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The map label for this gene is czcD [H]

Identifier: 15606352

GI number: 15606352

Start: 744788

End: 745714

Strand: Direct

Name: czcD [H]

Synonym: aq_1073

Alternate gene names: 15606352

Gene position: 744788-745714 (Clockwise)

Preceding gene: 15606351

Following gene: 15606353

Centisome position: 48.01

GC content: 46.49

Gene sequence:

>927_bases
ATGGAAAGGGAAAAAAGCTTAAAAGTTCTTGCTTTTAGTTTCCTATTAATATTTCTCTTTGCTTTTATTGAATTCCTCGG
CGGACTGCTCACAAACAGTTTGGCTCTCCTCTCAGATGCCGGCCACATGCTCACGGACGCTGTATCCCTTTCTATAGCAC
TCGTTGCCCAGTACTTAGCTCTCAAAGTAAAGACGAAGAGGACGACTTACGGACTCTACAGACTCGAAGTTCTCGCCGCA
CTCGTAAACGGAGTCTTCCTCTTAGGACTTATAGGCTACATAATCCTCGAAGCTATTCACAGATTTGAAAACCCTGAACC
AGTGAAACCTCAGATGATATACATAGCCTTTGCGGGACTGATTGTTAACCTCGTAGTGGGATACATACTCCTGAAGCATT
CTGAAGAGAACATAAACATTAAGAGTGCGCTGCTTCACGTGGCGACGGACACACTCGGTTCGGTTGCAGCGATAATAGCG
GGGATAGCGATCGTTTTCTGGAAGTTTTACCTTGCGGACCCAATTCTGAGCGTTGCTGTAGCCCTTTTAATCCTGCCTTC
CGCCTACTCGGTTATAAAGGAAACCGTAAACGTACTCCTTGAAGTTGCCCCTTCCCACATTAACACGGAAGAACTCGAAA
AGGAACTCTTGAACCTTCAAGGTGTAAAAGGCGTTCACGACCTTCACGTCTGGTCCATAACACCCGGAACGGAAGTACTT
ACGGTTCATGTGGTTGTTGAAGACACGAGTATATGCAACGACATATTGAAGGAAGTTGAAAAGATAGCCCACAAGTACGG
TATAAAACATACCACGGTACAGCTTGAAAAGGAAGGTTACGCCTGTGCCGAGTGCTGTCCCCTTCTCTCTCCTCAAGGGT
TAAAGTTCCATCACCACCATCACCACGGCCACGAGCACGAACACTGA

Upstream 100 bases:

>100_bases
TATACCCGTTGAAATAATCTACAACGTTGTTTTGAAGCTAAAGGGTATAGAGGAGAAAAATCAGTGATTTTAAAGGTTCT
AACCATAGAATAAAAAGCGT

Downstream 100 bases:

>100_bases
GTTAAATTATCTTTATGGAAAAGACTTATAAACTTCCCATAGTCTTGGGAACGGATCCCGAAAACACTATAAGGATTGAC
AAACTCCCTCCCCTTAAGGG

Product: cation efflux system (czcD-like)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MEREKSLKVLAFSFLLIFLFAFIEFLGGLLTNSLALLSDAGHMLTDAVSLSIALVAQYLALKVKTKRTTYGLYRLEVLAA
LVNGVFLLGLIGYIILEAIHRFENPEPVKPQMIYIAFAGLIVNLVVGYILLKHSEENINIKSALLHVATDTLGSVAAIIA
GIAIVFWKFYLADPILSVAVALLILPSAYSVIKETVNVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVL
TVHVVVEDTSICNDILKEVEKIAHKYGIKHTTVQLEKEGYACAECCPLLSPQGLKFHHHHHHGHEHEH

Sequences:

>Translated_308_residues
MEREKSLKVLAFSFLLIFLFAFIEFLGGLLTNSLALLSDAGHMLTDAVSLSIALVAQYLALKVKTKRTTYGLYRLEVLAA
LVNGVFLLGLIGYIILEAIHRFENPEPVKPQMIYIAFAGLIVNLVVGYILLKHSEENINIKSALLHVATDTLGSVAAIIA
GIAIVFWKFYLADPILSVAVALLILPSAYSVIKETVNVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVL
TVHVVVEDTSICNDILKEVEKIAHKYGIKHTTVQLEKEGYACAECCPLLSPQGLKFHHHHHHGHEHEH
>Mature_308_residues
MEREKSLKVLAFSFLLIFLFAFIEFLGGLLTNSLALLSDAGHMLTDAVSLSIALVAQYLALKVKTKRTTYGLYRLEVLAA
LVNGVFLLGLIGYIILEAIHRFENPEPVKPQMIYIAFAGLIVNLVVGYILLKHSEENINIKSALLHVATDTLGSVAAIIA
GIAIVFWKFYLADPILSVAVALLILPSAYSVIKETVNVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVL
TVHVVVEDTSICNDILKEVEKIAHKYGIKHTTVQLEKEGYACAECCPLLSPQGLKFHHHHHHGHEHEH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=322, Percent_Identity=29.8136645962733, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI20070323, Length=327, Percent_Identity=28.4403669724771, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI52352805, Length=305, Percent_Identity=25.9016393442623, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI21361112, Length=312, Percent_Identity=26.2820512820513, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI289803013, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803009, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803007, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803003, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI64762489, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI52351208, Length=158, Percent_Identity=34.1772151898734, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI14210520, Length=232, Percent_Identity=23.7068965517241, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI52352803, Length=180, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI222080086, Length=139, Percent_Identity=26.6187050359712, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40255009, Length=139, Percent_Identity=26.6187050359712, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786966, Length=289, Percent_Identity=39.1003460207612, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1790349, Length=243, Percent_Identity=25.1028806584362, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555796, Length=306, Percent_Identity=32.6797385620915, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555794, Length=306, Percent_Identity=32.6797385620915, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193210990, Length=306, Percent_Identity=29.7385620915033, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=32.1311475409836, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323899, Length=152, Percent_Identity=32.2368421052632, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=336, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=137, Percent_Identity=39.4160583941606, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656728, Length=363, Percent_Identity=30.0275482093664, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656724, Length=363, Percent_Identity=30.0275482093664, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656720, Length=363, Percent_Identity=30.0275482093664, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656715, Length=363, Percent_Identity=30.0275482093664, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357035, Length=363, Percent_Identity=30.0275482093664, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583858, Length=326, Percent_Identity=26.6871165644172, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585900, Length=149, Percent_Identity=28.8590604026846, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585898, Length=149, Percent_Identity=28.8590604026846, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585896, Length=149, Percent_Identity=28.8590604026846, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921672, Length=149, Percent_Identity=28.8590604026846, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24584409, Length=154, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574430, Length=154, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24645863, Length=107, Percent_Identity=39.2523364485981, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34009; Mature: 34009

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREKSLKVLAFSFLLIFLFAFIEFLGGLLTNSLALLSDAGHMLTDAVSLSIALVAQYLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LKVKTKRTTYGLYRLEVLAALVNGVFLLGLIGYIILEAIHRFENPEPVKPQMIYIAFAGL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IVNLVVGYILLKHSEENINIKSALLHVATDTLGSVAAIIAGIAIVFWKFYLADPILSVAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLILPSAYSVIKETVNVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEE
TVHVVVEDTSICNDILKEVEKIAHKYGIKHTTVQLEKEGYACAECCPLLSPQGLKFHHHH
EEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCC
HHGHEHEH
CCCCCCCC
>Mature Secondary Structure
MEREKSLKVLAFSFLLIFLFAFIEFLGGLLTNSLALLSDAGHMLTDAVSLSIALVAQYLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LKVKTKRTTYGLYRLEVLAALVNGVFLLGLIGYIILEAIHRFENPEPVKPQMIYIAFAGL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IVNLVVGYILLKHSEENINIKSALLHVATDTLGSVAAIIAGIAIVFWKFYLADPILSVAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLILPSAYSVIKETVNVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEE
TVHVVVEDTSICNDILKEVEKIAHKYGIKHTTVQLEKEGYACAECCPLLSPQGLKFHHHH
EEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCC
HHGHEHEH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]