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The map label for this gene is trpS

Identifier: 15606299

GI number: 15606299

Start: 684685

End: 685872

Strand: Direct

Name: trpS

Synonym: aq_992

Alternate gene names: 15606299

Gene position: 684685-685872 (Clockwise)

Preceding gene: 15606293

Following gene: 15606300

Centisome position: 44.14

GC content: 43.69

Gene sequence:

>1188_bases
ATGCGAATAGTTAGCGGAATGAGACCCACCGGGAAGCTCCATCTCGGACACTACTTCGGCGTTATAAGAAACTGGGTGAA
ACTTCAGGAAGAGCACGAGTGTTTTTTCTTCATAGCGGACTGGCATGCCCTTACCACCGCTTATAAAAACACCAAAGAAC
TCAGACAAAACATAAGGGAGGTTATGATAGATTGGCTCGCTCTGGGACTTGACCCTCAAAAAAGTGTCCTCTTTATTCAA
TCTCTCGTAAAAGAGCACGCGGAACTCTTTTTACTTTTCGGAATGATTACTCCAAAGAGCTGGCTGGAACTGAACCCGAC
TTACAAAGACCTAAAGTACAACCTTCTGAGACTCACGGATTTGGAAAAGGAGTTCAAAGAAAAATTGAAGGAAAGAATTT
CCGAAATCGTGAACCTCATTCCCTTTAATATAACTAAAGAAGAAAAATTCAGAGAGCACCTTCTTGAGAACTTAACACAG
ACCATGATAGAGGCACTCTTTGAGGGAGAGATTGAACCGGAGATTTTAAAAAGGCTCAACGTGTCTAAGAGGGATTTTTA
CGAAACGGATACCTTTGGATTTCTGGGATATCCAGTTCTACAAGCGGCGGACATACTCATTTACAAAGGCGAAGGTGTGC
CCGTGGGAGAGGATCAACTTCCTCACATAGAACTCTCCCGTGAAATAGCAAGAAGGTTTAACAGACTCTACGGAAAGATA
TTCCCAGAGCCAAAAGCCCTCCTGACAGAAACTCCCAAAATCCCCGGAACTGACGGAAGGAAGATGTCAAAATCTTACGG
AAACGCTGTTTTCTTCTCGGACGAAAAAGAAGAAGTGGAAAAGAAAGTGATGAAGATGTTCACGGACCCACAAAAGATAA
GAAAAAACGACCCCGGAAGACCCGAAATATGCCCCGTATTTTCCTGGCACAAGCTATTCACGAAAGATGAGGAACTCGTG
AAAAAGATAGAAGAGGACTGCAGAGCCGGAAGGCTGGGATGTGTAGAGTGCAAAAGGATACTCCTCAAACACCTTGAAGA
GTTTTTAGAACCCATAAGGGAAAGGAGAAGGGAACTTGAGAAGCGTATAAACGAAATAGAAGAGGTGTTTTACGAAAACT
CCCGAAAAGCCAGAGAGATAGCCCAGAAAACCATGGAAGAAGTGAGAAAAGCCATGAACCTTCCCTGA

Upstream 100 bases:

>100_bases
CGAAAAGTACTACCTTATGATCCTCGGTATCGTAAAGGATTTGCTCCGCCATAATTTATATGATAAAGCTCAAGAAAGGC
AAATTGTAAAATAATTTCCC

Downstream 100 bases:

>100_bases
TGGAATTTCTCTTACTTCCCTTTTTTCTTTTTATCCCCTACATTCTTTACTTCCTCTACCCGGTAAAGTTCATAAAAAAT
TTTAGAGAGGTGAACGAAGT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQ
SLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQ
TMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKI
FPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELV
KKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP

Sequences:

>Translated_395_residues
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQ
SLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQ
TMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKI
FPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELV
KKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
>Mature_395_residues
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQ
SLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQ
TMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKI
FPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELV
KKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=208, Percent_Identity=35.5769230769231, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI41352700, Length=97, Percent_Identity=43.298969072165, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789786, Length=87, Percent_Identity=40.2298850574713, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71982800, Length=208, Percent_Identity=32.6923076923077, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982793, Length=210, Percent_Identity=32.3809523809524, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320474, Length=214, Percent_Identity=35.0467289719626, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24666151, Length=216, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_AQUAE (O67115)

Other databases:

- EMBL:   AE000657
- PIR:   H70385
- RefSeq:   NP_213678.1
- ProteinModelPortal:   O67115
- SMR:   O67115
- GeneID:   1193749
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_992
- NMPDR:   fig|224324.1.peg.693
- HOGENOM:   HBG293263
- OMA:   IGCLECK
- BioCyc:   AAEO224324:AQ_992-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 46710; Mature: 46710

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
VMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHH
LEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
VSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKI
CCHHHCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
FPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGR
CCCCHHHHCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCCHHHHHCCCCCC
PEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELE
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
VMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHH
LEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
VSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKI
CCHHHCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
FPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGR
CCCCHHHHCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCCHHHHHCCCCCC
PEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELE
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320