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The map label for this gene is sahH

Identifier: 15606424

GI number: 15606424

Start: 829334

End: 830590

Strand: Direct

Name: sahH

Synonym: aq_1180

Alternate gene names: 15606424

Gene position: 829334-830590 (Clockwise)

Preceding gene: 15606423

Following gene: 15606432

Centisome position: 53.46

GC content: 46.62

Gene sequence:

>1257_bases
ATGGAATTTGACGTGAAGGATTTGTCCTTAGCGGAAGAGGGATTGAAGAGGATTGAGTGGGCTGAAATGGACATGCCCGT
CCTCAGGCAGATAAGGGAAAGATTTTCAAAGGAAAAACCCCTGAAAGGTAAGAAGATTTCCGCATGCCTTCACGTAACTA
CGGAGACCGCTAACCTTATGAGAACTTTGAAGGAAGGAGGAGCGGAAGTTTACCTAACGGCTTCAAATCCACTATCCACG
CAGGACGACGTTGCGGCGGCACTCGTAAAGTACTTTGAAATTCCCGTTTTTGCAATCAGAGGAGAGGACAGGGAAACTTA
TTACAAGCATCTGAGGGCTGTGATAGAAAAGGAACCGGACGTTGTTATTGACGACGGTGCGGATTTAATTTCAACGCTTC
ACAAAGAATACCCCGGGCTTGCGGAAAAGGTTCTCGGCGGTATGGAGGAAACCACAACGGGAGTTATAAGACTGAGGGCT
ATGGCAGAACAAGGAGTTTTAAAGTTTCCCATAATAGCGGTAAACGACGCATACACAAAACACATGTTTGACAACAGGTA
CGGAACGGGTCAGTCTACGATAGACGGTATTTTGAGGGCTACTAACAGACTTCTGGCGGGTTCATACTTCGTAGTTGCGG
GTTACGGGTGGTGTGGAAAAGGAGTTGCTCAAAGGGCAAGGGGAATGGGAGCGATAGTGATAGTTACGGAAGTTGATCCG
ATAAAGGCTCTGGAAGCCAGAATGGACGGATTTCTGGTAATGCCTATGGAAGAGGCGGCAAAGCTCGGTGACTTTTTCGT
GACCGTCACGGGAAACATACACGTCATTAGAAGAGAACACTTTGAAGTAATGAAGGATGGTGCCATAGTTGCAAACAGCG
GACACTTTAACGTGGAAATAGACATTCCGGCACTTGAAGAAATGGCGGTAGAAAAAAGGGAAATAAGGAAAGAAGTTACG
GAGTACAAATTAAAGGACGGAAGGAGGATATACCTCCTTGCGGAAGGGAGGCTCGTGAACTTAGCTGCCGCGGAAGGTCA
CCCAGCATCTGTTATGGACATGTCCTTCTCAAACCAGGCTCTGAGTGCTGAATACATAGTAAAACACCACAAAGAACTCG
AAAAAAAGGTTTACAGAGTTCCGAGGGAAATAGACGAGGCTGTTGCAAGGTTAAAGTTAAACGCCTTGGGAATAAAGATA
GACGAACTCACGGAAGAGCAGAAGAAATACCTGAGTTCCTGGGAAATGGGCACCTGA

Upstream 100 bases:

>100_bases
ATAAAGTACCCCGAGTATGCTAAGAAATTGGACGAGTACACGGAAAAACTGAAGGAGAAAGTGGCTAAAATGAACGAAGA
ACTGCAAAAGGAGGTGGAAA

Downstream 100 bases:

>100_bases
GGGCTCAGCCCTCTTTTAACCACTTTTTCAGTACCATAGCCACTTTTTCGGGTTCCTGCTTTGCGATTTCCAGCAATTCT
TCGTAAGGTGTCTTCTTTCT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLTASNPLST
QDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDVVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRA
MAEQGVLKFPIIAVNDAYTKHMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDP
IKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPALEEMAVEKREIRKEVT
EYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQALSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKI
DELTEEQKKYLSSWEMGT

Sequences:

>Translated_418_residues
MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLTASNPLST
QDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDVVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRA
MAEQGVLKFPIIAVNDAYTKHMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDP
IKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPALEEMAVEKREIRKEVT
EYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQALSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKI
DELTEEQKKYLSSWEMGT
>Mature_418_residues
MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLTASNPLST
QDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDVVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRA
MAEQGVLKFPIIAVNDAYTKHMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDP
IKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPALEEMAVEKREIRKEVT
EYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQALSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKI
DELTEEQKKYLSSWEMGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=414, Percent_Identity=49.2753623188406, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=50.2564102564103, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI298286489, Length=414, Percent_Identity=41.0628019323672, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI195539349, Length=414, Percent_Identity=41.0628019323672, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI195539337, Length=414, Percent_Identity=41.0628019323672, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI24308043, Length=414, Percent_Identity=41.0628019323672, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI21361647, Length=414, Percent_Identity=39.8550724637681, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=45.1923076923077, Blast_Score=335, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6320882, Length=435, Percent_Identity=44.5977011494253, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24642172, Length=419, Percent_Identity=45.1073985680191, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=40.547263681592, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI45553385, Length=413, Percent_Identity=40.4358353510896, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45553387, Length=413, Percent_Identity=40.4358353510896, Blast_Score=281, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_AQUAE (O67240)

Other databases:

- EMBL:   AE000657
- PIR:   E70401
- RefSeq:   NP_213804.1
- ProteinModelPortal:   O67240
- SMR:   O67240
- GeneID:   1192586
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1180
- NMPDR:   fig|224324.1.peg.819
- HOGENOM:   HBG352029
- OMA:   FLFEQKY
- PhylomeDB:   O67240
- ProtClustDB:   PRK05476
- BioCyc:   AAEO224324:AQ_1180-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 46841; Mature: 46841

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 53-53 BINDING 125-125 BINDING 150-150 BINDING 180-180 BINDING 184-184 BINDING 185-185 BINDING 237-237 BINDING 272-272 BINDING 340-340

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLM
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHH
RTLKEGGAEVYLTASNPLSTQDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPD
HHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCC
VVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRAMAEQGVLKFPIIAVNDAYTK
EEEECCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHH
HMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEEEECCCH
IKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEI
HHHHHHHCCCEEEEEHHHHHCCCCEEEEEECCEEEEEHHHHHHHHCCEEEECCCEEEEEE
DIPALEEMAVEKREIRKEVTEYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQA
ECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCH
LSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKIDELTEEQKKYLSSWEMGT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLM
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHH
RTLKEGGAEVYLTASNPLSTQDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPD
HHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCC
VVIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRAMAEQGVLKFPIIAVNDAYTK
EEEECCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHH
HMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEEEECCCH
IKALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEI
HHHHHHHCCCEEEEEHHHHHCCCCEEEEEECCEEEEEHHHHHHHHCCEEEECCCEEEEEE
DIPALEEMAVEKREIRKEVTEYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQA
ECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCH
LSAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKIDELTEEQKKYLSSWEMGT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320