Click here to switch to the map view.

The map label for this gene is xanB [H]

Identifier: 15606035

GI number: 15606035

Start: 400746

End: 402107

Strand: Direct

Name: xanB [H]

Synonym: aq_589

Alternate gene names: 15606035

Gene position: 400746-402107 (Clockwise)

Preceding gene: 15606033

Following gene: 15606036

Centisome position: 25.83

GC content: 43.98

Gene sequence:

>1362_bases
ATGAAAATACTTATACTGAGTGGGGGAAAGGGAACTAGACTGTGGCCACTTTCTAGGGAAAACTTCCCCAAGCAGTTCAT
AAGGTTGTTTTCAAAACACTCCCTCTTTCAAGAAACCGTAAAAAGAGCGAAAAAGCTCGCAAAAGACGAGGATATAGTTG
TTATAACGGGAGAAAAGTACGAGTGGATTATCAGAAGTGAACTTGAAGAGATAGATGCCAACGAAGTTCGGGTGGTGGTA
GAACCGGAGGGCAGAAACACAGCTCCCGCCATAGCCTTGGGAGTAAAGTACCTGATCCACAGCGAAACACCGCCTTCCGA
GACCGTTCTAGTTCTTCCCTCCGATCACCTGATAAAAGACACGGAAAAGTTCGTAGAAGCGGTAAAAAAGGGAGAAAAGT
ATGCAAAGGAGGGATACATAGTACTCTTCGGAGAAAAACCCACTTACCCTGAAACGGGATACGGATACATAAGGCTTAAC
GGAAAGCTAGAAGAAGGAGTTTACGAGATAGAGAAGTTTGAAGAAAAACCTGACTACGAAAAAGCTAAAGAGTACGTATC
CGACGGGAAGCACTTCTGGAACTGCGGGATATTCCTCTTCACCCTTGACAGAATAGTAAAAGACTACACTCAGTTAATGC
CCGAAATTCCCTTCCACGAGAAGTGGGAAGACTTTATTAAAGACTTTAAAAACTTTGAAGAAATTTCCTTTGATTACGCA
ATACTCGAACGGACGAAGAAGCTCGCCGTTGTAAAAATGGATGCCGGATGGAGTGACGTGGGTTCCTGGAAGGCGGTTTA
CGACAACTTGCCCAAAGACGAAAAGAGGAACGTCCTGATAGGTGATGTAAAGGCTATGGATACTGAGTGTTCCCTCCTTC
TCTCTCAAGGGAAAAACTTAATCGCGTGCATAGGACTTGAGGACTTCGTGGTGGTTGGGACTGAGGACGCCACGCTTATA
GTGAAGAGGGATTACTCTCAGAAGGTAAAAGAAATAGTAAAGGAACTCGAAGAGGAAAATGACGAGAGAGCAATAGAGCA
CGTGACTTCCTTCACACCTTTCGGGAGTATAACCAAACTCGATAGAGGCGAAAGGTACAAGATAAGAAAAGTAGTTGTAA
AAAAGGATAAGGAAATACCTTTGAGGATGCACCACCACAGAACTGTTCACTTCGTCGTCCTTAAGGGAACAGCGAAAGTA
AAGGTAGGGGATAAGGAGGAGTTCGTCCACGAGAACGAGAGTTTCTTCGTTCCTAAATCAACACCCTATAAAATAATAAA
CGTCGGGAAAATTCCCCTTGAGATGATAGAAGTTCAAAGCGGTGAATACTTAGGAGAGGACGATGTTGAAACACTTGAGT
GA

Upstream 100 bases:

>100_bases
CTATGTCCCACTCTCCTTCCTTTTCTGGAATCAGGACGTTTTTTATCAAAAGATCGTACTTCTCCATAGGGGATAATTTT
AAACTGCTAAAATTCTAAGT

Downstream 100 bases:

>100_bases
AAAGTTCATCTACTACATGGCGGAGTACTTCTTTGAGTTTGAAAAGAGGAAACACTACTACAAGCTCGCCAACAACCTTT
ACAACTCCTACCTGAAGGGC

Product: mannose-6-phosphate isomerase/mannose-1-phosphate guanyl transferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKILILSGGKGTRLWPLSRENFPKQFIRLFSKHSLFQETVKRAKKLAKDEDIVVITGEKYEWIIRSELEEIDANEVRVVV
EPEGRNTAPAIALGVKYLIHSETPPSETVLVLPSDHLIKDTEKFVEAVKKGEKYAKEGYIVLFGEKPTYPETGYGYIRLN
GKLEEGVYEIEKFEEKPDYEKAKEYVSDGKHFWNCGIFLFTLDRIVKDYTQLMPEIPFHEKWEDFIKDFKNFEEISFDYA
ILERTKKLAVVKMDAGWSDVGSWKAVYDNLPKDEKRNVLIGDVKAMDTECSLLLSQGKNLIACIGLEDFVVVGTEDATLI
VKRDYSQKVKEIVKELEEENDERAIEHVTSFTPFGSITKLDRGERYKIRKVVVKKDKEIPLRMHHHRTVHFVVLKGTAKV
KVGDKEEFVHENESFFVPKSTPYKIINVGKIPLEMIEVQSGEYLGEDDVETLE

Sequences:

>Translated_453_residues
MKILILSGGKGTRLWPLSRENFPKQFIRLFSKHSLFQETVKRAKKLAKDEDIVVITGEKYEWIIRSELEEIDANEVRVVV
EPEGRNTAPAIALGVKYLIHSETPPSETVLVLPSDHLIKDTEKFVEAVKKGEKYAKEGYIVLFGEKPTYPETGYGYIRLN
GKLEEGVYEIEKFEEKPDYEKAKEYVSDGKHFWNCGIFLFTLDRIVKDYTQLMPEIPFHEKWEDFIKDFKNFEEISFDYA
ILERTKKLAVVKMDAGWSDVGSWKAVYDNLPKDEKRNVLIGDVKAMDTECSLLLSQGKNLIACIGLEDFVVVGTEDATLI
VKRDYSQKVKEIVKELEEENDERAIEHVTSFTPFGSITKLDRGERYKIRKVVVKKDKEIPLRMHHHRTVHFVVLKGTAKV
KVGDKEEFVHENESFFVPKSTPYKIINVGKIPLEMIEVQSGEYLGEDDVETLE
>Mature_453_residues
MKILILSGGKGTRLWPLSRENFPKQFIRLFSKHSLFQETVKRAKKLAKDEDIVVITGEKYEWIIRSELEEIDANEVRVVV
EPEGRNTAPAIALGVKYLIHSETPPSETVLVLPSDHLIKDTEKFVEAVKKGEKYAKEGYIVLFGEKPTYPETGYGYIRLN
GKLEEGVYEIEKFEEKPDYEKAKEYVSDGKHFWNCGIFLFTLDRIVKDYTQLMPEIPFHEKWEDFIKDFKNFEEISFDYA
ILERTKKLAVVKMDAGWSDVGSWKAVYDNLPKDEKRNVLIGDVKAMDTECSLLLSQGKNLIACIGLEDFVVVGTEDATLI
VKRDYSQKVKEIVKELEEENDERAIEHVTSFTPFGSITKLDRGERYKIRKVVVKKDKEIPLRMHHHRTVHFVVLKGTAKV
KVGDKEEFVHENESFFVPKSTPYKIINVGKIPLEMIEVQSGEYLGEDDVETLE

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=463, Percent_Identity=38.2289416846652, Blast_Score=312, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 52268; Mature: 52268

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILILSGGKGTRLWPLSRENFPKQFIRLFSKHSLFQETVKRAKKLAKDEDIVVITGEKY
CEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCE
EWIIRSELEEIDANEVRVVVEPEGRNTAPAIALGVKYLIHSETPPSETVLVLPSDHLIKD
EEHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHEEECCCCCCCEEEECCCCHHHHH
TEKFVEAVKKGEKYAKEGYIVLFGEKPTYPETGYGYIRLNGKLEEGVYEIEKFEEKPDYE
HHHHHHHHHHCHHHHHCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHH
KAKEYVSDGKHFWNCGIFLFTLDRIVKDYTQLMPEIPFHEKWEDFIKDFKNFEEISFDYA
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHH
ILERTKKLAVVKMDAGWSDVGSWKAVYDNLPKDEKRNVLIGDVKAMDTECSLLLSQGKNL
HHHHCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCE
IACIGLEDFVVVGTEDATLIVKRDYSQKVKEIVKELEEENDERAIEHVTSFTPFGSITKL
EEEECCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEC
DRGERYKIRKVVVKKDKEIPLRMHHHRTVHFVVLKGTAKVKVGDKEEFVHENESFFVPKS
CCCCCEEEEEEEECCCCCCCEEEECCCEEEEEEEECCEEEEECCHHHHHCCCCCEECCCC
TPYKIINVGKIPLEMIEVQSGEYLGEDDVETLE
CCEEEEEECCCCEEEEEECCCCCCCCCCHHHCC
>Mature Secondary Structure
MKILILSGGKGTRLWPLSRENFPKQFIRLFSKHSLFQETVKRAKKLAKDEDIVVITGEKY
CEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCE
EWIIRSELEEIDANEVRVVVEPEGRNTAPAIALGVKYLIHSETPPSETVLVLPSDHLIKD
EEHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHEEECCCCCCCEEEECCCCHHHHH
TEKFVEAVKKGEKYAKEGYIVLFGEKPTYPETGYGYIRLNGKLEEGVYEIEKFEEKPDYE
HHHHHHHHHHCHHHHHCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHH
KAKEYVSDGKHFWNCGIFLFTLDRIVKDYTQLMPEIPFHEKWEDFIKDFKNFEEISFDYA
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHH
ILERTKKLAVVKMDAGWSDVGSWKAVYDNLPKDEKRNVLIGDVKAMDTECSLLLSQGKNL
HHHHCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCE
IACIGLEDFVVVGTEDATLIVKRDYSQKVKEIVKELEEENDERAIEHVTSFTPFGSITKL
EEEECCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEC
DRGERYKIRKVVVKKDKEIPLRMHHHRTVHFVVLKGTAKVKVGDKEEFVHENESFFVPKS
CCCCCEEEEEEEECCCCCCCEEEECCCEEEEEEEECCEEEEECCHHHHHCCCCCEECCCC
TPYKIINVGKIPLEMIEVQSGEYLGEDDVETLE
CCEEEEEECCCCEEEEEECCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]