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The map label for this gene is purQ

Identifier: 15606374

GI number: 15606374

Start: 772057

End: 772740

Strand: Direct

Name: purQ

Synonym: aq_1105

Alternate gene names: 15606374

Gene position: 772057-772740 (Clockwise)

Preceding gene: 15606373

Following gene: 15606375

Centisome position: 49.77

GC content: 49.12

Gene sequence:

>684_bases
ATGAAGTTTGCGGTTTGCGTTTTTCCCGGTTCTAACTGCGATTACGACACCTACTACGTTATAAGGGACATTCTTGAAAA
GGACGTGGAATTCGTTTACTGGGAAGAAAAGAACCTTTCCAAGTACGACGTCGTTGTTCTGCCAGGAGGATTTTCCTTCG
GGGATTACCTCAGACCCGGAGCTCTGGCGGCAAGAACTCCCCTCGCTCAGGCCATTTACGATTTTGCCCAGAAGGGGAAG
TACGTGATAGGCATATGCAACGGCTTTCAAATCCTCACAGAACTCGGGCTGCTTCCGGGAGCTCTCCTTCCCAACTTGAA
CATGAGGTTCGTGTGCAAGTGGGTAAACCTTAGGGTTGAAAATGAGCGCTCCGCCTTTACGAGGAAACTGGAAAAGGGAG
ACGTTTTAAGAATTCCCATAGCCCACCACGACGGGAGGTATTACGTTCCCGAAGAAGAGCTCAGGAAAATGGAAGAAAAT
GGACAGATACTCTTCAGGTACTGCGACGAGCAGGGAGAAGTGAAGGAGGAAGTAAACCCTAACGGTTCGGTTTCAAATAT
AGCGGGAGTTATGAACAAGGAGGGGAACGTCTTTGGCATGATGCCCCACCCTGAAAGGGCGTCAGAAGACATTCTGGGCT
CTCACGACGGGCTGATGCTGTGGTATTCTTTATTAAGTGATTAG

Upstream 100 bases:

>100_bases
TTTACTTTCAGGACACAGTGCAGTTGCTGAGGGATTTCTTGACCTCAAGACTGGAGAGGGAAGTTGTGAAAAATACTTCT
CATGGTGGATAATCTTTTTT

Downstream 100 bases:

>100_bases
TCCTGAGCTCGTAAAGGAAGCCTTAAAAAAGAAAAAAGTAAGGAGCGAAGAAGCCTTCGGCCTTGAGTATCTGAGGTTTA
ACGACGACTACAAGGACATA

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKFAVCVFPGSNCDYDTYYVIRDILEKDVEFVYWEEKNLSKYDVVVLPGGFSFGDYLRPGALAARTPLAQAIYDFAQKGK
YVIGICNGFQILTELGLLPGALLPNLNMRFVCKWVNLRVENERSAFTRKLEKGDVLRIPIAHHDGRYYVPEEELRKMEEN
GQILFRYCDEQGEVKEEVNPNGSVSNIAGVMNKEGNVFGMMPHPERASEDILGSHDGLMLWYSLLSD

Sequences:

>Translated_227_residues
MKFAVCVFPGSNCDYDTYYVIRDILEKDVEFVYWEEKNLSKYDVVVLPGGFSFGDYLRPGALAARTPLAQAIYDFAQKGK
YVIGICNGFQILTELGLLPGALLPNLNMRFVCKWVNLRVENERSAFTRKLEKGDVLRIPIAHHDGRYYVPEEELRKMEEN
GQILFRYCDEQGEVKEEVNPNGSVSNIAGVMNKEGNVFGMMPHPERASEDILGSHDGLMLWYSLLSD
>Mature_227_residues
MKFAVCVFPGSNCDYDTYYVIRDILEKDVEFVYWEEKNLSKYDVVVLPGGFSFGDYLRPGALAARTPLAQAIYDFAQKGK
YVIGICNGFQILTELGLLPGALLPNLNMRFVCKWVNLRVENERSAFTRKLEKGDVLRIPIAHHDGRYYVPEEELRKMEEN
GQILFRYCDEQGEVKEEVNPNGSVSNIAGVMNKEGNVFGMMPHPERASEDILGSHDGLMLWYSLLSD

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=198, Percent_Identity=32.3232323232323, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI48994899, Length=183, Percent_Identity=32.2404371584699, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17553022, Length=194, Percent_Identity=26.2886597938144, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321498, Length=181, Percent_Identity=33.1491712707182, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24582111, Length=191, Percent_Identity=30.8900523560209, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582109, Length=191, Percent_Identity=30.8900523560209, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137292, Length=191, Percent_Identity=30.8900523560209, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_AQUAE (O67190)

Other databases:

- EMBL:   AE000657
- PIR:   C70395
- RefSeq:   NP_213753.1
- ProteinModelPortal:   O67190
- GeneID:   1193824
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1105
- NMPDR:   fig|224324.1.peg.768
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   AAEO224324:AQ_1105-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 25820; Mature: 25820

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 203-203 ACT_SITE 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVCVFPGSNCDYDTYYVIRDILEKDVEFVYWEEKNLSKYDVVVLPGGFSFGDYLRPG
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHCCCC
ALAARTPLAQAIYDFAQKGKYVIGICNGFQILTELGLLPGALLPNLNMRFVCKWVNLRVE
CHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHCCCCCCEEEEEEEEEEEC
NERSAFTRKLEKGDVLRIPIAHHDGRYYVPEEELRKMEENGQILFRYCDEQGEVKEEVNP
CCHHHHHHHHCCCCEEEEEEEECCCEEECCHHHHHHHHCCCCEEEEEECCCCCHHHHCCC
NGSVSNIAGVMNKEGNVFGMMPHPERASEDILGSHDGLMLWYSLLSD
CCCHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKFAVCVFPGSNCDYDTYYVIRDILEKDVEFVYWEEKNLSKYDVVVLPGGFSFGDYLRPG
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHCCCC
ALAARTPLAQAIYDFAQKGKYVIGICNGFQILTELGLLPGALLPNLNMRFVCKWVNLRVE
CHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHCCCCCCEEEEEEEEEEEC
NERSAFTRKLEKGDVLRIPIAHHDGRYYVPEEELRKMEENGQILFRYCDEQGEVKEEVNP
CCHHHHHHHHCCCCEEEEEEEECCCEEECCHHHHHHHHCCCCEEEEEECCCCCHHHHCCC
NGSVSNIAGVMNKEGNVFGMMPHPERASEDILGSHDGLMLWYSLLSD
CCCHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320