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The map label for this gene is gltP [H]

Identifier: 15606533

GI number: 15606533

Start: 943806

End: 945002

Strand: Direct

Name: gltP [H]

Synonym: aq_1330

Alternate gene names: 15606533

Gene position: 943806-945002 (Clockwise)

Preceding gene: 15606532

Following gene: 15606534

Centisome position: 60.84

GC content: 45.11

Gene sequence:

>1197_bases
GTGAAAAAACTCCTTTCCCTTGAGAACCTCACGCTCCTTTCCCTAATCCTTGCCGTCTTTTTTGGTATTTACTTTAAAGA
AATAGCCCTGAATATCAAACTCTTCGGGGACGTTTTCTTAAGTCTCCTGAAAATGATAATAGTCCCCCTCGTTTTTACCT
CCGTTTTCACCGCCATACTAAACCTTGAGAGTCTGGCAAAATTCAGGGATCTGGGTTTAAAAGCCTTTTTATACTACTTC
ACGACCACGGGAATGGCGGTTTTTACGGGACTTGTTCTCGTGAACATAATACAGCCGGGAAAGGGTGCAAGCGGAGTAAG
TGCAAAACCTGAAGAAATCCCGAAGGTTCAGGAGTTTTCTCTTGAGAACTTAATTCTCGGACTTATTCCCCAGAATCCCT
TTGAGGCTTTTTCTGAAGGAAAGGTTCTCCAGATTATAGTTTTCGCGGTCTTTATAGGACTTGCTGTTCTGACTATAGAT
AAGTTCAAACAGGAAATAATAAAGAACTTCTTTGAGGGTTTTAACGAAGCCCTAATACGACTGACAAAGTGGGTTATAGT
CTTAACTCCCGTGGGAGTTTTTGCCCTTGTTTCTTATCTGATAGCAAAGGTGGGGTATCAGGTTCTTATTTCCCTGTGGG
AATACGCACTAACCGTTTTGCTCGGCCTGCTCATACACGCCTTCGTAAATCTTCCATTAATTGCCTACATATTCGGAAGG
TACAATCCCTACAAGTACTTTATACAGGTGAGGGAAGCCCTGCTTCTTGCATTTTCCACTGCATCCAGCGCTGCAACGCT
TCCTGTCTCCCTTGAACTTGCAATCGAAAGGGGAAAGGTAAAAAAGGAAGTGGCTGGCTTTGTCCTGCCCTTGGGAGCTA
CCATAAACATGGACGGCACGGCCCTTTACGAGTCGGTGGCAGCTGTTTACATCGCAAACCTTTACGGAATAGACCTCTCA
ATCTCTCAAATGGTTACGATATTCCTGACCGCGACGCTTGCCTCTATCGGTGCTGCGGCAATTCCCGGAGCGGGTTTAGT
TCTCCTGACTTTAGTCCTCAGTTCCGTAGGGATTCCTTTAGAAGGTATAGGACTCATAATCGCAGTTGACAGGTTTCTGG
ACATGCTGAGAACTGCGGTAAACGTCTGGGGTGACCTGAACGGAGCTAAGATTCTGAATAGGTACGTAAACAGCTAA

Upstream 100 bases:

>100_bases
GGTAAAACTCAGGAAAGATCCAAAGTGTCCCCTTTGCGGAGAAAATCCAAAGATAAAGGAACTCATAGAGTACGACCAGA
GCTGTGAAGTGAGGTTTTAA

Downstream 100 bases:

>100_bases
AATTAAGAGGTATGCAAACATTACTGTACATTCTGTTTTTATTATTCCTTTTTTCCTGTTCAAAAACGGAGGAGAAAAAA
ACTCCCCAAGCGAGGAAAAT

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKKLLSLENLTLLSLILAVFFGIYFKEIALNIKLFGDVFLSLLKMIIVPLVFTSVFTAILNLESLAKFRDLGLKAFLYYF
TTTGMAVFTGLVLVNIIQPGKGASGVSAKPEEIPKVQEFSLENLILGLIPQNPFEAFSEGKVLQIIVFAVFIGLAVLTID
KFKQEIIKNFFEGFNEALIRLTKWVIVLTPVGVFALVSYLIAKVGYQVLISLWEYALTVLLGLLIHAFVNLPLIAYIFGR
YNPYKYFIQVREALLLAFSTASSAATLPVSLELAIERGKVKKEVAGFVLPLGATINMDGTALYESVAAVYIANLYGIDLS
ISQMVTIFLTATLASIGAAAIPGAGLVLLTLVLSSVGIPLEGIGLIIAVDRFLDMLRTAVNVWGDLNGAKILNRYVNS

Sequences:

>Translated_398_residues
MKKLLSLENLTLLSLILAVFFGIYFKEIALNIKLFGDVFLSLLKMIIVPLVFTSVFTAILNLESLAKFRDLGLKAFLYYF
TTTGMAVFTGLVLVNIIQPGKGASGVSAKPEEIPKVQEFSLENLILGLIPQNPFEAFSEGKVLQIIVFAVFIGLAVLTID
KFKQEIIKNFFEGFNEALIRLTKWVIVLTPVGVFALVSYLIAKVGYQVLISLWEYALTVLLGLLIHAFVNLPLIAYIFGR
YNPYKYFIQVREALLLAFSTASSAATLPVSLELAIERGKVKKEVAGFVLPLGATINMDGTALYESVAAVYIANLYGIDLS
ISQMVTIFLTATLASIGAAAIPGAGLVLLTLVLSSVGIPLEGIGLIIAVDRFLDMLRTAVNVWGDLNGAKILNRYVNS
>Mature_398_residues
MKKLLSLENLTLLSLILAVFFGIYFKEIALNIKLFGDVFLSLLKMIIVPLVFTSVFTAILNLESLAKFRDLGLKAFLYYF
TTTGMAVFTGLVLVNIIQPGKGASGVSAKPEEIPKVQEFSLENLILGLIPQNPFEAFSEGKVLQIIVFAVFIGLAVLTID
KFKQEIIKNFFEGFNEALIRLTKWVIVLTPVGVFALVSYLIAKVGYQVLISLWEYALTVLLGLLIHAFVNLPLIAYIFGR
YNPYKYFIQVREALLLAFSTASSAATLPVSLELAIERGKVKKEVAGFVLPLGATINMDGTALYESVAAVYIANLYGIDLS
ISQMVTIFLTATLASIGAAAIPGAGLVLLTLVLSSVGIPLEGIGLIIAVDRFLDMLRTAVNVWGDLNGAKILNRYVNS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=411, Percent_Identity=38.1995133819951, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI169790839, Length=446, Percent_Identity=35.2017937219731, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI40254478, Length=449, Percent_Identity=35.4120267260579, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI194239697, Length=456, Percent_Identity=32.6754385964912, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=33.25, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4827012, Length=256, Percent_Identity=43.75, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI223468564, Length=259, Percent_Identity=40.5405405405405, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=39.7849462365591, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI5032093, Length=259, Percent_Identity=40.5405405405405, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI262359914, Length=401, Percent_Identity=30.6733167082294, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI301601644, Length=150, Percent_Identity=40.6666666666667, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790514, Length=362, Percent_Identity=36.1878453038674, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1789947, Length=381, Percent_Identity=30.9711286089239, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788024, Length=386, Percent_Identity=30.3108808290155, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789473, Length=373, Percent_Identity=29.4906166219839, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=38.4955752212389, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983099, Length=440, Percent_Identity=34.7727272727273, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71983106, Length=440, Percent_Identity=34.7727272727273, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17537407, Length=392, Percent_Identity=37.5, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17541374, Length=413, Percent_Identity=33.8983050847458, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=433, Percent_Identity=30.4849884526559, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193206654, Length=404, Percent_Identity=28.2178217821782, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24583025, Length=419, Percent_Identity=34.8448687350835, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17137668, Length=419, Percent_Identity=34.8448687350835, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24583023, Length=419, Percent_Identity=34.8448687350835, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI281360483, Length=467, Percent_Identity=30.1927194860814, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17137666, Length=467, Percent_Identity=30.1927194860814, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281360481, Length=289, Percent_Identity=35.2941176470588, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43391; Mature: 43391

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLSLENLTLLSLILAVFFGIYFKEIALNIKLFGDVFLSLLKMIIVPLVFTSVFTAIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLESLAKFRDLGLKAFLYYFTTTGMAVFTGLVLVNIIQPGKGASGVSAKPEEIPKVQEFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHH
LENLILGLIPQNPFEAFSEGKVLQIIVFAVFIGLAVLTIDKFKQEIIKNFFEGFNEALIR
HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKWVIVLTPVGVFALVSYLIAKVGYQVLISLWEYALTVLLGLLIHAFVNLPLIAYIFGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YNPYKYFIQVREALLLAFSTASSAATLPVSLELAIERGKVKKEVAGFVLPLGATINMDGT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHEECCCEECCCHH
ALYESVAAVYIANLYGIDLSISQMVTIFLTATLASIGAAAIPGAGLVLLTLVLSSVGIPL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHHCCCCC
EGIGLIIAVDRFLDMLRTAVNVWGDLNGAKILNRYVNS
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]