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The map label for this gene is hpt

Identifier: 15606004

GI number: 15606004

Start: 369242

End: 369778

Strand: Direct

Name: hpt

Synonym: aq_544

Alternate gene names: 15606004

Gene position: 369242-369778 (Clockwise)

Preceding gene: 15606003

Following gene: 15606006

Centisome position: 23.8

GC content: 43.2

Gene sequence:

>537_bases
ATGAAGGAGATAAGGGGAAAGAAGTTAAAACTTCTCTTGAAGGAAGAGGACATAAAGAGAAGGGTAAAGGAACTCGCTAA
AGAGATTGAGAGCTCTTATTCCTGGGAGGAGCCCATAGTCGTGGTCGGGCTCCTCAAGGGCGCTTTTATATTCTTGGCAG
ACCTAGTCAGGGCTTTTGACAGGTTCGTGTTCGTGGAGTTTATGCAAGTCTCAAGCTACGGTAAGGGAATGAAGAGTTCT
GGAACGATAAAGATAGTAAAGGATTTAGATATGGACATAGAAGGAAAGGAAGTTCTCCTCGTGGACGACATACTAGACAC
CGGACTCACTATGAAAGAAATTCACGACTACCTTCTGATGAAGAAGCCGAAAGTTTTAAAGACGTGCGTGTTTTTAGACA
AAAAGGAGAGGAGGAAGGTGGATTTTAACGCGGACTTTGTAGGTTTTGAAGTTCCAGATAAATTTTTAGTGGGATACGGA
TTGGATTGGGGAGAATACGGGAGAAACCTCCCCGAAGTTTACATGGTAGAAGATTGA

Upstream 100 bases:

>100_bases
AGAGAATGTCTCAAAGGGGAACTCGGAATAATCCCCGCGGTGAAGATAACACAACTCCTTCTTGCAAACGCTCTTAGACT
CAAGAAGTACGGAGCTTAAT

Downstream 100 bases:

>100_bases
AAAAAATCAGCCCGCGAGGGCAAGATGTCCCTCACTATATCTTCTTGAAGGGTCTTGAAGTCCTGCCTGATTTCCGAGAA
CTTTTCAAGTAAATCCAAGT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MKEIRGKKLKLLLKEEDIKRRVKELAKEIESSYSWEEPIVVVGLLKGAFIFLADLVRAFDRFVFVEFMQVSSYGKGMKSS
GTIKIVKDLDMDIEGKEVLLVDDILDTGLTMKEIHDYLLMKKPKVLKTCVFLDKKERRKVDFNADFVGFEVPDKFLVGYG
LDWGEYGRNLPEVYMVED

Sequences:

>Translated_178_residues
MKEIRGKKLKLLLKEEDIKRRVKELAKEIESSYSWEEPIVVVGLLKGAFIFLADLVRAFDRFVFVEFMQVSSYGKGMKSS
GTIKIVKDLDMDIEGKEVLLVDDILDTGLTMKEIHDYLLMKKPKVLKTCVFLDKKERRKVDFNADFVGFEVPDKFLVGYG
LDWGEYGRNLPEVYMVED
>Mature_178_residues
MKEIRGKKLKLLLKEEDIKRRVKELAKEIESSYSWEEPIVVVGLLKGAFIFLADLVRAFDRFVFVEFMQVSSYGKGMKSS
GTIKIVKDLDMDIEGKEVLLVDDILDTGLTMKEIHDYLLMKKPKVLKTCVFLDKKERRKVDFNADFVGFEVPDKFLVGYG
LDWGEYGRNLPEVYMVED

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=171, Percent_Identity=37.4269005847953, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI9910262, Length=178, Percent_Identity=35.3932584269663, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI87081689, Length=164, Percent_Identity=43.9024390243902, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17510817, Length=175, Percent_Identity=35.4285714285714, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_AQUAE (O66821)

Other databases:

- EMBL:   AE000657
- PIR:   A70349
- RefSeq:   NP_213381.1
- ProteinModelPortal:   O66821
- SMR:   O66821
- GeneID:   1193239
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_544
- NMPDR:   fig|224324.1.peg.396
- HOGENOM:   HBG536385
- OMA:   ESSREVR
- PhylomeDB:   O66821
- ProtClustDB:   CLSK2299424
- BioCyc:   AAEO224324:AQ_544-MONOMER
- BRENDA:   2.4.2.8
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20629; Mature: 20629

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIRGKKLKLLLKEEDIKRRVKELAKEIESSYSWEEPIVVVGLLKGAFIFLADLVRAFD
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
RFVFVEFMQVSSYGKGMKSSGTIKIVKDLDMDIEGKEVLLVDDILDTGLTMKEIHDYLLM
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECHHHCCCCHHHHHHHHHH
KKPKVLKTCVFLDKKERRKVDFNADFVGFEVPDKFLVGYGLDWGEYGRNLPEVYMVED
CCCHHHHHHHHHCCHHCCEECCCCCEEEEECCCHHEEECCCCHHHHCCCCCCEEEECC
>Mature Secondary Structure
MKEIRGKKLKLLLKEEDIKRRVKELAKEIESSYSWEEPIVVVGLLKGAFIFLADLVRAFD
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
RFVFVEFMQVSSYGKGMKSSGTIKIVKDLDMDIEGKEVLLVDDILDTGLTMKEIHDYLLM
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECHHHCCCCHHHHHHHHHH
KKPKVLKTCVFLDKKERRKVDFNADFVGFEVPDKFLVGYGLDWGEYGRNLPEVYMVED
CCCHHHHHHHHHCCHHCCEECCCCCEEEEECCCHHEEECCCCHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320