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The map label for this gene is hemC [H]

Identifier: 15605804

GI number: 15605804

Start: 168918

End: 169889

Strand: Direct

Name: hemC [H]

Synonym: aq_263

Alternate gene names: 15605804

Gene position: 168918-169889 (Clockwise)

Preceding gene: 15605799

Following gene: 15605805

Centisome position: 10.89

GC content: 44.44

Gene sequence:

>972_bases
GTGTACCCCGTTTGGGGTACCGAGGGTTCGAATCCCTCCCCTTCCGCCATTCCCGCTATGAAAATCAGGATTGGAACTAG
GAAGAGTAAACTCGCCCTGTGGCAGGCGAATTACGTAAAAGATTTCTTAGAAAAACACTGGGGTGTTGAAGTAGAACTCG
TAAAGATAACAACAACGGGAGACAAAATTACCGATGTTCCCCTTGCAAAAATAGGAGGAAAAGGACTTTTTGTTAAGGAG
ATAGAAAAAGCGTTGCTCGAGGGTAGTATAGACCTTGCGGTCCACTCCTTGAAGGACGTCCCTATGGTTATACCCAAAGG
TCTGAAACTCGGAGCTATAACAAAGAGGGAAAACCCCTACGACGTTTTAATATCGCGAAGCGGAAAGAAACTTTATGAAC
TTCCCTCGGGTTCTGTTATAGGTACTTCTTCTCTAAGGAGACAGGTTCAGATAAAGAAAAGGAGAAGGGATTTAAAGGTA
GAAGTCCTAAGGGGAAACGTGGACACTAGAATGAGGAAACTGAAGGAAGGACTCTACGACGCAGTAATCCTAGCATACGC
AGGTGTAAAGAGGATGGGTTACGAAAGTGAGATAACGGAAGTGCTTGAAGACTTCATCCCTGCGGTAGGACAGGGCTCTC
TCGCAATAGAAATCAGAGAAGGAGATAAAAGGATAGAGGAGTTAATAAAACCTCTAAACAACGAGGAGAGTTTTCTCTGC
GCAATTGCGGAAAGGACGTTCTTAAGGAGGCTTGAGGGAGGATGTCAGGTTCCCGTGGGAGCCTTTGCTAAGATAGAAAA
CGGAACTCTTAAGATGAAAGCCTTTATATCTGACATTGAGGCTGAAAGGTATATAGAAGGGTATAGAGAAGGAAATCCCG
AGGAGGCAGAAAAACTGGGACTTTCACTTGCAGAAGAACTCTTGAAAAAAGGCGGGGAGGAAATATTGAAGGAAATATAC
TCTTCCCAATGA

Upstream 100 bases:

>100_bases
AAGGTATATGAAGAGTATGAAAAACGAAACAAAGGAATTATAATTATTTATCTGGTAGGAAGGGTGGCCGAGCGGTCGAA
GGCGCGGCGCTGGAAACGCC

Downstream 100 bases:

>100_bases
GGTTTTTAGGCTTTGGAATTTTCTCTCCCGAAGAGAATATGAAAATAGACGAAGAATTACAGATTAAACTTGAAAATGGA
GAAATTGAACCCTGTTTTCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MYPVWGTEGSNPSPSAIPAMKIRIGTRKSKLALWQANYVKDFLEKHWGVEVELVKITTTGDKITDVPLAKIGGKGLFVKE
IEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPYDVLISRSGKKLYELPSGSVIGTSSLRRQVQIKKRRRDLKV
EVLRGNVDTRMRKLKEGLYDAVILAYAGVKRMGYESEITEVLEDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLC
AIAERTFLRRLEGGCQVPVGAFAKIENGTLKMKAFISDIEAERYIEGYREGNPEEAEKLGLSLAEELLKKGGEEILKEIY
SSQ

Sequences:

>Translated_323_residues
MYPVWGTEGSNPSPSAIPAMKIRIGTRKSKLALWQANYVKDFLEKHWGVEVELVKITTTGDKITDVPLAKIGGKGLFVKE
IEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPYDVLISRSGKKLYELPSGSVIGTSSLRRQVQIKKRRRDLKV
EVLRGNVDTRMRKLKEGLYDAVILAYAGVKRMGYESEITEVLEDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLC
AIAERTFLRRLEGGCQVPVGAFAKIENGTLKMKAFISDIEAERYIEGYREGNPEEAEKLGLSLAEELLKKGGEEILKEIY
SSQ
>Mature_323_residues
MYPVWGTEGSNPSPSAIPAMKIRIGTRKSKLALWQANYVKDFLEKHWGVEVELVKITTTGDKITDVPLAKIGGKGLFVKE
IEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPYDVLISRSGKKLYELPSGSVIGTSSLRRQVQIKKRRRDLKV
EVLRGNVDTRMRKLKEGLYDAVILAYAGVKRMGYESEITEVLEDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLC
AIAERTFLRRLEGGCQVPVGAFAKIENGTLKMKAFISDIEAERYIEGYREGNPEEAEKLGLSLAEELLKKGGEEILKEIY
SSQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=336, Percent_Identity=41.9642857142857, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=41.9939577039275, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=53.1353135313531, Blast_Score=316, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=40.1898734177215, Blast_Score=215, Evalue=6e-57,
Organism=Drosophila melanogaster, GI20130425, Length=253, Percent_Identity=42.2924901185771, Blast_Score=197, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35974; Mature: 35974

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPVWGTEGSNPSPSAIPAMKIRIGTRKSKLALWQANYVKDFLEKHWGVEVELVKITTTG
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
DKITDVPLAKIGGKGLFVKEIEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPY
CCCCCCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEECCCCCEECEEECCCCCC
DVLISRSGKKLYELPSGSVIGTSSLRRQVQIKKRRRDLKVEVLRGNVDTRMRKLKEGLYD
EEEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
AVILAYAGVKRMGYESEITEVLEDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLC
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHH
AIAERTFLRRLEGGCQVPVGAFAKIENGTLKMKAFISDIEAERYIEGYREGNPEEAEKLG
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSLAEELLKKGGEEILKEIYSSQ
HHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MYPVWGTEGSNPSPSAIPAMKIRIGTRKSKLALWQANYVKDFLEKHWGVEVELVKITTTG
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
DKITDVPLAKIGGKGLFVKEIEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPY
CCCCCCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEECCCCCEECEEECCCCCC
DVLISRSGKKLYELPSGSVIGTSSLRRQVQIKKRRRDLKVEVLRGNVDTRMRKLKEGLYD
EEEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
AVILAYAGVKRMGYESEITEVLEDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLC
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHH
AIAERTFLRRLEGGCQVPVGAFAKIENGTLKMKAFISDIEAERYIEGYREGNPEEAEKLG
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSLAEELLKKGGEEILKEIYSSQ
HHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]