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The map label for this gene is speC [H]

Identifier: 15606123

GI number: 15606123

Start: 505654

End: 506826

Strand: Direct

Name: speC [H]

Synonym: aq_728

Alternate gene names: 15606123

Gene position: 505654-506826 (Clockwise)

Preceding gene: 15606122

Following gene: 15606124

Centisome position: 32.59

GC content: 44.5

Gene sequence:

>1173_bases
ATGACTAAGGTTGTAAATTACGGGGAAGTTCAGTACGGTTTTGCTAAGAGGTACTTTGAAGAATTCTTATCCGAGAGGAA
AGGAAGGATAGAAAAGCTCTTGAAACCAGAAAAAACTCCGGTTCTCCTTATGGACATCCAGGGTGTGAAGAAAAAGTACC
TCGAAGTTAAGTATCACTTTCCCGAGTTTAACGTTTACTACGCGGTTAAGGCAAATGACGACGAAAGCGTTATAAGGGCT
CTCGTTGAAGTGGGAGCAGGATTTGAGGTTGCCTCTTCTCAGGAACTTGAAAAGGTTCTGAGGCTTGGAGGAAAAATTGA
AAAAGTAATTTCAAGTAATCCAGTAAAACCTCCAGAATTTATAGAGTTTGCGTATCAGAAGGGTGTTAGAACCTTCGCGG
TGGATAGCATAACGGAAGTTAAAAAAATTAAAGATATTGCCCCGCGTTCAAAAGTTTACGTGAGGATTGCCGTTCCGAAT
GAAGGAAGCGACTGGCCCCTTTCCCGGAAGTTTGGAGTGAGTGTGGAAGAAGCCGTTGAAATTCTAGAGTACGCAAATGA
CCTTGGACTCGTCCCTTACGGGATTACCTTTCACGTGGGTTCTCAGTGTAATAACTTAAGAAACTGGTTCATAGCGGTAA
AGCTTTCTGCACAACTCTGGGAAAAGGCAAGGGCAAAGGGACTAAAGCTTCAGATGCTCAACATGGGCGGGGGAATTCCC
GTTCGTTACAACTACGAAGCTCTGAGCGTTGAGGACATAGCCTATTACGTCAAAGGACTCATGAGGAAGTACTTTCCTGT
TCAACCTTATGAACTGCAGATAGAACCCGGAAGGGGAATAGTCGGAGATCAGGGAATTATGGTAACAAAGGTAATAGGGA
AAGCTAAGAGAGGAAGTGAAAACTGGCTTTACATAGACACTGGAGTTTTTAACGGACTTGCGGAAGCACTCGGGGGCATA
AGGTATCCCTTCTTCCTTGAAAGGGAAGGGGAACTGAAGGAGTGGACAATAGGCGGTGTTTCCTGCGACAGTATGGACGT
AGTGGCTAAGAACGTTTACCTTCCAGAACCTGAAGTAGGTGATTACCTTTACATACTTTCCGCTGGAGCTTACACCACCG
TTTACGCTTCAAACTTCAACGGCTTTCCTAAACCTGAGGTTGTTCCTTTTTAG

Upstream 100 bases:

>100_bases
TTAAAGCGTTCGTGAAAGGAGATCTGGAACAAATAAAGGGGAACTTTGTTGTAGGTCCTTCCTGAAGCAAATATCTATAA
AAGTATTTATATTTATCGGA

Downstream 100 bases:

>100_bases
AAATAAATTCAATCTTATGAATAAGTACCCCTCTTATTTGAACCTCTATGAGAGCGGAGAGCTGGAAAAGAGGGTGGAAA
AAGCCCTTAATATGCTTGAA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHFPEFNVYYAVKANDDESVIRA
LVEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEFIEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPN
EGSDWPLSRKFGVSVEEAVEILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIP
VRYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSENWLYIDTGVFNGLAEALGGI
RYPFFLEREGELKEWTIGGVSCDSMDVVAKNVYLPEPEVGDYLYILSAGAYTTVYASNFNGFPKPEVVPF

Sequences:

>Translated_390_residues
MTKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHFPEFNVYYAVKANDDESVIRA
LVEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEFIEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPN
EGSDWPLSRKFGVSVEEAVEILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIP
VRYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSENWLYIDTGVFNGLAEALGGI
RYPFFLEREGELKEWTIGGVSCDSMDVVAKNVYLPEPEVGDYLYILSAGAYTTVYASNFNGFPKPEVVPF
>Mature_389_residues
TKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHFPEFNVYYAVKANDDESVIRAL
VEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEFIEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPNE
GSDWPLSRKFGVSVEEAVEILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIPV
RYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSENWLYIDTGVFNGLAEALGGIR
YPFFLEREGELKEWTIGGVSCDSMDVVAKNVYLPEPEVGDYLYILSAGAYTTVYASNFNGFPKPEVVPF

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=372, Percent_Identity=29.3010752688172, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI16506287, Length=393, Percent_Identity=26.972010178117, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI22538418, Length=371, Percent_Identity=26.9541778975741, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI21361583, Length=371, Percent_Identity=26.9541778975741, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789203, Length=393, Percent_Identity=25.4452926208651, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789307, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562780, Length=396, Percent_Identity=29.7979797979798, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25141365, Length=356, Percent_Identity=23.314606741573, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25141367, Length=204, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=394, Percent_Identity=28.9340101522843, Blast_Score=156, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24586472, Length=388, Percent_Identity=30.4123711340206, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24586474, Length=386, Percent_Identity=29.2746113989637, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43952; Mature: 43821

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCEEEEEEEEC
PEFNVYYAVKANDDESVIRALVEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEF
CCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHH
IEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPNEGSDWPLSRKFGVSVEEAVE
HHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
ILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIP
HHHHHHHCCCCEEEEEEEECCHHCCCCEEEEEEEECHHHHHHHHHCCCEEEEEECCCCCC
VRYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSE
EEECCCEECHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCEEEEEHHHHCCCCCC
NWLYIDTGVFNGLAEALGGIRYPFFLEREGELKEWTIGGVSCDSMDVVAKNVYLPEPEVG
CEEEEECHHHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHEECCCCCCC
DYLYILSAGAYTTVYASNFNGFPKPEVVPF
CEEEEEECCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCEEEEEEEEC
PEFNVYYAVKANDDESVIRALVEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEF
CCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHH
IEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPNEGSDWPLSRKFGVSVEEAVE
HHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
ILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIP
HHHHHHHCCCCEEEEEEEECCHHCCCCEEEEEEEECHHHHHHHHHCCCEEEEEECCCCCC
VRYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSE
EEECCCEECHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCEEEEEHHHHCCCCCC
NWLYIDTGVFNGLAEALGGIRYPFFLEREGELKEWTIGGVSCDSMDVVAKNVYLPEPEVG
CEEEEECHHHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHEECCCCCCC
DYLYILSAGAYTTVYASNFNGFPKPEVVPF
CEEEEEECCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]