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The map label for this gene is purE

Identifier: 15606423

GI number: 15606423

Start: 828841

End: 829344

Strand: Direct

Name: purE

Synonym: aq_1178

Alternate gene names: 15606423

Gene position: 828841-829344 (Clockwise)

Preceding gene: 15606421

Following gene: 15606424

Centisome position: 53.43

GC content: 47.82

Gene sequence:

>504_bases
ATGAAACCACTCGTTGGCGTAATAATGGGAAGTATTTCCGACTGGGAGTATATGAAAAAGGCTGTTGAAGTTTTAAAGGA
ATTCGGAGTTCCTCACGAGGTTAAAGTGGTCTCCGCACACAGAACGCCCGAACTCATGTATGAATACGCAAAAACCGCAA
GGGAGAGGGGAATAGAGGTGATAATAGCGGGAGCGGGAGGCTCCGCCCATCTTCCGGGAATGACCGCCTCTATGACTACA
CTTCCCGTTATAGGCGTTCCCATACCCACTAAAAACCTCGGAGGAGTGGACTCGTTGTACTCGATAGTCCAGATGCCAGC
GGGTATTCCCGTGGCTACGGTGGCTATAGGAAACGCAACAAATGCCGGGCTCTTAGCGGTAAGAATTCTCTCAATAAAGT
ACCCCGAGTATGCTAAGAAATTGGACGAGTACACGGAAAAACTGAAGGAGAAAGTGGCTAAAATGAACGAAGAACTGCAA
AAGGAGGTGGAAAATGGAATTTGA

Upstream 100 bases:

>100_bases
TTTTTAAGACATAATTTGTAAAAGCTAGAGCGGGAAAAAAGTGTCCGCCCGTTCCTCCTCCTGATACAGCGATCATCTTG
ATATTTTAAACTTTTCTTTT

Downstream 100 bases:

>100_bases
CGTGAAGGATTTGTCCTTAGCGGAAGAGGGATTGAAGAGGATTGAGTGGGCTGAAATGGACATGCCCGTCCTCAGGCAGA
TAAGGGAAAGATTTTCAAAG

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MKPLVGVIMGSISDWEYMKKAVEVLKEFGVPHEVKVVSAHRTPELMYEYAKTARERGIEVIIAGAGGSAHLPGMTASMTT
LPVIGVPIPTKNLGGVDSLYSIVQMPAGIPVATVAIGNATNAGLLAVRILSIKYPEYAKKLDEYTEKLKEKVAKMNEELQ
KEVENGI

Sequences:

>Translated_167_residues
MKPLVGVIMGSISDWEYMKKAVEVLKEFGVPHEVKVVSAHRTPELMYEYAKTARERGIEVIIAGAGGSAHLPGMTASMTT
LPVIGVPIPTKNLGGVDSLYSIVQMPAGIPVATVAIGNATNAGLLAVRILSIKYPEYAKKLDEYTEKLKEKVAKMNEELQ
KEVENGI
>Mature_167_residues
MKPLVGVIMGSISDWEYMKKAVEVLKEFGVPHEVKVVSAHRTPELMYEYAKTARERGIEVIIAGAGGSAHLPGMTASMTT
LPVIGVPIPTKNLGGVDSLYSIVQMPAGIPVATVAIGNATNAGLLAVRILSIKYPEYAKKLDEYTEKLKEKVAKMNEELQ
KEVENGI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=59.0909090909091, Blast_Score=141, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324702, Length=160, Percent_Identity=59.375, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_AQUAE (O67239)

Other databases:

- EMBL:   AE000657
- PIR:   D70401
- RefSeq:   NP_213803.1
- ProteinModelPortal:   O67239
- SMR:   O67239
- GeneID:   1192585
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1178
- NMPDR:   fig|224324.1.peg.818
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- PhylomeDB:   O67239
- ProtClustDB:   CLSK2748425
- BioCyc:   AAEO224324:AQ_1178-MONOMER
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 18037; Mature: 18037

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: BINDING 11-11 BINDING 14-14 BINDING 41-41

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLVGVIMGSISDWEYMKKAVEVLKEFGVPHEVKVVSAHRTPELMYEYAKTARERGIEV
CCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGSAHLPGMTASMTTLPVIGVPIPTKNLGGVDSLYSIVQMPAGIPVATVAIGNAT
EEECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVRILSIKYPEYAKKLDEYTEKLKEKVAKMNEELQKEVENGI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPLVGVIMGSISDWEYMKKAVEVLKEFGVPHEVKVVSAHRTPELMYEYAKTARERGIEV
CCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEE
IIAGAGGSAHLPGMTASMTTLPVIGVPIPTKNLGGVDSLYSIVQMPAGIPVATVAIGNAT
EEECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVRILSIKYPEYAKKLDEYTEKLKEKVAKMNEELQKEVENGI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320