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The map label for this gene is gyrA

Identifier: 15606292

GI number: 15606292

Start: 677905

End: 680139

Strand: Direct

Name: gyrA

Synonym: aq_980

Alternate gene names: 15606292

Gene position: 677905-680139 (Clockwise)

Preceding gene: 15606290

Following gene: 15606293

Centisome position: 43.7

GC content: 44.74

Gene sequence:

>2235_bases
ATGGAAAACAGGGAAAACCTCGTGGAAATTCCCATAGAGGAAGAGGTAAAACAGGCATACATAGACTACGCAATGTCCGT
AATAGTCGGGAGGGCAATTCCCGACGTAAGGGACGGACTAAAACCTGTTCAAAGGAGAATCCTCTACTCCATGTACGAAA
TGGGACTGCTTCCCGATAAGCCCTTTAAGAAGAGTGCGAGAATAGTTGGCGAAACTTTGGGTAAGTACCACCCCCACGGC
GATCAGGCGGTTTATGAAGCGTTAGTTAGAATGGCTCAGGACTTTACCATGAGATACCCCCTGATAATAGGTCAGGGGAA
TTTCGGTTCCATAGACGGTGATCCGGCGGCTCAGATGCGCTATACGGAGGCAAAACTCTCACCCCTCGCCGTTGAAATGC
TTACGGACATAGATAAAGATACGGTAGACTTCCAACCTAACTTTGACGATACACTGATGGAACCCGAAGTGCTTCCTTCA
AAGTTTCCAAACTTGCTTTGCAACGGCACAAGCGGTATAGCGGTAGGACTCGCTACATCAATACCACCCCACAACTTAAC
AGAAGTGGGAAATGCTCTGGTGAAACTCGCCCAGAATCCCCAGATATCCGTGGACGAAATTATGGAAATACTGAAAGGTC
CTGACTTTCCCACAGGAGGAGTGATAGAAAACTTTGCGCAGGTGAAGGAAATATACAAAACCGGAAGGGGAATAATAAAG
GTTAAAGGGAAAGCTCACGTTGAGAAAGTTCAAGGAGGAAGGGAAAGGATAGTTATAACGGAAATTCCTTATCAGGTGAA
CAAGGCAGAACTCATAAAGAAAATTGCGGACAACGTAAGGAACGGAAAGATTAAAGAAATCTCAGACATAAGGGACGAAA
CGGACAAGGAGGGAATCAGGATAGTTGTAGAGCTTAAGAGGGACGCAAAAGGCGAAGAGGTTCTCAAAAAACTCTACAAG
TACACCCCACTTGAGAAAGGTTTCCCCGTAAACCTCGTAGTTCTAATAGACAAAGAACCTAAACTCGTTGACATAAAAAC
GCTTCTCAGGGAGTTCATAAAGCACAGACTGGAAGTAATACTCAGGCGATCTAAGTACTTCCTCAAGAAAGTTCAAGACA
GACTCCACATAGTAGAGGGACTGCTAAAAGCCATAAACTTCATAGACGACATAATAGAAAGGATAAGAAGGTCAAAAGAC
GCGTCAGAGGCGAGGAATTATTTAATGGAAGAATTCGGGCTCTCTGAAAAGCAGGCTCAGGCGGTTCTGGACCTCAGACT
CCAGCGTCTTACATCCTTAGAGAGGGAAAAACTCCTTGAAGAAGAAAAGGAACTGAGGGAAAAGATTGAGTACTACAAGA
AACTCGTTGCGAGCGAAGGCGAGAGGATAAAGGTCTTCATTGAGGAGACCGAAGAACTCGTAAAGAAGTACGGAGACAAG
AGAAGAACCTTCATAGGTGGTGTAAAGGAAGTAAAGGAAGGTTCAATTACGGTTGCAGTTCTTCAGGACGGCTCTATAAT
TCCCGTGGAAGAATTGCCTCTTGAAAAAGCTCCAGTTGTGAACATACTCAGAGTTCCCTTTACGGAAGGTCTCTTCTTGG
TTTCAAATAGAGGAAGAGTTTACTGGATTGCGGGTTCTCAGGCACTTCAGGGCAGTAAAGTATCTCTAAAATCAAGGGAA
GAAAAAATAGTAGGTGCATTCATAAGGGAAAAATTCGGAAACAGATTGCTCCTTGCAACCAAGAAAGGATACGTGAAGAA
GATTCCGCTTGCCGAGTTTGAGTACAAAGCTCAGGGAATGCCCATAATAAAGCTAACAGAAGGGGACGAAGTCGTAAGTA
TAGCTAGTTCCGTTGACGAAACACACATACTCCTCTTCACAAAAAAAGGAAGAGTTGCACGCTTCAGTGTGAGAGAAGTT
CCACCCTCCACTCCCGGGGCAAGGGGCGTTCAGGGGATAAAACTCGAAAAGAACGATGAAACCTCTGGGCTAAGGATATG
GAACGGCGAACCATACCTCCTCGTCATAACCGCAAAAGGCAGAGTTAAAAAGATTTCCCACGAGGAAATCCCGAAAACCA
ACAGAGGTGTTAAGGGAACGGAAGTATCGGGAACTAAAGACACGCTCGTTGACCTTATCCCTATAAAGGAGGAAGTAGAA
CTCCTTATAACGACAAAAAACGGAAAAGCCTTCTACGGACAAAATCAACCAGAAAGACATACCACTTTCTACTAA

Upstream 100 bases:

>100_bases
GGCTATCCTTAAAAGATTTGTGTGAGATTTATCAAGGAAGAAAAATAACGATTTATGAATAACTTATAAAACCAAGCTCT
TCTGTGGTATAATTGCCTTT

Downstream 100 bases:

>100_bases
AAAGAGCATCCCAAGGACACGCTGGAAGCTGGAGGACGACGAAATAATTAAAGTGGTAATAAAGAAAAGCGAATGAACGT
AGTTTTATCGCTCGAGACGT

Product: DNA gyrase A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHG
DQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPS
KFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIK
VKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYK
YTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKD
ASEARNYLMEEFGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDK
RRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRVYWIAGSQALQGSKVSLKSRE
EKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREV
PPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVE
LLITTKNGKAFYGQNQPERHTTFY

Sequences:

>Translated_744_residues
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHG
DQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPS
KFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIK
VKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYK
YTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKD
ASEARNYLMEEFGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDK
RRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRVYWIAGSQALQGSKVSLKSRE
EKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREV
PPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVE
LLITTKNGKAFYGQNQPERHTTFY
>Mature_744_residues
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHG
DQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPS
KFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIK
VKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYK
YTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKD
ASEARNYLMEEFGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDK
RRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRVYWIAGSQALQGSKVSLKSRE
EKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREV
PPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVE
LLITTKNGKAFYGQNQPERHTTFY

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913408, Length=351, Percent_Identity=26.2108262108262, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19913406, Length=351, Percent_Identity=26.2108262108262, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1788562, Length=760, Percent_Identity=41.8421052631579, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789396, Length=742, Percent_Identity=35.5795148247978, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=505, Percent_Identity=24.950495049505, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535065, Length=438, Percent_Identity=24.2009132420091, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=399, Percent_Identity=25.062656641604, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136538, Length=368, Percent_Identity=26.3586956521739, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GYRA_AQUAE (O67108)

Other databases:

- EMBL:   AE000657
- PIR:   A70385
- RefSeq:   NP_213671.1
- ProteinModelPortal:   O67108
- SMR:   O67108
- GeneID:   1193742
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_980
- NMPDR:   fig|224324.1.peg.686
- HOGENOM:   HBG635183
- OMA:   ERINIFI
- ProtClustDB:   CLSK2299574
- BioCyc:   AAEO224324:AQ_980-MONOMER
- BRENDA:   5.99.1.3
- GO:   GO:0005694
- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- Gene3D:   G3DSA:1.10.268.10
- SMART:   SM00434
- TIGRFAMs:   TIGR01063

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: =5.99.1.3

Molecular weight: Translated: 84082; Mature: 84082

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDK
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMR
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCCHHHEE
YTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATS
EHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEECCCCCEEEEEECC
IPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIK
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIR
ECCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEE
IVVELKRDAKGEEVLKKLYKYTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVI
EEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHH
LRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKDASEARNYLMEEFGLSEKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
AVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCC
RRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRV
HHHHHCCHHHHCCCCEEEEEECCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEECCCEE
YWIAGSQALQGSKVSLKSREEKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGM
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCHHHHHHCCCC
PIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREVPPSTPGARGVQGIKLEKNDE
CEEEECCCCHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEECCCC
TSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVE
CCCEEEECCCCEEEEEECCCCCEECCHHHCCCCCCCCCCCCCCCCHHHHHEEECCCCCEE
LLITTKNGKAFYGQNQPERHTTFY
EEEEECCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDK
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMR
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCCHHHEE
YTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATS
EHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEECCCCCEEEEEECC
IPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIK
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIR
ECCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEE
IVVELKRDAKGEEVLKKLYKYTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVI
EEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHH
LRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKDASEARNYLMEEFGLSEKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
AVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCC
RRTFIGGVKEVKEGSITVAVLQDGSIIPVEELPLEKAPVVNILRVPFTEGLFLVSNRGRV
HHHHHCCHHHHCCCCEEEEEECCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEECCCEE
YWIAGSQALQGSKVSLKSREEKIVGAFIREKFGNRLLLATKKGYVKKIPLAEFEYKAQGM
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCHHHHHHCCCC
PIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREVPPSTPGARGVQGIKLEKNDE
CEEEECCCCHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEECCCC
TSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGTEVSGTKDTLVDLIPIKEEVE
CCCEEEECCCCEEEEEECCCCCEECCHHHCCCCCCCCCCCCCCCCHHHHHEEECCCCCEE
LLITTKNGKAFYGQNQPERHTTFY
EEEEECCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320