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The map label for this gene is thy

Identifier: 15606066

GI number: 15606066

Start: 438038

End: 438991

Strand: Direct

Name: thy

Synonym: aq_640

Alternate gene names: 15606066

Gene position: 438038-438991 (Clockwise)

Preceding gene: 15606063

Following gene: 15606069

Centisome position: 28.24

GC content: 42.35

Gene sequence:

>954_bases
TTGATGAAAATCTACTTAATGGGCTCGGACCAGAGGATAGTTAGGTGTGCGAGGGTGTCCTTTGCAAAGGACTCATATGT
CGATGAAAAGAGGGACAAAAGACTCATTCGCTACCTCTTCAAGCACAGGCACGCGTCTCCCTTTGAGCACAACATCATTG
CCTTTGAGTGGAAAAAGGAGAAGTGGATAGAACTCCTTTCAAAGCTGGAAAACCCTACCGTTCAGGTTTACTACTCAAAT
GGCTTTGTTTTTCTTAACTTAAGGAACGCTATCAACGTATGGGAACTTTTGCCCGACGCAGTCAAAGAAAGGATAAAGGA
GGCTTTTCCTACCACTTACGGAGTAATTCAGCGGAGAGGGGAAATTGAGGATGAGGAACTTTATTCCCTTCCCTACACTA
AAGATAAAGCTTACGTAAAGGAAAAGATTGAGACGAGTTCTGGCTGGATCGGGCTTGTTGATAAGCTGGAACTGGAAACT
GATATGGATTTTTACACTTTTGTGGTTGAATGCCCTCTTTTTGTAGCCCGTCAGTGGATGAGGCACAGGTTCGGCTCTTA
CAACGAGGTTTCTAAAAGGTACGTGGGAAAGGAGTTTCTGGAATTTTATCTCCCTAAATACATAAGAAAGCAAGCGGAGA
AAAACAAACAGGCTTCTGTGGATGAACCTATTTCTGAGAGTGAAGTTTTTATAAAAAAAATAGAAAATTTGATAAGCAAA
AGCGTAAAGCTCTACGAGGAGATAATAGAAAAGGGCGGTGCAAAAGAGCTCGCAAGGGGAGTGCTTCCCCAGTTTATGAA
AACGAGGTTTTACTGGACCGTTCCGAGGATTTCTCTTGACAACTTCATAACCCTCAGAACTCACGAAGGTGCACAAAAAG
AGATAAGGGAATTTGCAGAAGCTATAAAGGAAATGGTAGGATACAGGGGAACTGATAAGAAGAACGTCATTTAA

Upstream 100 bases:

>100_bases
TTCTTTCACCTCCTTAATAAGGAGTTTAATATATAAGAATGTTTAAAATCATCTAAAAAGATTTAATGGTAGTATAAACG
GAACTTATAAAATACTTTCT

Downstream 100 bases:

>100_bases
AATTTGCTCTATCAAGAAATCCCTTGAGTTCTTACAATTTTCTCTTTTTCGTCAACTTCAAAAATCTTTCCCAGAAACTG
TTCACAAACCCATATATTTG

Product: thymidylate synthase complementing protein

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKEKWIELLSKLENPTVQVYYSN
GFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELET
DMDFYTFVVECPLFVARQWMRHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISK
SVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAEAIKEMVGYRGTDKKNVI

Sequences:

>Translated_317_residues
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKEKWIELLSKLENPTVQVYYSN
GFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELET
DMDFYTFVVECPLFVARQWMRHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISK
SVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAEAIKEMVGYRGTDKKNVI
>Mature_317_residues
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKEKWIELLSKLENPTVQVYYSN
GFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELET
DMDFYTFVVECPLFVARQWMRHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISK
SVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAEAIKEMVGYRGTDKKNVI

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_AQUAE (O66883)

Other databases:

- EMBL:   AE000657
- PIR:   G70356
- RefSeq:   NP_213443.1
- ProteinModelPortal:   O66883
- SMR:   O66883
- GeneID:   1193945
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_640
- NMPDR:   fig|224324.1.peg.458
- OMA:   DEPISES
- ProtClustDB:   CLSK2748335
- BioCyc:   AAEO224324:AQ_640-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 37643; Mature: 37643

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHH
KWIELLSKLENPTVQVYYSNGFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRG
HHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
EIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELETDMDFYTFVVECPLFVARQWM
CCCHHHHEECCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
SVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCHHHHHHHHHH
AIKEMVGYRGTDKKNVI
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHH
KWIELLSKLENPTVQVYYSNGFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRG
HHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
EIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELETDMDFYTFVVECPLFVARQWM
CCCHHHHEECCCCCHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
SVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCHHHHHHHHHH
AIKEMVGYRGTDKKNVI
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320