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The map label for this gene is hly3 [C]

Identifier: 15605690

GI number: 15605690

Start: 62770

End: 64020

Strand: Direct

Name: hly3 [C]

Synonym: aq_101

Alternate gene names: 15605690

Gene position: 62770-64020 (Clockwise)

Preceding gene: 15605689

Following gene: 15605693

Centisome position: 4.05

GC content: 43.49

Gene sequence:

>1251_bases
ATGGAGCTGATAGGTTTTCTAATAGGAGTTTTCTTCTTCATAATCCTTGAGGGATTTTTTGCAGGGTCAGAGATAGCTCT
AGTGAACGCTGACAAAGGCTTTTTAAAGGCAGTTTACAAGAAGAAAAAGTACTCATTTCTGAAGCACTTCCTTGACAGTC
CTGAGGAGTACATCACCCTCACTATGCTCGGATACACCGTTTCCATAGTTTTCGCATCTGCCCTTTACACGCTATTCCTA
ATGAACCTTTCAAAGTACGTTCCTGAGATAAAGGGAAAAGAAGTCCTCCTTGCGGAAACCTTGGTGATATTCACAATAAT
CCTCGGTGAGATAATACCTAAAAGCCTATTTCAGCATTACGCGGATAAGGTTGTAATACCGAGCCTCTATATCCTCGATA
AACTCAGAATAGTTTTAAAGCCCTTTTTGGTTCTTGCAAAGGCGGTAAGCAGGTTCATATCGAGCAGGTTCGCAAAAGGC
GAAAGTAAGGTAAGGAGAGAAGACATAATTAAACTACTCAGGGAGAAAAAGAGCTTCTCCGAGTCCTTAGGCTACGTAAT
TTCCAACATACTGTCTTTTAAGGAAAGAAGGATAGGGGAGATTGTAAGACCGCTTTACGAAGTAGTTATGATTCCCGATA
CCGCCACAGTTCTTCAGGCTATTGAGCAAATAAAGAAGAGCGGATACGCCAGGATACCAGTTTACAGAAAGCGGGTTGAC
GACATAATCGGATACGTGAGCGCTTACGATCTTATAGACAAACCCCTTGACGAACCCATTAAATCCTTTATAAGGAGAAT
CCTTATCTTCAGTGAATTCACACCACTTCCTAAGGTTCTGGAGGTTTTCAAGGAGAAGAAGGAACACATAGCCCTTGTGG
TAGACGAGAGAGGTGTAATCCTCGGCATAGTTACCCTTGAAGACATTTTCAGGGAAATACTGGGAGACTTCATATCGGAA
AAGGGAGAAGAGCCACTGGTGAGGGAAGTGAGTAAGGACACATGGGTAGCGGACGGAAAGGTTGAAATAAACGAGCTCAG
GAGAATTACAGGAATAAATATCCCGGACGGTCCCTACAACACACTTTCAGGCTTTATAGCCTACCAGCTCGGAAGGATTC
CCAAAAAGGGAGACGTAGTTTCCTACGACGGATACAACTTTAAGGTAGTTGACGGAGACACGAGAAGGGTGAGGAAGGTT
TTAATAGAGAGGAAGGTTAAAAAGAAGGCTTTATCGGGAGCGTCCGCCTGA

Upstream 100 bases:

>100_bases
ACCAGGGAAAAGTTGTTAAGGAACTCCTTGAAAAGAAATGTTTTAAAGTTAATATTTTTAAGGACTACGCTGGATTTGAC
AGGGTGGTGATAGCACAGAG

Downstream 100 bases:

>100_bases
CCTCTTCTATATAATCTTTGTCGTAATCTGCGGCAAGTAAGGTATCCCCTTTCTCGGAAAAGGCAAGAACTTCTCCCCAA
GGTGAGTAAATTCCCGAATG

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MELIGFLIGVFFFIILEGFFAGSEIALVNADKGFLKAVYKKKKYSFLKHFLDSPEEYITLTMLGYTVSIVFASALYTLFL
MNLSKYVPEIKGKEVLLAETLVIFTIILGEIIPKSLFQHYADKVVIPSLYILDKLRIVLKPFLVLAKAVSRFISSRFAKG
ESKVRREDIIKLLREKKSFSESLGYVISNILSFKERRIGEIVRPLYEVVMIPDTATVLQAIEQIKKSGYARIPVYRKRVD
DIIGYVSAYDLIDKPLDEPIKSFIRRILIFSEFTPLPKVLEVFKEKKEHIALVVDERGVILGIVTLEDIFREILGDFISE
KGEEPLVREVSKDTWVADGKVEINELRRITGINIPDGPYNTLSGFIAYQLGRIPKKGDVVSYDGYNFKVVDGDTRRVRKV
LIERKVKKKALSGASA

Sequences:

>Translated_416_residues
MELIGFLIGVFFFIILEGFFAGSEIALVNADKGFLKAVYKKKKYSFLKHFLDSPEEYITLTMLGYTVSIVFASALYTLFL
MNLSKYVPEIKGKEVLLAETLVIFTIILGEIIPKSLFQHYADKVVIPSLYILDKLRIVLKPFLVLAKAVSRFISSRFAKG
ESKVRREDIIKLLREKKSFSESLGYVISNILSFKERRIGEIVRPLYEVVMIPDTATVLQAIEQIKKSGYARIPVYRKRVD
DIIGYVSAYDLIDKPLDEPIKSFIRRILIFSEFTPLPKVLEVFKEKKEHIALVVDERGVILGIVTLEDIFREILGDFISE
KGEEPLVREVSKDTWVADGKVEINELRRITGINIPDGPYNTLSGFIAYQLGRIPKKGDVVSYDGYNFKVVDGDTRRVRKV
LIERKVKKKALSGASA
>Mature_416_residues
MELIGFLIGVFFFIILEGFFAGSEIALVNADKGFLKAVYKKKKYSFLKHFLDSPEEYITLTMLGYTVSIVFASALYTLFL
MNLSKYVPEIKGKEVLLAETLVIFTIILGEIIPKSLFQHYADKVVIPSLYILDKLRIVLKPFLVLAKAVSRFISSRFAKG
ESKVRREDIIKLLREKKSFSESLGYVISNILSFKERRIGEIVRPLYEVVMIPDTATVLQAIEQIKKSGYARIPVYRKRVD
DIIGYVSAYDLIDKPLDEPIKSFIRRILIFSEFTPLPKVLEVFKEKKEHIALVVDERGVILGIVTLEDIFREILGDFISE
KGEEPLVREVSKDTWVADGKVEINELRRITGINIPDGPYNTLSGFIAYQLGRIPKKGDVVSYDGYNFKVVDGDTRRVRKV
LIERKVKKKALSGASA

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=379, Percent_Identity=25.8575197889182, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI40068055, Length=341, Percent_Identity=24.9266862170088, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40068053, Length=341, Percent_Identity=24.9266862170088, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI145693175, Length=401, Percent_Identity=25.1870324189526, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790664, Length=448, Percent_Identity=25.8928571428571, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786879, Length=259, Percent_Identity=26.2548262548263, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082033, Length=265, Percent_Identity=26.7924528301887, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788119, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539402, Length=257, Percent_Identity=27.2373540856031, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324512, Length=340, Percent_Identity=23.8235294117647, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 47342; Mature: 47342

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIGFLIGVFFFIILEGFFAGSEIALVNADKGFLKAVYKKKKYSFLKHFLDSPEEYITL
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHEEH
TMLGYTVSIVFASALYTLFLMNLSKYVPEIKGKEVLLAETLVIFTIILGEIIPKSLFQHY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADKVVIPSLYILDKLRIVLKPFLVLAKAVSRFISSRFAKGESKVRREDIIKLLREKKSFS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ESLGYVISNILSFKERRIGEIVRPLYEVVMIPDTATVLQAIEQIKKSGYARIPVYRKRVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
DIIGYVSAYDLIDKPLDEPIKSFIRRILIFSEFTPLPKVLEVFKEKKEHIALVVDERGVI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCE
LGIVTLEDIFREILGDFISEKGEEPLVREVSKDTWVADGKVEINELRRITGINIPDGPYN
EEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCEEHHHHHHHHCCCCCCCCHH
TLSGFIAYQLGRIPKKGDVVSYDGYNFKVVDGDTRRVRKVLIERKVKKKALSGASA
HHHHHHHHHHCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELIGFLIGVFFFIILEGFFAGSEIALVNADKGFLKAVYKKKKYSFLKHFLDSPEEYITL
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHEEH
TMLGYTVSIVFASALYTLFLMNLSKYVPEIKGKEVLLAETLVIFTIILGEIIPKSLFQHY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADKVVIPSLYILDKLRIVLKPFLVLAKAVSRFISSRFAKGESKVRREDIIKLLREKKSFS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ESLGYVISNILSFKERRIGEIVRPLYEVVMIPDTATVLQAIEQIKKSGYARIPVYRKRVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
DIIGYVSAYDLIDKPLDEPIKSFIRRILIFSEFTPLPKVLEVFKEKKEHIALVVDERGVI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCE
LGIVTLEDIFREILGDFISEKGEEPLVREVSKDTWVADGKVEINELRRITGINIPDGPYN
EEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCEEHHHHHHHHCCCCCCCCHH
TLSGFIAYQLGRIPKKGDVVSYDGYNFKVVDGDTRRVRKVLIERKVKKKALSGASA
HHHHHHHHHHCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]