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The map label for this gene is mutY3 [H]

Identifier: 15605969

GI number: 15605969

Start: 333390

End: 334088

Strand: Direct

Name: mutY3 [H]

Synonym: aq_496

Alternate gene names: 15605969

Gene position: 333390-334088 (Clockwise)

Preceding gene: 15605968

Following gene: 15605979

Centisome position: 21.49

GC content: 42.06

Gene sequence:

>699_bases
ATGGCGAAACGTAAAGGCAAAGGGACACGTAGCGAAAGTAATAGAAACCTTGAAGAGCTTAGAAGAAAAGCAGTAGAAAT
AGTAAAGAGACTAGAAAAAGTTTACCTCAACCCGAGGCTCGAACTGGAGTACGAAAATGCCTTTCAGCTCCTCGTTATGG
CTATACTCGCAGCCCAGGAAAGTGACAAAGTCGTAAACAAGGTAAGTAAAGAGTTCTTCAAAAAGTACAAAACTCCTCAG
GATATAGCAAGGGCAAATTTAGAAGAACTGGAAGAGGACTTAAAACACATAAACTTCTACCGAAGAAAGGCAAAGCTTAT
TAAAGAGTGCTGTGAAAAATTAATAGAGCTCTACAAGGGAGAGGTTCCCAAAAGTGTGGGAGAACTAGTAAAACTGCCGG
GAGTAGGGAGAAAAACCGCAAACATGGTAATAGGTGGAGCTTACAACCTTCCTGCGATAATAGTTGACAGACACGTCCAC
AGAGTGGTTGAAAGGATAAGTCTGAGCAAACAAAAGAACCCTGACAAGATGGAGATGGAATTAAGCGAAATAGTCCCTCA
GGAGCTCTGGACAAAGTTTTCCCTTTTGCTCCTAAACCACGGAAAGACTATATGTAAAGCGAGAAATCCGGAGTGTGAAA
AGTGTCCGATACTTGACCTTTGTGAATACGGACAGAAGAACCTCAAAGGCAGGAAATGA

Upstream 100 bases:

>100_bases
TGTTCGGGGTTTACGGGGAAAAGAAGGCTTACGGCAAGGTAACTAAAGGGATTATACGTTCAACTTTTCTTATAGACGAA
GAGGGGAGGATAATAAAGGA

Downstream 100 bases:

>100_bases
AATCCTCTGCAAATTCTGGAATAAGGACTCTGTCATCGTAAGTCAAAACTTCCTTTTCTTTTTTCAATAGAGGTTCTGTT
TTTTCCCAGAGTATCTCCGT

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MAKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQESDKVVNKVSKEFFKKYKTPQ
DIARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKGEVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVH
RVVERISLSKQKNPDKMEMELSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK

Sequences:

>Translated_232_residues
MAKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQESDKVVNKVSKEFFKKYKTPQ
DIARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKGEVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVH
RVVERISLSKQKNPDKMEMELSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK
>Mature_231_residues
AKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQESDKVVNKVSKEFFKKYKTPQD
IARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKGEVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVHR
VVERISLSKQKNPDKMEMELSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=181, Percent_Identity=32.5966850828729, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI115298648, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI6912520, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI115298654, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI115298652, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI115298650, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI190358497, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1787920, Length=206, Percent_Identity=37.8640776699029, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789331, Length=180, Percent_Identity=26.1111111111111, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17554540, Length=177, Percent_Identity=31.638418079096, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319304, Length=175, Percent_Identity=29.7142857142857, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324530, Length=187, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550361, Length=188, Percent_Identity=31.9148936170213, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 26847; Mature: 26716

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCH
SDKVVNKVSKEFFKKYKTPQDIARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKG
HHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVHRVVERISLSKQKNPDKMEME
CCCHHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHCCHHHCCCCC
>Mature Secondary Structure 
AKRKGKGTRSESNRNLEELRRKAVEIVKRLEKVYLNPRLELEYENAFQLLVMAILAAQE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCH
SDKVVNKVSKEFFKKYKTPQDIARANLEELEEDLKHINFYRRKAKLIKECCEKLIELYKG
HHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EVPKSVGELVKLPGVGRKTANMVIGGAYNLPAIIVDRHVHRVVERISLSKQKNPDKMEME
CCCHHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSEIVPQELWTKFSLLLLNHGKTICKARNPECEKCPILDLCEYGQKNLKGRK
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]