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The map label for this gene is cobA [H]

Identifier: 15605767

GI number: 15605767

Start: 127845

End: 128579

Strand: Direct

Name: cobA [H]

Synonym: aq_207

Alternate gene names: 15605767

Gene position: 127845-128579 (Clockwise)

Preceding gene: 15605766

Following gene: 15605768

Centisome position: 8.24

GC content: 45.99

Gene sequence:

>735_bases
ATGGGAAAGGTTTACCTCATAGGAGCCGGTCCTGGAGACCCTGAGCTTCTGACACTTAAAGCTTATCGTATTCTCAGGAA
AGCTGACGTAGTTCTATACGATGCCTTGGTAAACAGGGAAATACTTCACTTTGCCAGACAAGACAGCCTTAAGATATACG
TGGGCAAGAGAGACGGAAAACACTCCTTGCCTCAGGAGGAGATAAATGAACTTCTTCACAGGTTTGCACTTAGCTACAAA
ATTGTAGTTAGACTTAAAGGCGGTGACCCTTTTGTGTTCGGAAGGGGCGGAGAAGAACTCCTTTACCTAAAAAGCAGGGG
TGTGGAAGTGGAAATAGTACCGGGTATAACTTCGGCGATTTCTGCACCCTCCTCCGCTTTCATTCCCGTAACACATAGGG
GAATAGCCTCGTCGTTTGCGGTTGTTACAGGCCACCCCAACAGAGAAATAAAATGGGAGGATTTAGTGAATATAGATACA
CTCGTTGTTCTTATGGGTGTTAAGAACAGAGAAAAGATAGCGAGAGAACTTATAGGAGCAGGACGAAACCCGGACGAACC
CGTTGCCTTTATAGAGAAGGCTACAACTCCGGAGCAGAGGGAAGTTTTCAGCACATTGAAAGAAGTTGCTCAAAACCCGC
CGGAGGTAAACCCGCCCGCTGTAATGGTTGTAGGAAAGGTCGTAGAAATAGGAGCAAAAGTCCTATGTGAACGTATAATC
GGCGTTACACTTTAA

Upstream 100 bases:

>100_bases
AGTGGATAAACTCAAGGTGGTTCTTACAAGTCTTTTACAGGAAGGGGAATGTAAGCTACTGAAACCCGAGAGTATAAGCA
AGTAAAGGAGGAAGTGGAGT

Downstream 100 bases:

>100_bases
AGGAATGGACATTTTAGAAAGAACTTTCAAAAAATTAACGAGACTTAAGGATAACCTTCAGGACCTTTCTCAGGAAGAAG
CCTATGAAGTATTTAGGGCT

Product: uroporphyrin-III c-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MGKVYLIGAGPGDPELLTLKAYRILRKADVVLYDALVNREILHFARQDSLKIYVGKRDGKHSLPQEEINELLHRFALSYK
IVVRLKGGDPFVFGRGGEELLYLKSRGVEVEIVPGITSAISAPSSAFIPVTHRGIASSFAVVTGHPNREIKWEDLVNIDT
LVVLMGVKNREKIARELIGAGRNPDEPVAFIEKATTPEQREVFSTLKEVAQNPPEVNPPAVMVVGKVVEIGAKVLCERII
GVTL

Sequences:

>Translated_244_residues
MGKVYLIGAGPGDPELLTLKAYRILRKADVVLYDALVNREILHFARQDSLKIYVGKRDGKHSLPQEEINELLHRFALSYK
IVVRLKGGDPFVFGRGGEELLYLKSRGVEVEIVPGITSAISAPSSAFIPVTHRGIASSFAVVTGHPNREIKWEDLVNIDT
LVVLMGVKNREKIARELIGAGRNPDEPVAFIEKATTPEQREVFSTLKEVAQNPPEVNPPAVMVVGKVVEIGAKVLCERII
GVTL
>Mature_243_residues
GKVYLIGAGPGDPELLTLKAYRILRKADVVLYDALVNREILHFARQDSLKIYVGKRDGKHSLPQEEINELLHRFALSYKI
VVRLKGGDPFVFGRGGEELLYLKSRGVEVEIVPGITSAISAPSSAFIPVTHRGIASSFAVVTGHPNREIKWEDLVNIDTL
VVLMGVKNREKIARELIGAGRNPDEPVAFIEKATTPEQREVFSTLKEVAQNPPEVNPPAVMVVGKVVEIGAKVLCERIIG
VTL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=236, Percent_Identity=44.4915254237288, Blast_Score=200, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=34.3347639484979, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 26809; Mature: 26677

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLIGAGPGDPELLTLKAYRILRKADVVLYDALVNREILHFARQDSLKIYVGKRDGK
CCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
HSLPQEEINELLHRFALSYKIVVRLKGGDPFVFGRGGEELLYLKSRGVEVEIVPGITSAI
CCCCHHHHHHHHHHHHCEEEEEEEEECCCEEEECCCCCEEEEEECCCCEEEEECCCHHHH
SAPSSAFIPVTHRGIASSFAVVTGHPNREIKWEDLVNIDTLVVLMGVKNREKIARELIGA
CCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHCCHHEEEEEECCCCHHHHHHHHHHC
GRNPDEPVAFIEKATTPEQREVFSTLKEVAQNPPEVNPPAVMVVGKVVEIGAKVLCERII
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
GVTL
HCCC
>Mature Secondary Structure 
GKVYLIGAGPGDPELLTLKAYRILRKADVVLYDALVNREILHFARQDSLKIYVGKRDGK
CEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
HSLPQEEINELLHRFALSYKIVVRLKGGDPFVFGRGGEELLYLKSRGVEVEIVPGITSAI
CCCCHHHHHHHHHHHHCEEEEEEEEECCCEEEECCCCCEEEEEECCCCEEEEECCCHHHH
SAPSSAFIPVTHRGIASSFAVVTGHPNREIKWEDLVNIDTLVVLMGVKNREKIARELIGA
CCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHCCHHEEEEEECCCCHHHHHHHHHHC
GRNPDEPVAFIEKATTPEQREVFSTLKEVAQNPPEVNPPAVMVVGKVVEIGAKVLCERII
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
GVTL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]