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The map label for this gene is deoD [C]

Identifier: 15606022

GI number: 15606022

Start: 387432

End: 388265

Strand: Direct

Name: deoD [C]

Synonym: aq_568

Alternate gene names: 15606022

Gene position: 387432-388265 (Clockwise)

Preceding gene: 15606020

Following gene: 15606028

Centisome position: 24.97

GC content: 47.6

Gene sequence:

>834_bases
ATGCTCGGAATAATAGGCGGAAGCGGACTCTACAACCTCCCCGGCATAAAGGTAAAAGAAGAGGTTCAGGTAAAAACTCC
CTTCGGAGAGCCTTCCTCTCCCGTGGTAATAGCGGAGGTAGAAGGAAAAAAAGTAGCCTTTTTAGCGAGACACGGAAGGG
GGCATGAATACCCCCCTCACCTAGTCCCTTACAGGGCGAATTTATGGGCTTTGAGGGAAGTAGGTGTTAAGAGAGTTCTC
GGAATCAGTGCGGTCGGCGGTATAAACGAACTCTTGATGCCCGGAGATTTTGTGGTAATCCACGACTACCTTGACTTTAC
GAAGACCAGAAGGTCTACCTATTACGAAGGGAAGTTTTCCGTTAAGGTGGAGGGAGAAGACAAGGTGGCTAAGCTCTTGC
GGGAAGGGAAGGTGGTTCACGTGGACATGAGTGAGGCTTACTGTCCTGAAATGAGAAAAGTTCTTATACAAATCCTGAAG
GAGAAAAATTTCAGATTTCACCCGAAAGGTGTTTACGCCTGCACGGAGGGACCGCGGTTTGAAACTCCATCTGAGATAAA
GATGTTAAAACTCCTCGGTGCGGACGTTGTTGGAATGACAGGATACCCGGAGGTGGCACTTGCGAGAGAACTCACGATGT
GCTACGCGAGCCTTTGCGTGGTTGCAAACCCTGCTGCGGGAATAGCGGGATACAGACTGACCAGCAACGAGGTCATTCAA
TTGATGAAGAGGAAAGAAGAAGAAATAAAGGAAGTAGTGCTTAAATTCATAAAAGAACTTCCCGAAATTAGAAGTTGTGA
TTGTGAAAAATCTCTGGAGGGAGCTGAGGTATGA

Upstream 100 bases:

>100_bases
GCTCCAGGCGTCCGTTGTAAAGCTCTCCCTGTTTATCTCGTAAACCCTCTCCACATCCTCCCTTTCCATTTCCCTGACTT
TTAACATTAAGATTTATTTT

Downstream 100 bases:

>100_bases
ATATAGAACAAATTCTTCATAACGAGGCATTTAAGGAGTTCGGAACGGGAGCTTTGATAGGTTTTACGCTGGGCTACACT
TTCAAAAAGTTATTTAAGGT

Product: purine nucleoside phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MLGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPHLVPYRANLWALREVGVKRVL
GISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFSVKVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILK
EKNFRFHPKGVYACTEGPRFETPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQ
LMKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGAEV

Sequences:

>Translated_277_residues
MLGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPHLVPYRANLWALREVGVKRVL
GISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFSVKVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILK
EKNFRFHPKGVYACTEGPRFETPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQ
LMKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGAEV
>Mature_277_residues
MLGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPHLVPYRANLWALREVGVKRVL
GISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFSVKVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILK
EKNFRFHPKGVYACTEGPRFETPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQ
LMKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGAEV

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=274, Percent_Identity=34.6715328467153, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1788746, Length=119, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980569, Length=263, Percent_Identity=33.0798479087452, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323045, Length=237, Percent_Identity=35.0210970464135, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323238, Length=245, Percent_Identity=27.3469387755102, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130079, Length=284, Percent_Identity=32.7464788732394, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221459247, Length=260, Percent_Identity=31.9230769230769, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30812; Mature: 30812

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPH
CEEEECCCCCCCCCCCCEECEEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCC
LVPYRANLWALREVGVKRVLGISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHCCEEECCEEE
VKVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILKEKNFRFHPKGVYACTEGPRF
EEECCHHHHHHHHHCCCEEEEECHHHHCHHHHHHHHHHHHHCCCEECCCCEEEECCCCCC
ETPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQ
CCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHH
LMKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGAEV
HHHHHHHHHHHHHHHHHHHCHHHHCCCCHHCCCCCCC
>Mature Secondary Structure
MLGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPH
CEEEECCCCCCCCCCCCEECEEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCC
LVPYRANLWALREVGVKRVLGISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHCCEEECCEEE
VKVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILKEKNFRFHPKGVYACTEGPRF
EEECCHHHHHHHHHCCCEEEEECHHHHCHHHHHHHHHHHHHCCCEECCCCEEEECCCCCC
ETPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQ
CCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHH
LMKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGAEV
HHHHHHHHHHHHHHHHHHHCHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]