PTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIKKIIAFSTMSQLGYMFVALGV
GDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFKMGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVAS
MYEWSGVLGVLGTIVAFITAYYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGL
IGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEKLYHNVIAGGYLVVSRVAYKV
GDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHETVLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYI
LDRL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=392, Percent_Identity=38.5204081632653, Blast_Score=251, Evalue=1e-66,
Organism=Escherichia coli, GI1788614, Length=474, Percent_Identity=44.3037974683544, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788829, Length=353, Percent_Identity=33.7110481586402, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1788827, Length=443, Percent_Identity=29.5711060948081, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788831, Length=340, Percent_Identity=30, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI2367154, Length=335, Percent_Identity=25.9701492537313, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=382, Percent_Identity=23.2984293193717, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71949; Mature: 71949

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEE
YDFLPIGNYTLSLGFYFDSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSL
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKKATKASFEAFVMNRIGDWLFI
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC
PTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIIAFSTMSQLGYMFVALGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFK
HHHHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVASMYEWSGVLGVLGTIVAFITA
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGL
HHHHHCCCEEEECHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEK
ECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYHNVIAGGYLVVSRVAYKVGDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHET
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYILDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEGLFVIFTPLIAFLIILAFGRKIGDLGSGIIASVGAGLTTLFSLVVALKAIHSPIHVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEE
YDFLPIGNYTLSLGFYFDSLSSLMALVVTFVATLIFVYSIGYMRDEFGKWVFKFYAYLSL
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFAMLLIVLSDNLLGIFFGWEGVGLASYLLIGYYHEQKKATKASFEAFVMNRIGDWLFI
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIIYSFYLFKTLEITQIFPKVEEVDKYALGVATMLLFGGAVGKSGQFPLHTWLPNAMAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC
PTPVSALLHAATMVAAGVYMVARLYPMFEATPQTLKLIVLIGAITMTMAALAGAVHNDIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIIAFSTMSQLGYMFVALGVGDKGGAMFHLTTHAFFKALLFLAAGAVITAFHHHLYDIFK
HHHHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGGLKKYMPVTYVAFMIGALSLAGVFPFSGFWSKDRIVASMYEWSGVLGVLGTIVAFITA
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YYAFREGFLVFHGRERWREIYDKDVHEVEGVMTVPMGLLGFLTVLTGLFGLWLEHWYVGL
HHHHHCCCEEEECHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IGGEEKGIHLSVALVSLGVAIAGIWLAWAVYVKEVIDYNKAYESLKFIHTTFKEQFFTEK
ECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYHNVIAGGYLVVSRVAYKVGDRTVIDGFINALYKYFFKFVKFLWKYLDIKIIDVLIHET
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTAFRLGRLSRRLQTGLVNHYILFLAVGLTFILGIMLYILDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]