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The map label for this gene is pbpA1 [H]

Identifier: 15606433

GI number: 15606433

Start: 837078

End: 838865

Strand: Direct

Name: pbpA1 [H]

Synonym: aq_1189

Alternate gene names: 15606433

Gene position: 837078-838865 (Clockwise)

Preceding gene: 15606432

Following gene: 15606435

Centisome position: 53.96

GC content: 43.9

Gene sequence:

>1788_bases
ATGAAAAGGCGTAGTTTTATCCTGATGCTTTTGTCCGCGATAGGGAGTTTTATCGGAGTTGTTGGGAATCTTTTCAGGAT
CCAAGTTCTTGAGGGAAAGAAGTACAGGGAGCTTTCCGAGAGGAATTACGAGAGGGAAAGGTACCTTTACCCGCCGAGGG
GGGATATATACGACAGGAACGGGGTCAAACTCGCTTACGACGTTCCTAAATACGTCCTCGTTCTTGACGCTTACAGACTC
GGAAAAGAAGAACTCAAAAAGACCTTGGAAAACTTAAAGGAATTATTCGGAATTGAGATTGATAAAAGGAAAGTTCTCAA
GGGGGGATTTGAACCGCAAGTGGTAAAGGAGGAGTTAACTCCCAAGGAGCTGGAAATATATTACGAAAACAAGGAAATAC
TTCCGGGAGTCTTTATAGAAGTTATACCCAAAAGGGTTTACCCGTACGGGGAGCTTGCGTCTCATATTTTGGGATACGTG
GGGTATCCCAACGAAAGGGACTTTAAAAGGATAAAGAAAGAAATAGGGAGTAAAAGTTTTGTCGGGAAGATGGGAATAGA
ACGGGTGTTTGACGAAAAGCTACTCGGGGAACTCGGAAAGGAAAGGGTTATGGTAAACGCAATTGGGGGAATAGTAAAAG
TTCTCGAAAGGAGAGAACCGAAGAAAGGAAACTCCGTAAAGCTCACGATCGATTACAGATTTCAAAAAATAGTGGAGGAG
GTTTTTAAGGAAAGCGGACACCCAGCGGGAGCCGTAATCCTTTTGAAAGCTTCCACAGGAGAAGTTCTCGCCCTTGCGAG
TTTTCCCAACTTCAACCCGAACAAGGTTTACGAAGAGTGGAAAAGTCTCGTAAAAAATCCCTTGAAACCTCTCTTTAACA
GGGCTATTAGGGGACTGTATCCGCCCGCTTCTGTCTTTAAAGTCCCTATGGCTTTTGCTACACTGAGTGCAAAGATAAGG
AGTCCTTGGGAAAAGGTTTTTTGTCCCGGATACTACGAACTAGGGGACAGGAAATTTTACTGCTGGAGGAGGTGGGGACA
CGGTAAGGTGGATCTTATTAAAAGTCTTTCGGAATCATGCGACGTTTACTACTACACCGCAGGTTACAAACTTGGCCCTA
CTAAGATACGCTACTACGCCAAAAGGTTTTCTTACGGTGAACGTATTCCCTTTGAACTTCCCGTAAGGAAAGGTTTCATA
CCGACACCGAGGTGGAAACTCAGGCGCTTTAAAGAACCGTGGTACGATGGGGATACCGTTAACATGAGTATAGGGCAGGG
ATTTGTGCTGAGTAACTTAATGGAACAGACCTTAATGATGATGGGTATAGCGAATAACGGAGTTATATACAAACCGACGC
TTTTGAAGGAAATACTCGACGATAAAGGAAACGTGATATTCAGAAATAAAAGGGAAGTCTGGAAAGCGGTTTACGGCAGT
CTTGAGCATTTTGCTTTGATAAAGAGAGGATTGAGAGACGCGGTGAGAAAGGGAACCGCAAAACTCGCATTCTCCAGAAT
AGTGGACATAGCGGGAAAAACGGGAACCGCGGAAGTTTTCTTCAAAAATAAGAGAAAGATTAAAAAGAAGTACAAGAAAA
TGAGAAAGAAACTTCCCTGGAAGTACAGAAACCACGCGTGGTTTGTGGGATTTGCACCCTACAGGGACCCTAAATTCGTC
ATCGGAGTTTTTGTTGAGCACGGAGAGAGCGGAGGAAAAACAGCAGCCCCCATAGCAAGAAAGATTCTGGAGAGGATATA
CATAGAAAAACTCCATAAAGAACTTTAA

Upstream 100 bases:

>100_bases
AAGTTTCCCTTAAATATCGGCTTAAAAGATTTCGGTGTTGTTCTATTAATAGATCTCATATTTCTGATACTCCTCTACAA
GGTGTTTAATAAATACGTAT

Downstream 100 bases:

>100_bases
AGTTTTTTGTAGTAAGCCCCTTCCTGTACAACTTTTCCTTGAATTATTAAAGAACTAAGAATTTTGAAAACTTCTTTCCT
TTCCCTTTTCAGGAAGCTAA

Product: penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MKRRSFILMLLSAIGSFIGVVGNLFRIQVLEGKKYRELSERNYERERYLYPPRGDIYDRNGVKLAYDVPKYVLVLDAYRL
GKEELKKTLENLKELFGIEIDKRKVLKGGFEPQVVKEELTPKELEIYYENKEILPGVFIEVIPKRVYPYGELASHILGYV
GYPNERDFKRIKKEIGSKSFVGKMGIERVFDEKLLGELGKERVMVNAIGGIVKVLERREPKKGNSVKLTIDYRFQKIVEE
VFKESGHPAGAVILLKASTGEVLALASFPNFNPNKVYEEWKSLVKNPLKPLFNRAIRGLYPPASVFKVPMAFATLSAKIR
SPWEKVFCPGYYELGDRKFYCWRRWGHGKVDLIKSLSESCDVYYYTAGYKLGPTKIRYYAKRFSYGERIPFELPVRKGFI
PTPRWKLRRFKEPWYDGDTVNMSIGQGFVLSNLMEQTLMMMGIANNGVIYKPTLLKEILDDKGNVIFRNKREVWKAVYGS
LEHFALIKRGLRDAVRKGTAKLAFSRIVDIAGKTGTAEVFFKNKRKIKKKYKKMRKKLPWKYRNHAWFVGFAPYRDPKFV
IGVFVEHGESGGKTAAPIARKILERIYIEKLHKEL

Sequences:

>Translated_595_residues
MKRRSFILMLLSAIGSFIGVVGNLFRIQVLEGKKYRELSERNYERERYLYPPRGDIYDRNGVKLAYDVPKYVLVLDAYRL
GKEELKKTLENLKELFGIEIDKRKVLKGGFEPQVVKEELTPKELEIYYENKEILPGVFIEVIPKRVYPYGELASHILGYV
GYPNERDFKRIKKEIGSKSFVGKMGIERVFDEKLLGELGKERVMVNAIGGIVKVLERREPKKGNSVKLTIDYRFQKIVEE
VFKESGHPAGAVILLKASTGEVLALASFPNFNPNKVYEEWKSLVKNPLKPLFNRAIRGLYPPASVFKVPMAFATLSAKIR
SPWEKVFCPGYYELGDRKFYCWRRWGHGKVDLIKSLSESCDVYYYTAGYKLGPTKIRYYAKRFSYGERIPFELPVRKGFI
PTPRWKLRRFKEPWYDGDTVNMSIGQGFVLSNLMEQTLMMMGIANNGVIYKPTLLKEILDDKGNVIFRNKREVWKAVYGS
LEHFALIKRGLRDAVRKGTAKLAFSRIVDIAGKTGTAEVFFKNKRKIKKKYKKMRKKLPWKYRNHAWFVGFAPYRDPKFV
IGVFVEHGESGGKTAAPIARKILERIYIEKLHKEL
>Mature_595_residues
MKRRSFILMLLSAIGSFIGVVGNLFRIQVLEGKKYRELSERNYERERYLYPPRGDIYDRNGVKLAYDVPKYVLVLDAYRL
GKEELKKTLENLKELFGIEIDKRKVLKGGFEPQVVKEELTPKELEIYYENKEILPGVFIEVIPKRVYPYGELASHILGYV
GYPNERDFKRIKKEIGSKSFVGKMGIERVFDEKLLGELGKERVMVNAIGGIVKVLERREPKKGNSVKLTIDYRFQKIVEE
VFKESGHPAGAVILLKASTGEVLALASFPNFNPNKVYEEWKSLVKNPLKPLFNRAIRGLYPPASVFKVPMAFATLSAKIR
SPWEKVFCPGYYELGDRKFYCWRRWGHGKVDLIKSLSESCDVYYYTAGYKLGPTKIRYYAKRFSYGERIPFELPVRKGFI
PTPRWKLRRFKEPWYDGDTVNMSIGQGFVLSNLMEQTLMMMGIANNGVIYKPTLLKEILDDKGNVIFRNKREVWKAVYGS
LEHFALIKRGLRDAVRKGTAKLAFSRIVDIAGKTGTAEVFFKNKRKIKKKYKKMRKKLPWKYRNHAWFVGFAPYRDPKFV
IGVFVEHGESGGKTAAPIARKILERIYIEKLHKEL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=619, Percent_Identity=29.7253634894992, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1786272, Length=596, Percent_Identity=22.4832214765101, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68985; Mature: 68985

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRSFILMLLSAIGSFIGVVGNLFRIQVLEGKKYRELSERNYERERYLYPPRGDIYDRN
CCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHHHCCCCHHCEECCCCCCCCCCC
GVKLAYDVPKYVLVLDAYRLGKEELKKTLENLKELFGIEIDKRKVLKGGFEPQVVKEELT
CCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
PKELEIYYENKEILPGVFIEVIPKRVYPYGELASHILGYVGYPNERDFKRIKKEIGSKSF
CCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
VGKMGIERVFDEKLLGELGKERVMVNAIGGIVKVLERREPKKGNSVKLTIDYRFQKIVEE
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHH
VFKESGHPAGAVILLKASTGEVLALASFPNFNPNKVYEEWKSLVKNPLKPLFNRAIRGLY
HHHHCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPASVFKVPMAFATLSAKIRSPWEKVFCPGYYELGDRKFYCWRRWGHGKVDLIKSLSESC
CCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHCC
DVYYYTAGYKLGPTKIRYYAKRFSYGERIPFELPVRKGFIPTPRWKLRRFKEPWYDGDTV
CEEEEECCCEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEE
NMSIGQGFVLSNLMEQTLMMMGIANNGVIYKPTLLKEILDDKGNVIFRNKREVWKAVYGS
EEECCCCHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHCCCCCEEEECHHHHHHHHHHH
LEHFALIKRGLRDAVRKGTAKLAFSRIVDIAGKTGTAEVFFKNKRKIKKKYKKMRKKLPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHCCCC
KYRNHAWFVGFAPYRDPKFVIGVFVEHGESGGKTAAPIARKILERIYIEKLHKEL
EECCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRRSFILMLLSAIGSFIGVVGNLFRIQVLEGKKYRELSERNYERERYLYPPRGDIYDRN
CCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHHHCCCCHHCEECCCCCCCCCCC
GVKLAYDVPKYVLVLDAYRLGKEELKKTLENLKELFGIEIDKRKVLKGGFEPQVVKEELT
CCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
PKELEIYYENKEILPGVFIEVIPKRVYPYGELASHILGYVGYPNERDFKRIKKEIGSKSF
CCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
VGKMGIERVFDEKLLGELGKERVMVNAIGGIVKVLERREPKKGNSVKLTIDYRFQKIVEE
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHH
VFKESGHPAGAVILLKASTGEVLALASFPNFNPNKVYEEWKSLVKNPLKPLFNRAIRGLY
HHHHCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPASVFKVPMAFATLSAKIRSPWEKVFCPGYYELGDRKFYCWRRWGHGKVDLIKSLSESC
CCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHCC
DVYYYTAGYKLGPTKIRYYAKRFSYGERIPFELPVRKGFIPTPRWKLRRFKEPWYDGDTV
CEEEEECCCEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEE
NMSIGQGFVLSNLMEQTLMMMGIANNGVIYKPTLLKEILDDKGNVIFRNKREVWKAVYGS
EEECCCCHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHCCCCCEEEECHHHHHHHHHHH
LEHFALIKRGLRDAVRKGTAKLAFSRIVDIAGKTGTAEVFFKNKRKIKKKYKKMRKKLPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHCCCC
KYRNHAWFVGFAPYRDPKFVIGVFVEHGESGGKTAAPIARKILERIYIEKLHKEL
EECCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]