Click here to switch to the map view.

The map label for this gene is napA2 [H]

Identifier: 15606256

GI number: 15606256

Start: 641743

End: 642969

Strand: Direct

Name: napA2 [H]

Synonym: aq_929

Alternate gene names: 15606256

Gene position: 641743-642969 (Clockwise)

Preceding gene: 15606255

Following gene: 15606257

Centisome position: 41.37

GC content: 44.82

Gene sequence:

>1227_bases
ATGGCAGCGGCACCGGTAGAGGGAAATGGGGCAGGATTAGACGTCCATACTTTATTTTTGCACTTAGCTATACTCCTATT
TTCCGCAAAGCTTTTCGGTTCGATATTCAGGAAACTAGGTATCCCTCCCGTCCTCGGAGAGGTCACAGCGGGTGTAATTC
TCGGTCAGAGCGTACTTGGGTTAATTCCGCTCTCGGAAGCAATAAAGGTCCTTGCGGAACTCGGTGTAATACTCCTACTC
TTCGAAGTAGGTCTTGAAGCCGACATAAATATGTTAATGAGAGTGGGCCTTTGGTCCACTTTAGTCGCAATAGTTGGAGC
AGCACTTCCCTTTGCGGGAGGGTTTATAGTTTCCTACTACTTCTTCGGTCTTGATCTCGTGGCTTCACTCTTTATGGGAG
GGGCACTTACCGCAACGAGCATAGGTATAACGGTAAGGGTTTTAACCGATTTGAATAAACACAAAGAACGTTTTGCTCAG
ATAGTCCTCGGTGCGGCAGTTCTGGACGATATTATGGGTGTTATAATCCTCGCAGCTTTGTACGAATTTTCAAAAACGAA
GGCAGTTCATTTTGACACCACGGTTAATCTGATAATACACATCTTGATGTTCTTCCTTATAGCTCCCTTCGTTGCAAACG
TCTTAGCAAAACTCCTTTCCATAGCTGCGAGGAAGACTCAGGACATGGATTTAATCCCTGCTTCTATAATGGCTCTTATA
CTACTCGCAGCTTATTCAGCTCATAAATTCGGTTCTCCGAGTATTCTCGGTTCTTTTACCGCAGGACTTGCCCTCTCGAG
GAGATTCGTAATCCCCTTTGCCGCTATGCTCCGTTTGGACGAAAAATTGCTTCACAAGGTTGAGGAGTCAATAACTCCCC
TTGTATGGGTAATGGCTCCTATATTCTTCGTTTCCGTAGGACTTGCACTTAACTTAAAAGCTATAGACTTTTCCTCTCCG
GAGTTCTGGACCTTTTCTTCAGCACTTATAGTAGTAGCGATAATAGGAAAAGTTCTGGCGGGTTTCGTAGCTCCGGGTTC
ATTGAAGGAAAAGGCAAGCATAGGCTTTTCCATGCTCCCCCGTGGAGAAGTGGGATTGATATTTGCCGAGTTCGGAAGGA
GCTTTAAAGCTATAAACGAGGTAGAGTACGCAGTTATCGTTTTCGTCGTGGCTGTTACAACGTTAATAGCCCCGATAGTT
CTTAAACTTCTTTTAAAAGAAGAATAG

Upstream 100 bases:

>100_bases
ACGTCAATTATGAAAAGTACAGACCAATAGGAAGGCTCGGGGGGAAGTACTATGTTAAAGCTTTTGGAGAATGTAAGTTG
AAGGTATAATAAGCCGTATT

Downstream 100 bases:

>100_bases
ATGGAATGGGGGCATGTTTTAACAATAATTTTTGGCACAGCAGGGTTTATAGGCTCAGTAAAAGGATAGACAGCGTTGAG
AAAAGGATAGACGATTTAAA

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MAAAPVEGNGAGLDVHTLFLHLAILLFSAKLFGSIFRKLGIPPVLGEVTAGVILGQSVLGLIPLSEAIKVLAELGVILLL
FEVGLEADINMLMRVGLWSTLVAIVGAALPFAGGFIVSYYFFGLDLVASLFMGGALTATSIGITVRVLTDLNKHKERFAQ
IVLGAAVLDDIMGVIILAALYEFSKTKAVHFDTTVNLIIHILMFFLIAPFVANVLAKLLSIAARKTQDMDLIPASIMALI
LLAAYSAHKFGSPSILGSFTAGLALSRRFVIPFAAMLRLDEKLLHKVEESITPLVWVMAPIFFVSVGLALNLKAIDFSSP
EFWTFSSALIVVAIIGKVLAGFVAPGSLKEKASIGFSMLPRGEVGLIFAEFGRSFKAINEVEYAVIVFVVAVTTLIAPIV
LKLLLKEE

Sequences:

>Translated_408_residues
MAAAPVEGNGAGLDVHTLFLHLAILLFSAKLFGSIFRKLGIPPVLGEVTAGVILGQSVLGLIPLSEAIKVLAELGVILLL
FEVGLEADINMLMRVGLWSTLVAIVGAALPFAGGFIVSYYFFGLDLVASLFMGGALTATSIGITVRVLTDLNKHKERFAQ
IVLGAAVLDDIMGVIILAALYEFSKTKAVHFDTTVNLIIHILMFFLIAPFVANVLAKLLSIAARKTQDMDLIPASIMALI
LLAAYSAHKFGSPSILGSFTAGLALSRRFVIPFAAMLRLDEKLLHKVEESITPLVWVMAPIFFVSVGLALNLKAIDFSSP
EFWTFSSALIVVAIIGKVLAGFVAPGSLKEKASIGFSMLPRGEVGLIFAEFGRSFKAINEVEYAVIVFVVAVTTLIAPIV
LKLLLKEE
>Mature_407_residues
AAAPVEGNGAGLDVHTLFLHLAILLFSAKLFGSIFRKLGIPPVLGEVTAGVILGQSVLGLIPLSEAIKVLAELGVILLLF
EVGLEADINMLMRVGLWSTLVAIVGAALPFAGGFIVSYYFFGLDLVASLFMGGALTATSIGITVRVLTDLNKHKERFAQI
VLGAAVLDDIMGVIILAALYEFSKTKAVHFDTTVNLIIHILMFFLIAPFVANVLAKLLSIAARKTQDMDLIPASIMALIL
LAAYSAHKFGSPSILGSFTAGLALSRRFVIPFAAMLRLDEKLLHKVEESITPLVWVMAPIFFVSVGLALNLKAIDFSSPE
FWTFSSALIVVAIIGKVLAGFVAPGSLKEKASIGFSMLPRGEVGLIFAEFGRSFKAINEVEYAVIVFVVAVTTLIAPIVL
KLLLKEE

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=393, Percent_Identity=26.4631043256997, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=356, Percent_Identity=27.8089887640449, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43583; Mature: 43452

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAAPVEGNGAGLDVHTLFLHLAILLFSAKLFGSIFRKLGIPPVLGEVTAGVILGQSVLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LIPLSEAIKVLAELGVILLLFEVGLEADINMLMRVGLWSTLVAIVGAALPFAGGFIVSYY
HCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFGLDLVASLFMGGALTATSIGITVRVLTDLNKHKERFAQIVLGAAVLDDIMGVIILAAL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEFSKTKAVHFDTTVNLIIHILMFFLIAPFVANVLAKLLSIAARKTQDMDLIPASIMALI
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LLAAYSAHKFGSPSILGSFTAGLALSRRFVIPFAAMLRLDEKLLHKVEESITPLVWVMAP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFFVSVGLALNLKAIDFSSPEFWTFSSALIVVAIIGKVLAGFVAPGSLKEKASIGFSMLP
HHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
RGEVGLIFAEFGRSFKAINEVEYAVIVFVVAVTTLIAPIVLKLLLKEE
CCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]